The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine. [PDF]
, 2011 Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. This is an essential issue in cancer treatment due to its high toxicity. During the last decade, cyclin-dependent kinase
Hassan, Moustapha +2 more
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, 2021 With more than 90 approved drugs by 2020, therapeutic antibodies have played a central role in shifting the treatment landscape of many diseases, including autoimmune disorders and cancers. While showing many therapeutic advantages such as long half-life
Yanguang Cao, Yu Tang
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Changes in the Pharmacokinetics and Pharmacodynamics of Sildenafil in Cigarette and Cannabis Smokers
, 2021 Sildenafil citrate, a widely-used oral therapy for erectile dysfunction, is a cytochrome P3A4 (CYP3A4) enzyme substrate. Studies have reported that this substrate has an inhibitory effect on CYP3A4 enzymes in long-term cigarette and cannabis smokers ...
Mohamed Ahmed Raslan +3 more
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Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]
, 2010 The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Färnert, Anna +46 more
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Oliceridine — a unique drug among opioid analgesics
Journal of Medical Science, 2020 Oliceridine is an opioid with a different mechanism of action compared to classical opioid agonists, e.g. morphine, as it does not act through active metabolites and activates the β-arrestin pathway to a small extent, thereby reducing dangerous side ...
Ewa Gibuła-Tarłowska +2 more
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, 2020 In the last few years, there have been significant advances in migraine management and prevention. Lasmiditan, ubrogepant, rimegepant and monoclonal antibodies (erenumab, fremanezumab, galcanezumab, and eptinezumab) are new drugs that were launched on ...
Danuta Szkutnik-Fiedler
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Impact of aminophylline on the pharmacodynamics of propofol in beagle dogs
, 2018 Aminophylline; Interaction; Pharmacodynamics; Pharmacokinetics ...
이은경
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The role of acetylcholine in drug addiction
Current Issues in Pharmacy and Medical Sciences, 2012 Acetylcholine ACh, is involved in many CNS functions like sensory and motor processing, sleep, nociception, memory, mood, stress response, attention, arousal, motivation and reward.
Kinga Gaweł +2 more
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Evaluation of dosing strategy for pembrolizumab for oncology indications
Journal for ImmunoTherapy of Cancer, 2017 Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
Tomoko Freshwater +6 more
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DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
Journal of Hematology & Oncology, 2020 Background Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins.
Yonghan He +15 more
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