Results 81 to 90 of about 161,763 (251)

The Diagnostic Utility of Contrast-Enhanced FLAIR Imaging in the Diagnosis of Pediatric Uveitis

Journal of the Belgian Society of Radiology
Objectives: Contrast-enhanced FLAIR fat-suppressed (CE-FLAIR-FS) imaging can potentially increase the diagnostic accuracy of uveal diseases and ultimately provide better patient management.
Saffet Ozturk, Esin Kurtulus Ozturk, Yasemin Tasci Yildiz, Bahadir Konuskan   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Simultaneous synthesis of FLAIR and segmentation of white matter hypointensities from T1 MRIs

, 2018
Segmenting vascular pathologies such as white matter lesions in Brain magnetic resonance images (MRIs) require acquisition of multiple sequences such as T1-weighted (T1-w) --on which lesions appear hypointense-- and fluid attenuated inversion recovery ...
Cardoso, M. Jorge, Modat, Marc, Nielsen, Mads, Orbes-Arteaga, Mauricio, Ourselin, Sébastien, Pai, Akshay, Sørensen, Lauge   +6 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Radiomics models identifying dementia in patients with normal age-related hippocampal atrophy: a study based on machine learning

BMC Geriatrics
Methods Our study aimed to employ a machine learning models based on radiomics for automated dementia identification in cerebral small vessel disease (CSVD) patients with normal age-related hippocampal atrophy (HA).
Xiao-Li Yang, Yu-Fan Luo, Sheng-Wen Huang, Chen Li, Yuan-Yuan Wang, Huang-Huang Huang, Meng-Xiang Wang, Wen-Mei Lu, Ping-Ping Zong, Hu-Lie Zeng, Dan-Hong Wu   +10 more
doaj   +1 more source

Ultrafast Brain MRI at 3 T for MS: Evaluation of a 51-Second Deep Learning-Enhanced T2-EPI-FLAIR Sequence

Diagnostics
In neuroimaging, there is no equivalent alternative to magnetic resonance imaging (MRI). However, image acquisitions are generally time-consuming, which may limit utilization in some cases, e.g., in patients who cannot remain motionless for long or ...
Martin Schuhholz, Christer Ruff, Eva Bürkle, Thorsten Feiweier, Bryan Clifford, Markus Kowarik, Benjamin Bender   +6 more
doaj   +1 more source

MRI Tumor Segmentation with Densely Connected 3D CNN

, 2018
Glioma is one of the most common and aggressive types of primary brain tumors. The accurate segmentation of subcortical brain structures is crucial to the study of gliomas in that it helps the monitoring of the progression of gliomas and aids the ...
Abidin, Anas Z., Chen, Lele, DSouza, Adora M., Wismuller, Axel, Wu, Yue, Xu, Chenliang   +5 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Role of the T2–FLAIR Mismatch Sign as an Imaging Marker of IDH Status in a Mixed Population of Low- and High-Grade Gliomas

Brain Sciences, 2020
Our study evaluated the role of the T2–fluid-attenuated inversion recovery (FLAIR) mismatch sign in detecting isocitrate dehydrogenase (IDH) mutations based on a mixed sample of 24 patients with low- and high- grade gliomas.
Eftychia Z. Kapsalaki, Alexandros G. Brotis, Alexandra Tsikrika, Christos Tzerefos, Thanos Paschalis, Efthymios Dardiotis, Konstantinos N. Fountas   +6 more
doaj   +1 more source