Zhongguo shiyan zhenduanxue, 2006 目的获得重组HBx蛋白,检测乙型肝炎患者血清抗HBx抗体并探讨其临床意义。方法利用分子克隆技术克隆HBVX基因构建PET32aHBX原核表达载体,表达和纯化HBx蛋白,用该重组蛋白建立检测抗HBx抗体的间接ELISA方法;采用该ELISA分别检测正常人组、急性肝炎组、慢性肝炎组、肝硬化组和肝细胞癌组患者血清中的抗HBx抗体。结果获得具有免疫原性的HBx融合蛋白;ELISA检测表明,慢性肝炎组、肝硬化组和肝细胞癌组的抗HBx抗体的水平均高于急性肝炎组,差异具有显著性;在这三组之间 ...
任锋 +6 more
doaj
[Analysis of antiviral efficacy in pediatric patients with HBeAg-negative chronic hepatitis B]. [PDF]
Zhonghua Gan Zang Bing Za ZhiGuo X +8 more
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[Construction of a highly efficient HBV infection cell model based on HBV co-receptor neuropilin-1]. [PDF]
Zhonghua Gan Zang Bing Za ZhiLiu ZH, He XM, Xu KX, Yu HB, Chen J.
europepmc +1 more source
[Expert consensus on the management process within medical institutions for patients with hepatitis B virus infection]. [PDF]
Zhonghua Gan Zang Bing Za ZhiAuthor Group of Expert Consensus.
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[Dynamic changes of HBsAb and its predictive value in patients with chronic hepatitis B receiving antiviral therapy for clinical cure]. [PDF]
Zhonghua Gan Zang Bing Za ZhiYang HY +10 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1992 用免疫组织化学桥联酶标APAAP法和PAP法对各型乙型肝炎113例检测了肝内的HLA-Ⅰ、Ⅱ类抗原、T细胞亚群、HBsAg和HBcAg,同时测定血清HBV DNA（斑点杂交）和β2微球蛋白（RIA）。结果表明;急性肝炎、慢性活动性肝炎、重症肝炎患者的肝细胞HLA-Ⅰ、Ⅱ类抗原表达增强,尤以Ⅰ类抗原明显,慢性迁延性肝炎则几乎无表达。肝细胞HLA-Ⅰ类抗原表达与肝内炎症反应、肝细胞膜型HBSAg和浆膜型HBcAg关系密切,肝内活动性病变主要浸润细胞为CD2+细胞,CD0+细胞构成主要的细胞亚群 ...
doaj
[Clinical research advances for small-molecule nucleic acid drugs in the treatment of chronic hepatitis B]. [PDF]
Zhonghua Gan Zang Bing Za ZhiWang WX +4 more
europepmc +1 more source
[The partial cure represents an intermediate endpoint on the path to a functional cure, not an ideal endpoint]. [PDF]
Zhonghua Gan Zang Bing Za ZhiZhuang H.
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[Chinese expert consensus on clinical practice of chronic hepatitis B functional (clinical) cure]. [PDF]
Zhonghua Gan Zang Bing Za ZhiAuthor Group of Expert Consensus.
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