Results 31 to 40 of about 101,624 (260)

Larks under pressure: The genetic background of the morning chronotype may contribute to depression in interaction with stress

European Psychiatry
Introduction Depression is a highly prevalent, multifactorial, complex disorder, its etiology is assumed to involve both genetic and environmental factors.
M. Csikos, S. Krause, Z. Gal, G. Bagdy, G. Juhasz, X. Gonda, D. Torok   +6 more
doaj   +1 more source

Affective temperament polygenic risk scores predict depression: investigating the role of environmental factors

European Psychiatry, 2023
Introduction Depressive disorders are known heterogeneous both in their clinical manifestations and etiopathophysiology. Affective temperaments have a strong biological background and heritability, manifest at early age and remain stable throughout the ...
D. Győrik, D. Torok, B. Erdelyi-Hamza, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz, X. Gonda   +7 more
doaj   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio
d‐Amino acid oxidase (DAO) inhibitors are novel candidate therapeutic agents for neurodegenerative diseases. In this study, a novel inhibition assay using WST‐8 as a detection reagent was developed and its effectiveness for evaluating redox‐based enzyme ...
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
doaj   +2 more sources

Physiologically based pharmacokinetic/pharmacodynamic modeling to predict the impact of CYP2C9 genetic polymorphisms, co-medication and formulation on the pharmacokinetics and pharmacodynamics of Flurbiprofen

, 2020
Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can serve as a powerful framework for predicting the influence as well as the interaction of formulation, genetic polymorphism and co-medication on the pharmacokinetics and ...
Turner, David, Dressman, Jennifer B., Ioannis Loisios-Konstantinidis, Loisios-Konstantinidis, Ioannis, Jennifer Dressman, Cristofoletti, Rodrigo, Jamei, Masoud, David Turner, Rodrigo Cristofoletti, Masoud Jamei   +9 more
core   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Genome-wide by trait interaction analyses with neuroticism reveal chronic pain-associated depression as a distinct genetic subtype

Translational Psychiatry
The frequent co-occurrence of chronic pain (CP) and depression is a well-known phenomenon, supported by both the high prevalence of major depression among CP patients and studies describing a substantial genetic correlation between the two phenotypes ...
Sandor Krause, Dora Torok, Gyorgy Bagdy, Gabriella Juhasz, Xenia Gonda   +4 more
doaj   +1 more source

Three fluoroquinolones with different epithelial lining fluid penetration in a murine lung infection model: an experimental site-specific PK/PD study

Antimicrobial Agents and Chemotherapy
Antimicrobial efficacy in pneumonia is strongly influenced by site-specific drug exposure; however, pharmacokinetic/pharmacodynamic (PK/PD) indices based on plasma concentrations may not adequately reflect drug exposure at the pulmonary infection site ...
Ayaka Hosoi, Shaoqing Duan, Sora Shimada, Kenta Suzuki, Yuki Mizukami, Ryuya Shintani, Mishu Takahashi, Natsuki Satake, Takuma Muraishi, Yuko Okamoto, Yuki Igarashi, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto   +13 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Clinical Pharmacokinetics and Pharmacodynamics of Voclosporin

, 2023
Voclosporin is an approved option for the long-term treatment of lupus nephritis. We aimed to provide a narrative review of the pharmacokinetics and pharmacodynamics of voclosporin.
Keller, Frieder, Emaad Abdel-Kahaar, Abdel-Kahaar, Emaad, Frieder Keller   +3 more
core   +1 more source