Results 21 to 30 of about 93,887 (308)

Pharmacokinetics, Pharmacodynamics and Drug–Drug Interactions of New Anti-Migraine Drugs—Lasmiditan, Gepants, and Calcitonin-Gene-Related Peptide (CGRP) Receptor Monoclonal Antibodies

, 2020
In the last few years, there have been significant advances in migraine management and prevention. Lasmiditan, ubrogepant, rimegepant and monoclonal antibodies (erenumab, fremanezumab, galcanezumab, and eptinezumab) are new drugs that were launched on ...
Danuta Szkutnik-Fiedler
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Evaluation of dosing strategy for pembrolizumab for oncology indications

Journal for ImmunoTherapy of Cancer, 2017
Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
Tomoko Freshwater, Anna Kondic, Malidi Ahamadi, Claire H. Li, Rik de Greef, Dinesh de Alwis, Julie A. Stone   +6 more
doaj   +1 more source

Evaluation of novel epibatidine analogs in the rat nicotine drug discrimination assay and in the rat chronic constriction injury neuropathic pain model

Advances in Drug and Alcohol Research, 2023
Nicotine is the primary psychoactive component responsible for maintaining tobacco dependence in humans. Chronic pain is often a consequence of tobacco-related pathologies, and the development of a dual therapeutic that could treat chronic pain and ...
Kevin Luque-Sanchez, Jasmine Felix, Joshua Bilbrey, Luis Restrepo, Morgan Reeves, Lance R. McMahon, Lance R. McMahon, Jenny L. Wilkerson, Jenny L. Wilkerson   +8 more
doaj   +1 more source

Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model

Clinical and Translational Science, 2020
In the development of new drugs, the prediction of metabolite‐to‐parent plasma exposure ratio in humans prior to administration in a clinical study has emerged as an important need.
Ernesto Callegari, Manthena V.S. Varma, R. Scott Obach   +2 more
doaj   +1 more source

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

Journal of Hematology & Oncology, 2020
Background Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins.
Yonghan He, Raphael Koch, Vivekananda Budamagunta, Peiyi Zhang, Xuan Zhang, Sajid Khan, Dinesh Thummuri, Yuma T. Ortiz, Xin Zhang, Dongwen Lv, Janet S. Wiegand, Wen Li, Adam C. Palmer, Guangrong Zheng, David M. Weinstock, Daohong Zhou   +15 more
doaj   +1 more source

The G protein‐coupled receptor ligand apelin‐13 ameliorates skeletal muscle atrophy induced by chronic kidney disease

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Targeting of the apelin–apelin receptor (Apj) system may serve as a useful therapeutic intervention for the management of chronic kidney disease (CKD)‐induced skeletal muscle atrophy.
Yuki Enoki, Tomoya Nagai, Yuna Hamamura, Sumika Osa, Hideaki Nakamura, Kazuaki Taguchi, Hiroshi Watanabe, Toru Maruyama, Kazuaki Matsumoto   +8 more
doaj   +1 more source

Affective temperament polygenic risk scores predict depression: investigating the role of environmental factors

European Psychiatry, 2023
Introduction Depressive disorders are known heterogeneous both in their clinical manifestations and etiopathophysiology. Affective temperaments have a strong biological background and heritability, manifest at early age and remain stable throughout the ...
D. Győrik, D. Torok, B. Erdelyi-Hamza, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz, X. Gonda   +7 more
doaj   +1 more source

The Language of Pharmacodynamics [PDF]

Clinical Cancer Research, 2014
The Oxford English Dictionary defines language as “the method of human communication, either spoken or written, consisting of the use of words in a structured and conventional way.” This CCR Focus section describes various ways in which anticancer agent pharmacodynamics (PD) is being studied,
openaire   +2 more sources

PHARMACOKINETICS AND PHARMACODYNAMICS

British Journal of Anaesthesia, 1979
Many physiological systems appear to present data that is random or without order. The origins of this disorder are often attributed to variability introduced by the multifactorial determinants of the ­system. This classical view of physiological randomness has also been widely discussed in quantitative pharmacological systems. However, since the early
openaire   +2 more sources

Impact of aminophylline on the pharmacodynamics of propofol in beagle dogs

, 2018
Aminophylline; Interaction; Pharmacodynamics; Pharmacokinetics ...
이은경
core   +1 more source