Results 91 to 100 of about 5,396 (178)

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Effect of Oxytocin on Hunger Discrimination

Frontiers in Endocrinology, 2019
Centrally and peripherally administered oxytocin (OT) decreases food intake and activation of the endogenous OT systems, which is associated with termination of feeding.
Mitchell A. Head, David C. Jewett, Sarah N. Gartner, Anica Klockars, Allen S. Levine, Pawel K. Olszewski, Pawel K. Olszewski   +6 more
doaj   +1 more source

Potential‐Controlled Ammonium‐Assisted Reversible Electrodeposition of Polyoxometalates for Hybrid Redox Flow Batteries

Advanced Science, EarlyView.
Potential‐controlled NH4+‐assisted reversible electrodeposition of molecular metal oxide clusters enables dynamic solution‐to‐solid electron storage. Leveraging this deposition/dissolution reaction chemistry, polyoxometalate‐based hybrid flow batteries are demonstrated as a new platform for deposition‐based electrochemical energy storage.
Ke Wang, Nikhil Arya, Sadia Shahid, Montaha Anjass   +3 more
wiley   +1 more source

Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake

Molecular Metabolism
Objectives: Oxytocin (OT) is a neuropeptide produced in the paraventricular (PVH) and supraoptic (SON) nuclei of the hypothalamus. Either peripheral or central OT administration reduces food intake through reductions in meal size.
Jessica J. Rea, Clarissa M. Liu, Anna M.R. Hayes, Rita Ohan, Grace M. Schwartz, Alexander G. Bashaw, Molly E. Klug, Lea Decarie-Spain, Yedam Park, Alicia E. Kao, Valery Grinevich, Scott E. Kanoski   +11 more
doaj   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

An audit of attendance at occupational therapy by long-term psychiatric in-patients at Weskoppies Hospital

South African Journal of Occupational Therapy, 2011
Objectives: Although the value of occupational therapy (OT) in psychiatric rehabilitation is indisputable, little is known about the range of OT interventions attended by long-term in-patient populations.
Christa Kruger, Ronel van der Westhuizen
doaj  

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Use of an observer tool to enhance learning of anaesthesia resident’s non-technical skills during high-fidelity simulation: a randomised controlled trial

BMC Medical Education
Background The use of an observer tool (OT) has been shown to improve learning of technical skills through observation in simulation. The objective was to assess the impact of a non-technical OT on anaesthesia residents’ learning of non-technical skills (
Caroline Havard, Viridiana Jouffroy, Agnès Le Gouez, Marie Bruyère, Samy Figueiredo, Philippe Roulleau, Dan Benhamou, Aurore Margat, Antonia Blanié   +8 more
doaj   +1 more source

Salivary and blood plasma oxytocin after oxytocin injection and during machine milking in dairy cows

JDS Communications
Oxytocin (OT), the peptide hormone whose release from the pituitary is essential to induce milk ejection, has been measured in blood plasma of dairy cows for decades.
Olga Wellnitz, Benjamin Jenni, Natascha Stoffel, Samantha Weber, Selma Aybek, Rupert M. Bruckmaier   +5 more
doaj   +1 more source

Development and experimental validation of a predictive resilient framework for cyber‐physical systems

AIChE Journal, EarlyView.
Abstract Cyber‐physical process systems integrate process dynamics, control, sensing, actuation, and communication, making them vulnerable to attacks that falsify data, alter control actions, or disrupt networks and drive operations toward unsafe states.
Luyang Liu, Ritu Ranjan, Zaman Sajid, Benjamin Wilhite, Costas Kravaris, Faisal Khan   +5 more
wiley   +1 more source