Results 21 to 30 of about 77,040 (258)
Evaluation of dosing strategy for pembrolizumab for oncology indications
Journal for ImmunoTherapy of Cancer, 2017 Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
Tomoko Freshwater +6 more
doaj +1 more source
PHARMACOKINETICS AND PHARMACODYNAMICS
British Journal of Anaesthesia, 1979 Many physiological systems appear to present data that is random or without order. The origins of this disorder are often attributed to variability introduced by the multifactorial determinants of the system. This classical view of physiological randomness has also been widely discussed in quantitative pharmacological systems. However, since the early
openaire +2 more sources
Pharmacodynamics of Memantine: An Update [PDF]
Current Neuropharmacology, 2008 Memantine received marketing authorization from the European Agency for the Evaluation of Medicinal Products (EMEA) for the treatment of moderately severe to severe Alzheimer s disease (AD) in Europe on 17(th) May 2002 and shortly thereafter was also approved by the FDA for use in the same indication in the USA.
Rammes, G., Danysz, W., Parsons, C.
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Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Targeting of the apelin–apelin receptor (Apj) system may serve as a useful therapeutic intervention for the management of chronic kidney disease (CKD)‐induced skeletal muscle atrophy.
Yuki Enoki +8 more
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The Language of Pharmacodynamics [PDF]
Clinical Cancer Research, 2014 The Oxford English Dictionary defines language as “the method of human communication, either spoken or written, consisting of the use of words in a structured and conventional way.” This CCR Focus section describes various ways in which anticancer agent pharmacodynamics (PD) is being studied,
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Advances in Drug and Alcohol Research, 2023 Nicotine is the primary psychoactive component responsible for maintaining tobacco dependence in humans. Chronic pain is often a consequence of tobacco-related pathologies, and the development of a dual therapeutic that could treat chronic pain and ...
Kevin Luque-Sanchez +8 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko +19 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Secretory phospholipase A2 (sPLA2) is an inflammatory mediator linked to acute chest syndrome (ACS) in sickle cell disease (SCD), a serious complication that can develop during an acute vaso‐occlusive pain episode (VOE). Plasma sPLA2 levels have been proposed as a potential biomarker for predicting ACS onset.
Rawan Korman +10 more
wiley +1 more source
Bridging the blood-brain barrier: strategies to improve delivery of biologics to tumors in the brain
Fluids and Barriers of the CNSThe unique anatomical and physiological features of the blood-brain barrier (BBB), while essential for maintenance of normal brain health, present significant challenges in development of effective therapies for neurological disorders from a drug ...
Gautham Gampa +5 more
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European Psychiatry, 2023 Introduction Depressive disorders are known heterogeneous both in their clinical manifestations and etiopathophysiology. Affective temperaments have a strong biological background and heritability, manifest at early age and remain stable throughout the ...
D. Győrik +7 more
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