Results 31 to 40 of about 1,308,137 (220)
Soap Bubbles in Outer Space: Interaction of a Domain Wall with a Black Hole [PDF]
, 1998 We discuss the generalized Plateau problem in the 3+1 dimensional Schwarzschild background. This represents the physical situation, which could for instance have appeared in the early universe, where a cosmic membrane (thin domain wall) is located near a
A. L. Larsen +20 more
core +3 more sources
The Bi-Compact-Open Topology on C(X)
, 2016 For the set C(X) of real-valued continuous functions on a Tychonoff space X, the compact-open topology on C(X) is a "set-open topology". This paper studies the separation and countability properties of the space C(X) having the topology given by the join
Jindal, Anubha, Kundu, S., McCoy, R. A.
core +1 more source
Error-Correcting Codes on Projective Bundles over Deligne–Lusztig Varieties
Mathematics, 2023 The aim of this article is to give lower bounds on the parameters of algebraic geometric error-correcting codes constructed from projective bundles over Deligne–Lusztig surfaces.
Daniel Camazón Portela +1 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
DEGENERATE DISTRIBUTED CONTROL SYSTEMS WITH FRACTIONAL TIME DERIVATIVE
Ural Mathematical Journal, 2016 The existence of a unique strong solution for the Cauchy problem to semilinear nondegenerate fractional differential equation and for the generalized Showalter–Sidorov problem to semilinear fractional differential equation with degenerate operator at the
Marina V. Plekhanova
doaj +1 more source
Dual-topology insertion of a dual-topology membrane protein. [PDF]
, 2015 Some membrane transporters are dual-topology dimers in which the subunits have inverted transmembrane topology. How a cell manages to generate equal populations of two opposite topologies from the same polypeptide chain remains unclear.
Bowie, James U +2 more
core
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source