Results 41 to 50 of about 101,624 (260)
Advanced Science, EarlyView.We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen +5 more
wiley +1 more source
Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression
Translational PsychiatryA recent study demonstrated that rodents exposed to early life stress (ELS) showed changes in fat tissue composition and exhibited depression-like phenotype.
Dora Torok +9 more
doaj +1 more source
Insights into amoxicillin pharmacokinetics using physiology-based pharmacokinetic modelling
Antimicrobial Agents and ChemotherapyAmoxicillin is the most commonly used antibiotic globally. However, there is a relatively poor understanding of its pharmacokinetics, pharmacodynamics, and clinical pharmacology.
Christopher A. Darlow +3 more
doaj +1 more source
In Silico Study of Different Thrombolytic Agents for Fibrinolysis in Acute Ischemic Stroke [PDF]
, 2023 Alteplase is the only FDA-approved drug for thrombolysis in acute ischemic stroke (AIS). Meanwhile, several thrombolytic drugs are deemed to be promising candidates to substitute alteplase.
Xu, Xiao +5 more
core +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
MoleculesAlzheimer’s disease (AD) is a neurodegenerative disorder, characterized by the formation of amyloid β and tau protein aggregates in the brain, neuroinflammation, impaired cholinergic neurotransmission, and oxidative stress, resulting in the gradual loss ...
Jan Detka +4 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Serotonin 2C receptors (5-HT2CRs) are implicated in the pathomechanism and treatment of anxiety and depression. Recently, as a new biomarker of depression, alterations in the gamma power of the electroencephalogram (EEG) have been suggested.
Noémi Papp +11 more
doaj +1 more source
Advanced Science, EarlyView.Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai +10 more
wiley +1 more source
Editorial on Special Issue “Pharmacokinetics, Pharmacodynamics, and Drug Interactions”
Pharmacokinetics describes the absorption, distribution, metabolism, and excretion of a drug, while pharmacodynamics focuses on the effects of the drug on the body [...
Zhu Zhou
core +1 more source
Pharmacodynamics in paramedic practice [PDF]
Pharmacodynamics is the study of how drugs interact with the body to produce their effects, focusing on the mechanisms of drug action and their impact on physiological processes.
Thain, A, Webster, CA
core +1 more source