核苷(酸)类似物治疗慢性HBV感染者至HBV DNA阴转后ALT异常的因素分析
【目的】 探明慢性乙型肝炎病毒(HBV)感染者接受核苷(酸)类似物(NA)治疗至HBV DNA降至不可检测水平后,丙氨酸氨基转移酶(ALT)仍然异常的高危因素。【方法】2006年1月至2014年2月期间,回顾加前瞻性随访核苷(酸)类似物初始治疗至HBV DNA阴转(<20 IU/mL)后的慢性HBV感染者(n = 388),对比ALT复常者(n= 298)及异常者[n = 90;定义为在每1 ~ 3个月的随访间隔中,连续2次以上ALT > 40 U/L(男)或 > 35 U/L(女)]的临床特征 ...
doaj
[Construction of a highly efficient HBV infection cell model based on HBV co-receptor neuropilin-1]. [PDF]
Liu ZH, He XM, Xu KX, Yu HB, Chen J.
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[The partial cure represents an intermediate endpoint on the path to a functional cure, not an ideal endpoint]. [PDF]
Zhuang H.
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[Analysis of the prevalence status and clinical characteristics of the hepatitis D virus in the Xinjiang region]. [PDF]
Wang ZG +14 more
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用多聚酶链反应(PCR)技术检测了16例肝细胞性肝癌(HCC)患者癌灶和癌旁双份组织石蜡包埋标本中的乙型肝炎病毒脱氧核糖核酸(HBV-DNA)。以C基因引物扩增HBV-DNA,32份标本中检出率71.87%。以新鲜冷冻肝标本作对照检出率81.25%,二者相比无显著性差别(X~=0.57,P>0.05)。以质粒提取HBV-DNA作灵敏度测定,PCR-EB可达10fg,PCR-SBH可达lag。应用非放射性的地高辛素标记探针作杂交灵敏度达~32P标记探针的水平。
doaj
[Clinical research advances for small-molecule nucleic acid drugs in the treatment of chronic hepatitis B]. [PDF]
Wang WX +4 more
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丙型肝炎病毒核心抗原在HBV/HCV合并感染者血清中的检测状况及影响因素分析
【目的】 探讨丙型肝炎病毒核心抗原(HCVcAg)在乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)合并感染者血清中的检出状况,并分析其影响因素【方法】检测88例慢性丙型肝炎和62例HBV/HCV合并感染患者血清HCVcAg和HCV RNA,对后者血清进行HBV DNAHBeAg检测,分析HCVcAg检出率与HBeAgHBV DNA定量检测关系【结果】 88例慢性丙型肝炎和62例HBV/HCV合并感染者血清HCVcAg的检出率分别是72.7%(64/88)和38.7%(24/62),χ= 17.358,P
doaj
[Advances in basic and experimental diagnostic research on liver diseases in 2025]. [PDF]
Chen DB, Yang RF, Chen HS.
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[<i>Yiqi Jiedu</i> Formula regulates immune microenvironment of liver cancer in mice by inhibiting overactivation of NF-κB signaling pathway]. [PDF]
Wang Z +5 more
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[Introduction to the update points of the 2025 European Association for the Study of Liver clinical practice guidelines for the management of chronic hepatitis B infection]. [PDF]
Zhuang H.
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