Results 31 to 40 of about 42,237 (197)

宇宙黑暗时代探路者−鸿蒙计划

Kongjian kexue xuebao, 2023
低频射电探测任务构想——鸿蒙计划旨在利用多颗卫星绕月编队形成超长波天文观测阵列，在月球背面开展空间低频射电天文探测。其科学目标是高精度测量全天射电频谱，揭示宇宙黑暗时代与黎明的演化历史；实现首次高分辨率超长波巡天，打开最后一个电磁窗口；观测太阳和行星超长波活动，揭示空间环境相互作用规律。该任务将获得超长波频段全天空图像，获取超长波波段天文射电源的强度、频谱、分布等信息。这些科学数据对于探索宇宙黑暗时代和黎明时代、研究银河系星际介质、宇宙线起源与传播、河外射电星系、类星体和星系团的演化 ...
陈 学雷, 阎 敬业, 徐 怡冬, 邓 丽, 吴 锋泉, 武 林, 周 莉, 张 晓峰, 朱 晓铖, 杨 中光, 吴 季   +10 more
doaj   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

空间物理学科发展战略研究

Kongjian kexue xuebao, 2023
空间物理学是人类进入空间时代后迅速发展起来的一门新兴的多学科交叉的前沿基础学科。其将太阳和太阳风控制的日球层空间作为一个系统，研究太阳/太阳风与行星/彗星的上层大气、电离层、磁层乃至星际介质之间的相互作用。空间物理学从本质上讲是一门实验科学，空间物理探测是空间物理学发展的基础。进入新世纪，随着空间基础设施和人类高技术活动的日益频繁，空间物理学进入新的发展阶段，强调科学与应用的密切结合。近年来，空间物理学取得了一系列重要进展。本文对接国家自然科学基金委地球科学部“宜居地球−地球系统科学”的顶层战略设计 ...
王 赤, 汪 毓明, 田 晖, 李 晖, 倪 彬彬, 符 慧山, 雷 久侯, 薛 向辉, 崔 峻, 尧 中华, 罗 冰显, 张 效信, 张 爱兵, 张 佼佼, 李 文亚   +14 more
doaj   +1 more source

Thermoelectric PANI/TeNWs Fiber Based Microsensor for Passive Temperature and Active Chemical Sensing

Advanced Science, EarlyView.
Continuous wet‐spinning of PANI with TeNWs yields a multifunctional microfiber. Oriented TeNWs impose chain alignment and enhance π‐electron delocalization, boosting the Seebeck coefficient to 59.9 µV K−1 for passive temperature sensing (1 K detection limit), while achieving high pH sensitivity (59.25 mV pH−1) and rapid NH3 response (0.96 s).
Dongmei Xie, Mengran Chen, Xuefei Zhang, Yan Xu, Weiye Geng, Zhe Tang, Si‐ze Lou, Shun Wan, Zhenguo Liu, Heng Liu, Peng‐an Zong   +10 more
wiley   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Computation‐Guided Tunnel Engineering Enhances O2 Transport and H2O2 Resistance of Fe(II)/α‐Ketoglutarate‐Dependent Dioxygenases

Advanced Science, EarlyView.
This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu, Lunjie Wu, Liying Mao, Songyin Zhao, Hu Liu, Shiyi Xin, Donglin Zhao, Jie Gu, Yan Xu, Xinye Wang, Yao Nie   +10 more
wiley   +1 more source

Divergent Synthesis of Möbius and Hückel N‐Heterocycloarenes From a Common Macrocyclic Backbone

Angewandte Chemie, EarlyView.
In the divergent synthesis of Möbius and Hückel N‐heterocycloarenes from a common macrocyclic precursor, the annulation reaction dictates topology: Scholl reaction gives Möbius topology, while InCl3‐mediated alkyne annulation gives Hückel topology. The Möbius N‐heterocycloarene is unevenly contorted as revealed by crystal structure, and the Hückel N ...
Han Chen, Huishu Ma, Daiyue Yang, Zheng Zhou, Xiao Chen, Zhifeng Huang, Qian Miao   +6 more
wiley   +2 more sources

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Revisiting Coulombic Efficiency Paradigm: Electrolyte Additive Design for Lithium Metal Batteries

Angewandte Chemie, EarlyView.
Coulombic efficiency (CE) is a key metric for screening advanced electrolyte formulations for rechargeable batteries. Combined with interphasial characterizations, statistical analyses of CE data uncover the synergistic interaction between fluorinated additives and salt anions, enabling more precise correlations of chemical functionalities with ...
Qixin Wang, Jiaxun Yang, Pu Li, Kun Zhao, Xinxin Zhang, Bowen Zheng, Qiangfu Sun, Zhongyang Zhang, Wenfang Feng, Javier Carrasco, Hailong Yu, Gebrekidan Gebresilassie Eshetu, Egbert Figgemeier, Michel Armand, Xuejie Huang, Zhibin Zhou, Heng Zhang   +16 more
wiley   +2 more sources