Results 41 to 50 of about 93,887 (308)

Pharmacotherapy of Patients Taking New Psychoactive Substances: A Systematic Review and Analysis of Case Reports

Frontiers in Psychiatry, 2021
Background: In recent years, an increase in the frequency of hospitalizations of patients taking newer and newer psychoactive substances has been observed around the world.
Michal Ordak, Aleksandra Zmysłowska, Miłosz Bielski, Daniel Rybak, Maja Tomaszewska, Katarzyna Wyszomierska, Aleksandra Kmiec, Natalia Garlicka, Maria Zalewska, Michal Zalewski, Tadeusz Nasierowski, Elzbieta Muszynska, Magdalena Bujalska-Zadrozny   +12 more
doaj   +1 more source

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

Advanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach, Reza Kowsari‐Esfahan, Emilia Reszczyńska, Philippe Nghe, Matthias Nees   +4 more
wiley   +1 more source

The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine. [PDF]

, 2011
Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. This is an essential issue in cancer treatment due to its high toxicity. During the last decade, cyclin-dependent kinase
Hassan, Moustapha, Sallam, Hatem, Hassan, Zuzana   +2 more
core  

Clinical Pharmacokinetics and Pharmacodynamics of Voclosporin

, 2023
Voclosporin is an approved option for the long-term treatment of lupus nephritis. We aimed to provide a narrative review of the pharmacokinetics and pharmacodynamics of voclosporin.
Keller, Frieder, Emaad Abdel-Kahaar, Abdel-Kahaar, Emaad, Frieder Keller   +3 more
core   +1 more source

In Silico Study of Different Thrombolytic Agents for Fibrinolysis in Acute Ischemic Stroke [PDF]

, 2023
Alteplase is the only FDA-approved drug for thrombolysis in acute ischemic stroke (AIS). Meanwhile, several thrombolytic drugs are deemed to be promising candidates to substitute alteplase.
Xu, Xiao, Yang, Yilin, Gu, Boram, Yilin Yang, Xiao Yun Xu, Boram Gu   +5 more
core   +1 more source

Larks under pressure: The genetic background of the morning chronotype may contribute to depression in interaction with stress

European Psychiatry
Introduction Depression is a highly prevalent, multifactorial, complex disorder, its etiology is assumed to involve both genetic and environmental factors.
M. Csikos, S. Krause, Z. Gal, G. Bagdy, G. Juhasz, X. Gonda, D. Torok   +6 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

The Affinity of Histamine for Gq Protein-Coupled Histamine H1-Receptors Is Predominantly Regulated by Their Internalization in Human Astrocytoma Cells

Journal of Pharmacological Sciences, 2012
We examined the regulatory mechanisms of the affinity of Gq protein-coupled histamine H1-receptors for histamine after histamine pretreatment in intact human U373 MG astrocytoma cells.
Shigeru Hishinuma, Yuko Sato, Chizuru Akatsu, Masaru Shoji   +3 more
doaj   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression

Translational Psychiatry
A recent study demonstrated that rodents exposed to early life stress (ELS) showed changes in fat tissue composition and exhibited depression-like phenotype.
Dora Torok, Sandor Krause, Kinga Gecse, Zsofia Gal, Nora Eszlari, Mate Csikos, Gyorgy Bagdy, Xenia Gonda, Gabriella Juhasz, Peter Petschner   +9 more
doaj   +1 more source