干扰素干预HBeAg阴性乙型肝炎疗效中血清HBsAg定量检测的意义
Zhongguo shiyan zhenduanxue, 2012 我国属HBV感染高流行区,据2006年全国人群乙肝血清流行病学调查,由于乙肝疫苗预防接种工作的开展,我国1-59岁一般人群的乙型肝炎表面抗原（Hepatitis B surface antigen,HBsAg）携带率已由9.75%降至7.18%[1]。但由于我国的人口基数大,HBV感染及所致疾病仍然是一个严重的社会公共卫生问题。慢性乙型肝炎（Chronic hepatitis B,CHB）主要为抗病毒干预,干扰素和核苷（酸）类似物为临床干预一线用药 ...
黄成河, 杨国敬
doaj
ABCA6基因的变异p.Asn1322Ser与ABCA7基因的变异 p.Cys1988Phe与抵抗慢性乙型肝炎病毒感染相关
Zhongshan Daxue xuebao. Yixue kexue ban, 2016 【目的】本课题组前期通过筛选99例理论上为“乙肝易感个体”及90例理论上为“乙肝抵抗个体” 的全外显子组测序数据，报道了乙肝病毒受体基因SLC10A1的变异p.Ser267Phe与携带者对乙肝有更高的抵抗性相关。本研究旨在进一步深度挖掘这些个体的全外显子组测序结果，鉴定以前未知的其他与慢性乙型病毒性肝炎病毒感染抵抗性相关的新基因及突变。【方法】从全外显子组测序的数据中筛选导致编码蛋白改变的单核苷酸变异和小的插入缺失；选择在“乙肝抵抗”组中显著性升高的遗传变异；用Fisher精确检验进行“易感-抵抗 ...
蒋丹华 +3 more
doaj
[One-Step Detection of Human Influenza B Virus Through Recombinase Polymerase Amplification and CRISPR/Cas12a Protein]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanYang R +9 more
europepmc +1 more source
[Icariside Ⅱ Inhibits Hepatitis B Virus and Modulates Mitochondrial Fission <i>in vitro</i>]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLiu Z +6 more
europepmc +1 more source
Advances on molecular mechanism of hepatitis B virus-induced hepatocellular carcinoma. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2021 Shao Y +4 more
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[Altered oral microbiome and metabolites are associated with improved lipid metabolism in HBV-infected patients with metabolic dysfunction-associated fatty liver disease]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang J +9 more
europepmc +1 more source
[Chronic HBV infection affects health-related quality of life in pregnant women in the second and third trimesters and postpartum period: a prospective cohort study]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoDeng Y +8 more
europepmc +1 more source