中药活性成分或活性成分群筛选是阻碍中药现代化进程的瓶颈。定量模式活性关系(Quantitative pattern-activity relationship,QPAR)是研究量效之间关系的方法,是一门整合植物化学,分析化学,数学和生物学的交叉学科,本文基于此从不同方向上发展了一套完整的可用于中药活性成分及成分群筛选的方法。通过将该方法应用到中药淫羊藿和狼毒上,取得结果列举如下: 发展了快速分析中药淫羊藿和狼毒的HPLC及UPLC-Q-Tof方法,分析时间短,灵敏度高,对大部分成分的分离度较大 ...
杨乾栩
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