Results 11 to 20 of about 77,040 (258)
BMC Genomics, 2018 Background 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) is a widely used entactogenic drug known to impair cognitive functions on the long-run. Both hippocampal and frontal cortical regions have well established roles in behavior, memory formation
Peter Petschner +6 more
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OSMOLOGY AND PHARMACODYNAMICS. [PDF]
JAMA: The Journal of the American Medical Association, 1905 Osmology is usually defined as the science treating of the osmotic states of the body fluids. However, as the osmotic processes in a liquid in a great measure reflect also its other physical conditions, this fact should be embraced in an adequate definition. Osmology, hence, may be spoken of as the knowledge concerning the physical conditions of and in
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Pharmacodynamics of fluoroquinolones [PDF]
Journal of Antimicrobial Chemotherapy, 1999 Abstract Fluctuating concentrations of three fluoroquinolones (moxifloxacin, sparfloxacin and ofloxacin) and a β-lactam (amoxycillin) were used in vitro to simulate antibiotic concentrations in human serum after oral doses of antibiotics.
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Pharmacodynamics of bisphosphonates in arthritis [PDF]
Expert Review of Clinical Pharmacology, 2011 Inflammatory arthritis is a group of autoimmune diseases characterized by chronic inflammation of the joints. Rheumatoid arthritis, the most common form of arthritis, is associated with local joint destruction and systemic bone loss. Osteoclasts, the only cells of the body able to resorbe bone, are key players in these two types of bone loss ...
Le Goff, B., Heymann, D.
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BMC Infectious Diseases, 2021 Background This systematic review and meta-analysis explored the relationship between vancomycin (VCM) monitoring strategies and VCM effectiveness and safety.
Moeko Tsutsuura +14 more
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Oliceridine — a unique drug among opioid analgesics
Journal of Medical Science, 2020 Oliceridine is an opioid with a different mechanism of action compared to classical opioid agonists, e.g. morphine, as it does not act through active metabolites and activates the β-arrestin pathway to a small extent, thereby reducing dangerous side ...
Ewa Gibuła-Tarłowska +2 more
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p-Synephrine and its various pharmacological effects
Current Issues in Pharmacy and Medical Sciences, 2021 There is a number of diseases for which, scientists are constantly looking for a promising new treatments. Isolation of novel substances with biological activity from plants gives hope for its use in treatment.
Ziemichod Wojciech +4 more
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The role of acetylcholine in drug addiction
Current Issues in Pharmacy and Medical Sciences, 2012 Acetylcholine ACh, is involved in many CNS functions like sensory and motor processing, sleep, nociception, memory, mood, stress response, attention, arousal, motivation and reward.
Kinga Gaweł +2 more
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Clinical and Translational Science, 2020 In the development of new drugs, the prediction of metabolite‐to‐parent plasma exposure ratio in humans prior to administration in a clinical study has emerged as an important need.
Ernesto Callegari +2 more
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DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
Journal of Hematology & Oncology, 2020 Background Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins.
Yonghan He +15 more
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