Results 51 to 60 of about 79,889 (252)

Meningeal contrast enhancement in multiple sclerosis: Assessment of field strength, acquisition delay, and clinical relevance.

PLoS ONE
Background/purposeLeptomeningeal enhancement (LME) on post-contrast FLAIR is described as a potential biomarker of meningeal inflammation in multiple sclerosis (MS).
Daniel M Harrison, Yohance M Allette, Yuxin Zeng, Amanda Cohen, Shishir Dahal, Seongjin Choi, Jiachen Zhuo, Jun Hua   +7 more
doaj   +1 more source

Hyperintensity of Cerebrospinal Fluid on T2-Weighted Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging Caused by High Inspired Oxygen Fraction

Frontiers in Veterinary Science, 2017
In veterinary medicine, patients undergo magnetic resonance imaging (MRI) under general anesthesia to enable acquisition of artifact-free images. The fraction of inspired oxygen (FiO2) ranges between 30 and 95%.
Melania Moioli, Olivier Levionnois, Veronika M. Stein, Gertraud Schüpbach, Marta Schmidhalter, Daniela Schweizer-Gorgas   +5 more
doaj   +1 more source

-----Comparison of T1-Post and FLAIR-Post MRI for identification of traumatic meningeal enhancement in traumatic brain injury patients.

PLoS ONE, 2020
Traumatic meningeal enhancement (TME) is a novel biomarker observed on post-contrast fluid-attenuated inversion recovery (FLAIR) in patients who undergo contrast-enhanced magnetic resonance imaging (MRI) after suspected traumatic brain injury (TBI).
Tara S Davis, Jennifer E Nathan, Ana S Tinoco Martinez, Jill B De Vis, L Christine Turtzo, Lawrence L Latour   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

DWI intensity values predict FLAIR lesions in acute ischemic stroke. [PDF]

PLoS ONE, 2014
BACKGROUND AND PURPOSE: In acute stroke, the DWI-FLAIR mismatch allows for the allocation of patients to the thrombolysis window (
Vince I Madai, Ivana Galinovic, Ulrike Grittner, Olivier Zaro-Weber, Alice Schneider, Steve Z Martin, Federico C von Samson-Himmelstjerna, Katharina L Stengl, Matthias A Mutke, Walter Moeller-Hartmann, Martin Ebinger, Jochen B Fiebach, Jan Sobesky   +12 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Imaging Indicators for Parenchymal Hemorrhage After Mechanical Thrombectomy in Acute Stroke

Stroke: Vascular and Interventional Neurology, 2023
Background In patients with acute ischemic stroke with large vessel occlusion, the presence of hyperintense lesions on fluid‐attenuated inversion recovery (FLAIR‐positive) before mechanical thrombectomy (MT) and that of hyperdense lesions on noncontrast ...
Ryutaro Kimura, Sotaro Shoda, Tomonari Saito, Kentaro Suzuki, Akihito Kutsuna, Takuya Kanamaru, Takehiro Katano, Toru Nakagami, Shinichiro Numao, Satoshi Suda, Yasuhiro Nishiyama, Kazumi Kimura   +11 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Perbedaan Intensitas Penyengatan Meningeal Hasil MRI antara Sekuens T2 FLAIR Post Contrast dan T1WI Post Contrast Gadolinium-DTPA dalam Mendeteksi Penyangatan Meningeal pada Kasus Meningitis Tuberkulosis

Majalah Kedokteran Bandung, 2017
Diagnosis meningitis TB terutama pada kasus possible dan probable sulit ditegakkan. Pemeriksaan MRI kepala dengan kontras Gadolinium-DTPA adalah modalitas radiologi yang paling sensitif untuk membantu mendiagnosis penyakit ini.
Arie Hendarin, Rista D. Soetikno, Harry Galuh Nugraha   +2 more
doaj   +1 more source