Results 1 to 10 of about 155,269 (289)

Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis

BMC Pharmacology and Toxicology, 2022
Background Linezolid causes hematological toxicity, mostly thrombocytopenia, which leads to treatment discontinuation and failure. Recent studies revealed that during linezolid therapy, the incidence of treatment-related hematological toxicity is ...
Xiaoxi Liu, Mari Aoki, Sumika Osa, Chihiro Ito, Reika Saiki, Tomoya Nagai, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto   +8 more
doaj   +1 more source

EEG and Sleep Effects of Tramadol Suggest Potential Antidepressant Effects with Different Mechanisms of Action

Pharmaceuticals, 2021
Tramadol is a widely used, centrally acting, opioid analgesic compound, with additional inhibitory effects on the synaptic reuptake of serotonin and noradrenaline, as well as on the 5-HT2 and NMDA receptors.
Szabolcs Koncz, Noémi Papp, Noémi Menczelesz, Dóra Pothorszki, György Bagdy   +4 more
doaj   +1 more source

The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review

Thrombosis Journal, 2023
The assessment of hemostasis is necessary to make suitable decisions on the management of patients with thrombotic disorders. In some clinical situations, for example, during thrombophilia screening, the presence of anticoagulants in sample makes ...
Aleksandra Frackiewicz, Bartlomiej Kalaska, Joanna Miklosz, Andrzej Mogielnicki   +3 more
doaj   +1 more source

A combination of 5/6‐nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease

FASEB BioAdvances, 2023
Chronic kidney disease (CKD) involves progressive renal fibrosis, which gradually reduces kidney function and often causes various complications in extrarenal tissues. Therefore, we investigated fibrogenesis in extrarenal tissues (heart, liver, and lungs)
Kyoka Homma, Yuki Enoki, Sato Uchida, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
doaj   +1 more source

Polysaccharide from Atractylodes macrocephala Koidz. ameliorates DSS-induced colitis in mice by regulating the Th17/Treg cell balance

Frontiers in Immunology, 2022
Atractylodes macrocephala Koidz. is one of the most frequently used traditional Chinese medicines for the treatment of ulcerative colitis (UC). The beneficial effect of polysaccharide from Atractylodes macrocephala Koidz.
Mengjiao Yang, Qianwen Zhang, Reham Taha, Mohammed Ismail Abdelmotalab, Qing Wen, Yuzhu Yuan, Yongrui Zhao, Qingyu Li, Chunyu Liao, Xin Huang, Zhenzhou Jiang, Chenghan Chu, Chunhua Jiao, Lixin Sun   +13 more
doaj   +1 more source

Additive effect of 5-HT2C and CB1 receptor blockade on the regulation of sleep–wake cycle

BMC Neuroscience, 2019
Background Previous data show that serotonin 2C (5-HT2C) and cannabinoid 1 (CB1) receptors have a role in the modulation of sleep–wake cycle. Namely, antagonists on these receptors promoted wakefulness and inhibited rapid eye movement sleep (REMS) in ...
Emese Bogáthy, Noémi Papp, Laszló Tóthfalusi, Szilvia Vas, György Bagdy   +4 more
doaj   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children [PDF]

, 2015
The study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillintazobactam in children hospitalized in an intensive care unit.
Buenger, Lauren E., Chung, Eun Kyoung, Crumby, Ashley S., Dees, Jennifer, Healy, Daniel P., Kays, Michael B., Knoderer, Chad A., Nichols, Kristen R.   +7 more
core   +2 more sources

Antibacterial Drug Development: A New Approach Is Needed for the Field to Survive and Thrive

Antibiotics, 2020
It is often said that the marketplace for new antibiotics is broken. This notion is supported by the observation that many recently-approved antibiotics to treat drug-resistant bacteria have failed commercially in a spectacular fashion.
M. Courtney Safir, Sujata M. Bhavnani, Christine M. Slover, Paul G. Ambrose, Christopher M. Rubino   +4 more
doaj   +1 more source

Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]

, 2019
Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller, Altamirano, Arechavala, Bicanic, Bicanic, Boeva, Chang, Chen, Dannaoui, DePristo, Drusano, Harrison, Li, Longley, Loyse, Martin, Mayanja-Kizza, McKenna, Molloy, Mondon, Neely, Nixon, Nussbaum, Saag, Sionov, Sionov, Stone, Stott, Stott, Sudan, Wiederhold, Witt   +31 more
core   +1 more source

Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats

BMC Genomics, 2018
Background 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) is a widely used entactogenic drug known to impair cognitive functions on the long-run. Both hippocampal and frontal cortical regions have well established roles in behavior, memory formation
Peter Petschner, Viola Tamasi, Csaba Adori, Eszter Kirilly, Romeo D. Ando, Laszlo Tothfalusi, Gyorgy Bagdy   +6 more
doaj   +1 more source