Results 111 to 120 of about 5,396 (178)

Integration of Liquid Handling Robotics, Turbidimetry, and Machine Learning Toward Inverse Design of Lower Critical Solution Temperature Polymer Formulations

Advanced Intelligent Systems, EarlyView.
An integrated OT‐2/plate reader platform automates LCST cloud point measurement of NIPAM‐co‐DMAEMA copolymers across high‐dimensional formulation spaces. Machine learning trained on the resulting high‐throughput datasets achieves R2 up to 0.96 and enables inverse design of polymer formulations to target transition temperatures with <1% error.
Lachlan Alexander, Vianna F. Jafari, Tanja Junkers   +2 more
wiley   +1 more source

Role of oxytocin in bone

Frontiers in Endocrinology
Oxytocin (OT) is a posterior pituitary hormone that, in addition to its role in regulating childbirth and lactation, also exerts direct regulatory effects on the skeleton through peripheral OT and oxytocin receptor (OTR).
Tianming Wang, Jianya Ye, Jianya Ye, Yongqiang Zhang, Jiayi Li, Tianxiao Yang, Yufeng Wang, Xiao Jiang, Qingqiang Yao   +8 more
doaj   +1 more source

An Adult Presentation of KIF11‐Related MCLID Syndrome: Case Report and 40‐Year Follow‐Up

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in KIF11 are linked to autosomal dominant syndromes with microcephaly, chorioretinopathy, lymphedema, and intellectual disability (MCLID), though adult presentations remain underreported. We report a 42‐year‐old female presenting with a de novo single‐amino acid in‐frame deletion in the KIF11 gene (c.1294_1296del; p ...
Thrishna Chathurvedula, Juvy Rabelas, Kareem Touleimat, Elaine Marchi, Ruhi Shah, Shaydah Kheradmand, Kuldeep Singh, Karen Amble, Gholson J. Lyon   +8 more
wiley   +1 more source

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source

Đặc điểm sinh học của nấm thán thư Colletotrichum hại cây ớt tại Củ Chi, thành phố Hồ Chí Minh [PDF]

, 2018
7 tr.Cây ớt cay (Capsium annuum L.) bị bệnh thán thư gây hại đáng kể, bệnh do một số loài nấm Colletotrichum gây ra. Tại huyện Củ Chi, bệnh gây hại trên quả trong giai đoạn trước khi thu hoạch ở vụ mưa, triệu chứng điển hình là các vết bệnh tối màu ...
Trần, Dũng Minh, Nguyễn, Thị Nhã
core   +1 more source

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

NGHIÊN CỨU TÁCH KHOÁNG SILICAT TỪ BỘT ỚT NHẰM ĐO PHỔ NHIỆT HUỲNH QUANG

, 2016
Để đo tín hiệu nhiệt huỳnh quang và xác định liều chiếu, các mẫu chiếu xạ cần phải đảm bảo tách các khoáng chất cần thiết. Phương pháp tách khoáng  yêu cầu tiến hành theo một qui trình hợp lý nhằm đảm bảo đủ lượng khoáng cho phép đo.
Sang, Nguyễn Duy
core   +1 more source

Nghiên cứu đa dạng di truyền nấm Colletotrichum spp. gây bệnh thán thư ớt tại một số tỉnh Đông Nam Bộ và Tây Nguyên

Trong các bệnh hại nghiêm trọng trên cây ớt, bệnh thán thư do nấm Colletotrichum spp. gây ra được xem là bệnh hại phổ biến có giá trị kinh tế quan trọng. Trong nghiên cứu này 32 mẫu nấm Colletotrichum spp.
Huỳnh Thường Vương, Võ Thị Ngọc Hà, Huỳnh Thanh Hùng   +2 more
core   +1 more source