Chinese expert consensus on immunotherapy for gynecological malignant tumors (2023 edition) [PDF]
, 2023 Immunotherapy, as the fourth largest anti-tumor treatment method, has made breakthrough progress in the field of cancer treatment. Checkpoint inhibitors have been widely used in the treatment of various malignant tumors, and a lot of clinical evidence ...
Society of Onco-Endocrinology of Chinese Anti-Cancer Association
core +1 more source
Test and Significance of CEA, NSE, CA125, CYFRA21-1 in Lung Cancer [PDF]
, 2017 目的 探讨CEA、NSE、CA125、CYFRA21-1在肺癌中的检测及意义.方法 回顾性分析2015年10月—2016年12月医院收治的肺部疾病患者166例,其中89例肺癌患者设为肺癌组,其余77例肺部良性病变患者设为肺部良性病变组.另选择35名健康志愿者作为健康对照组,电化学发光法检测3组血清中CEA、NSE、CA125、CYFRA21-1含量,分析单项及联合检测对肺癌的诊断价值.结果 肺癌组患者血清CEA、NSE、CA125、CYFRA21-1分别为（4.32±0.83）ng/mL、（11.54 ...
何佳瑜, 何正, 罗世翊, 魏玲
core +1 more source
Preliminary study on the role and mechanism of ISG15 in exosomes in platinum resistance in ovarian cancer [PDF]
Background and purpose: Epithelial ovarian cancer (EOC) has a poor prognosis and is prone to developing resistance to platinum-based chemotherapy. Exosomes are currently believed to be involved in platinum resistance in ovarian cancer.
TIAN Yanan, ZHENG Hui, YAN Tianqing, ZHANG Heng, LU Renquan, GUO Lin
core +1 more source
Mirk/Dyrk1b在上皮性卵巢癌组织中的表达及意义 [PDF]
, 2011 目的:探讨Mirk/Dryk1b(Minibrain-related kinase/Dual specificity tyrosine-phosphorylation-regulated kinase1B)在卵巢组织中的表达及其临床意义。方法:利用免疫组化检测Mirk/Dyrk1b在30例上皮性卵巢癌、20例上皮性卵巢囊腺瘤、10例正常卵巢组织中的表达。结果:Dyrk1b在上皮性卵巢癌中的表达明显高于上皮性卵巢囊腺瘤及正常卵巢组织(P0.05)。结论:Dyrk1b在上皮性卵巢癌中高表达 ...
廖洪锋 +7 more
core
The expression and pathological significance of Dyrk1b/Mirk in ovarian cancer [PDF]
, 2012 目的 卵巢癌是常见的妇科恶性肿瘤，其中60%-90%是上皮性肿瘤。但缺乏有效的早期诊断与治疗的方法，目前临床上多采用肿瘤标志物如CA125、CA199、AFP等，结合影像学检查结果作为诊断的标准，绝大部分患者在确诊时已经发生了远处转移。手术后由于肿瘤细胞的耐药性问题使患者的5年存活率不到30%，是妇科肿瘤中死亡率较高的恶性肿瘤。因此寻找其早期诊断与治疗的新的靶基因成为迫切需要。 Dyrk1b是一种丝氨酸/苏氨酸蛋白激酶，属于Dyrk家族，有研究证实Dyrk1b在调节细胞周期 ...
胡文峰
core
Recent Advances and Strategies in the Development of Therapeutic Radiopharmaceuticals [PDF]
Therapeutic radiopharmaceuticals can be employed in the treatment of various tumor diseases，and their global market share is likely to witness an explosive growth in the recent decade.
Hao CHEN +8 more
core +1 more source
BAG Family Gene and Its Relationship with Lung Adenocarcinoma Susceptibility [PDF]
, 2010 Background and objective BAG genes (Bcl-2-associated athanogene) belong to a recently discovered multifunctional anti-apoptosis gene family that regulate various physiological processes which include apoptosis, tumorigenesis, neural differentiation ...
Heng WU +9 more
core
Effect of miR-181c-5p on vasculogenic mimicry in ovarian cancer stem-like cells and its mechanism [PDF]
Objective To investigate the effect of miR-181c-5p on vasculogenic mimicry (VM) in ovarian cancer stem-like cells (OCS-LCs) and its mechanism. Methods OVCAR3 cells were induced into OCS-LCs by serum-free suspension culture. OVCAR3 cells were divided into
WU Yingying, WEN Xiaoling, XIA Yufang, YU Xiao, LOU Yanhui
core +1 more source
Zhongguo shiyan zhenduanxue, 2011 目的探讨上皮性卵巢癌组织中组蛋白去乙酰化酶1（HDAC1）的表达及临床意义。方法采用免疫组化SP法,测定40例上皮性卵巢癌组织2、0例交界性卵巢肿瘤,20例卵巢良性肿瘤以及10例正常卵巢组织中HDAC1的表达。结果 HDAC1在在卵巢组织中的阳性表达H-score评分均随组织异型程度的增加而逐渐增高,即正常卵巢组织（1.300±0.948 68）和卵巢良性肿瘤（1.750±0.786 40）
贾妍 +4 more
doaj
Research advances in platinum resistance and its treatment in ovarian cancer [PDF]
Ovarian cancer is one of the most malignant gynecological tumors. Platinum-based chemotherapy is an important part of ovarian cancer treatment, with platinum resistance as a difficult problem in ovarian cancer treatment. Platinum resis-tance is a complex
LIU Yan, HUANG Li
core +1 more source