Results 41 to 50 of about 64,314 (215)

Imaging Indicators for Parenchymal Hemorrhage After Mechanical Thrombectomy in Acute Stroke

Stroke: Vascular and Interventional Neurology, 2023
Background In patients with acute ischemic stroke with large vessel occlusion, the presence of hyperintense lesions on fluid‐attenuated inversion recovery (FLAIR‐positive) before mechanical thrombectomy (MT) and that of hyperdense lesions on noncontrast ...
Ryutaro Kimura, Sotaro Shoda, Tomonari Saito, Kentaro Suzuki, Akihito Kutsuna, Takuya Kanamaru, Takehiro Katano, Toru Nakagami, Shinichiro Numao, Satoshi Suda, Yasuhiro Nishiyama, Kazumi Kimura   +11 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Focal T2 and FLAIR hyperintensities within the infarcted area: A suitable marker for patient selection for treatment? [PDF]

PLoS ONE, 2017
Some authors use FLAIR imaging to select patients for stroke treatment. However, the effect of hyperintensity on FLAIR images on outcome and bleeding has been addressed in only few studies with conflicting results.466 patients with anterior circulation ...
Julia Meisterernst, Pascal P Klinger-Gratz, Lars Leidolt, Matthias F Lang, Gerhard Schroth, Pasquale Mordasini, Mirjam R Heldner, Marie-Luise Mono, Rebekka Kurmann, Monika Buehlmann, Urs Fischer, Marcel Arnold, Jan Gralla, Heinrich P Mattle, Marwan El-Koussy, Simon Jung   +15 more
doaj   +1 more source

FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma

Brain Sciences, 2022
The standard of care for isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) is maximal resection followed by chemotherapy and radiation. Studies investigating the resection of GBM have primarily focused on the contrast enhancing portion of the ...
Alexander F. Haddad, Jacob S. Young, Ramin A. Morshed, Mitchel S. Berger   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Application of three-dimensional fluid-attenuated inversion recovery sequence using artificial intelligence-assisted compressed sensing technique in intravenous gadolinium contrast-enhanced magnetic resonance imaging of inner ear

Zhongguo Linchuang Yixue
ObjectiveTo investigate the value of artificial intelligence-assisted compressed sensing (ACS) technology for intravenous gadolinium contrast-enhanced magnetic resonance imaging of the inner ear using three-dimensional fluid-attenuated inversion recovery
Kai LIU, Jian WANG, Huaili JIANG, Shujie ZHANG, Di WU, Xinsheng HUANG, Mengsu ZENG, Menglong ZHAO   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A single model for glioblastoma segmentation with and without T2-FLAIR: independent validation of a targeted dropout strategy

Frontiers in Neurology
ObjectivesTo evaluate targeted T2 fluid-attenuated inversion recovery (T2-FLAIR) dropout for robust automated glioblastoma segmentation and volumetry when T2-FLAIR is unavailable, while preserving performance when the full MRI protocol is available ...
Marco Öchsner, Lena Kaiser, Robert Stahl, Nathalie L. Albert, Nathalie L. Albert, Nathalie L. Albert, Thomas Liebig, Robert Forbrig, Jonas Reis   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source