Results 31 to 40 of about 19,833 (168)

Studies of the regulatory mechanism on myocardial related genes of Rbm24 [PDF]

open access: yes, 2015
实验目的 研究在心肌细胞分化和发育过程中,Rbm24蛋白发挥功能和产生的影响。寻找Rbm24结合的相关基因的不同水平的RNA,以及结合目的RNA后所发挥的功能,为降低Rbm24的表达导致扩张性心肌病等一系列心肌受损和功能紊乱相关疾病探究原因,寻找相关的信号通路,提供一定的实验及理论依据,为成功解决心脏疾病难题寻找重要的攻克点。 方法 通过Westernblot免疫印迹检测Rbm24和其他心肌相关蛋白在C2C12细胞分化中蛋白的表达情况 ...
杨康
core  

TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells [PDF]

open access: yes, 2016
溶血卵磷脂(lysophosphatidylcholine,lysoPC)是氧化低密度脂蛋白(oxidizedlow-densitylipoprotein,ox-LDL)的主要成分。早期的研究表明,lysoPC可诱导人冠状动脉平滑肌细胞(humancoronaryarterysmoothmusclecells,HCASMCs)凋亡,但具体机制尚不清楚。近期,我们通过细胞活力测定,流式细胞术,共聚焦显微镜及分子生物学手段对lysoPC作用的分子机制进行研究发现,lysoPC可引发细胞外钙离子内流 ...
王渊
core   +1 more source

An experimental approach to assess the combined effects of multiple stressors on a large vertebrate species

open access: yesConservation Biology, EarlyView.
Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta   +24 more
wiley   +1 more source

Study on Water Evaporation of Ultrasonic Vacuum Freeze Drying Yogurt(超声波强化真空冷冻干燥酸奶中水分蒸发的研究) [PDF]

open access: yesShipin kexue jishu xuebao, 2014
In this study, ultrasonic and vacuum freeze drying were combined to dry yogurt. Compared with the vacuum freeze drying, the effects of ultrasonic time, power, and pulse on water evaporation and drying time of yogurt were determined. Meanwhile, the drying
YANG Ju-fang(杨菊芳)   +4 more
doaj   +1 more source

On the Evaluation Mechanism of EU Risk Decision-making [PDF]

open access: yes, 2016
风险规制是21世纪行政法学较为前沿的研究课题。风险规制一般包括风险评估、风险管理以及风险交流三方面内容。本文所研究的欧盟风险决策的评价机制,属于风险评估事后层面的范畴。鉴于欧盟在2015年5月19日颁布的《更好规制指引》,该指引开创性的将评价机制作为风险决策过程中独立的分析工具,正式建立其统一、规范的评价机制。本文通过对欧盟委员会相关文件报告的梳理分析,从评价机制的演变过程、法律框架、组织架构、运行程序以及委员会下属各司具体评价实践情况等方面,加深对欧盟风险决策评价机制的认识 ...
林煜
core  

Calibration of the species threat abatement and restoration metric's threat abatement component in a Costa Rican landscape

open access: yesConservation Biology, EarlyView.
Abstract Achieving global conservation policy goals requires the ability to set and measure progress toward science‐based targets for biodiversity. The species threat abatement and restoration (STAR) metric was developed to enable actors to set science‐based targets for species.
Louise Mair   +17 more
wiley   +1 more source

Risk Management and Control Issues for Service Outsourcing in Logistics Support Industry [PDF]

open access: yes, 2015
摘要 服务外包作为一种现代新兴产业,适应了目前全球经济一体化,社会分工细致化的趋势,成为当下学术研究的热点和企业实践争相仿效的对象。但是在服务外包的实务中暴露出的许多风险监控的漏洞和难点,也成为了进一步推进我国服务外包产业发展深度和广度的瓶颈。 作为我国国民经济支柱的物流辅助业的服务外包问题研究也是近年来的业内降低成本,提升企业核心竞争力的竞争策略筹划的新趋势,虽然起步较晚,但是由于行业本身的涉外程度较高,所以推进速度很快。有感于此,本文从服务外包的发包企业的角度出发 ...
吴文燕
core  

Drivers of bat researchers’ intent to adopt field hygiene practices

open access: yesConservation Biology, EarlyView.
Abstract Infectious disease is a growing threat to wildlife, with zoonotic transmission most likely at the human–wildlife interface. One underappreciated activity at this interface is fieldwork with wild animals, but associated risks can be mitigated through field hygiene (FH) practices, such as using personal protective equipment and other appropriate
Joanna L. Coleman   +6 more
wiley   +1 more source

Effects of olive oil on osteoporosis after artificial menopause [PDF]

open access: yes, 2015
随着妇科恶性肿瘤发病率的逐年上升及越趋年轻化,给社会和家庭带来了巨大的经济和精神负担。妇科恶性肿瘤主要以手术为主,并辅以放化疗。随着手术切除双侧卵巢及放化疗对卵巢损害的发生,将会导致雌激素急剧下降,从而增加骨质疏松症的发病率。目前激素替代疗法(hormonereplacementtherapy,HRT)广泛用于防治人工绝经后骨质疏松症,但是有临床大样本研究表明,HRT虽然能够减缓绝经后骨质疏松症的发生,但也增加了心血管疾病、乳腺癌、中风、糖尿病、宫颈癌、子宫内膜癌、卵巢癌等的发病率 ...
刘慧兰
core  

Overlap of nonbreeding wandering albatrosses with fisheries and implications for colony‐specific population trajectories at South Georgia

open access: yesConservation Biology, EarlyView.
Abstract Bycatch in fisheries is one of the most serious threats to pelagic seabirds, causing major population declines. Mitigation measures can reduce bycatch substantially, but many fisheries fail to apply best practices, and seabird mortality remains high.
V. Warwick‐Evans   +2 more
wiley   +1 more source

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