Results 81 to 90 of about 4,894 (200)

Oxytocin Relieves Neuropathic Pain Through GABA Release and Presynaptic TRPV1 Inhibition in Spinal Cord

Frontiers in Molecular Neuroscience, 2018
Objective: Oxytocin (OT) is synthesized within the paraventricular nucleus and supraoptic nucleus of the hypothalamus. In addition to its role in uterine contraction, OT plays an important antinociceptive role; however, the underlying molecular ...
Wuping Sun, Qian Zhou, Xiyuan Ba, Xiaojin Feng, Xuexue Hu, Xiaoe Cheng, Tao Liu, Jing Guo, Lizu Xiao, Jin Jiang, Donglin Xiong, Yue Hao, Zixian Chen, Changyu Jiang   +13 more
doaj   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders

Frontiers in Neuroanatomy, 2015
Oxytocin (OT), the main neuropeptide of sociality, is expressed in neurons exclusively localized in the hypothalamus. During the last decade, a plethora of neuroendocrine, metabolic, autonomic and behavioral effects of OT has been reported.
Valery eGrinevich, Michel eDesarménien, Bice eChini, Maithé eTauber, Françoise eMuscatelli   +4 more
doaj   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

ẢNH HƯỞNG CỦA BỐN LOẠI GỐC GHÉP ỚT ĐẾN SINH TRƯỞNG VÀ NĂNG SUẤT ỚT SỪNG VÀNG CHÂU PHI (CAPSICUM SPP.)

Tạp chí Khoa học Đại học Cần Thơ, 2014
Mục tiêu của nghiên cứu nhằm xác định gốc ghép thích hợp với ngọn ghép ớt Sừng vàng Châu Phi. Thí nghiệm được bố trí theo thể thức khối hoàn toàn ngẫu nhiên với 3 lần lặp lại gồm 5 nghiệm thức gốc ghép với ngọn ớt Sừng vàng Châu Phi là (1) ớt Hiểm trắng,
Võ Thị Bích Thủy, Dương Phát Thịnh, Trần Thị Ba   +2 more
doaj  

The organizational effects of oxytocin on the central expression of estrogen receptor α and oxytocin in adulthood

BMC Neuroscience, 2007
Background Previous studies have demonstrated that neonatal manipulation of oxytocin (OT) has effects on the expression of estrogen receptor α (ERα) and the central production of oxytocin observed in juveniles (at weaning, 21 days of age).
Papademetriou Eros, Yoshida Shigeto, Kramer Kristin M, Cushing Bruce S   +3 more
doaj   +1 more source

Psychometric properties and factor structure of the Vietnamese Copenhagen Burnout Inventory. [PDF]

J Occup Health, 2023
Tran TTT, Nguyen QT, Nguyen NT, Vu ST, Kaewboonchoo O, Kawakami N, Nguyen HT.   +6 more
europepmc   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source

Salivary and blood plasma oxytocin after oxytocin injection and during machine milking in dairy cows

JDS Communications
Oxytocin (OT), the peptide hormone whose release from the pituitary is essential to induce milk ejection, has been measured in blood plasma of dairy cows for decades.
Olga Wellnitz, Benjamin Jenni, Natascha Stoffel, Samantha Weber, Selma Aybek, Rupert M. Bruckmaier   +5 more
doaj   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source