Results 21 to 30 of about 882,341 (168)

PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma

open access: yesAdvanced Science, Volume 12, Issue 31, August 21, 2025.
CRISPR/Cas9 screening reveals PTPN2 as essential for ALK+ ALCL survival. PTPN2 regulates TFRC to promote PINK1‐PRKN mitophagy. Oral PTPN2 inhibitor ABBV‐CLS‐484 disrupts mitochondrial renewal and blocks TFRC‐mediated mitophagy to exert anti‐tumor activities, supporting clinical development for ALK+ ALCL.
Wei‐Ting Wang   +11 more
wiley   +1 more source

International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation

open access: yesDevelopmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019
目的 本国际临床指南由欧洲残疾儿童学会(the European Academy of Childhood Disability,EACD)牵头制定,旨在解决发育性协调障碍(developmental coordination disorder,DCD)的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题,通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础,以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类,最终转化为指南建议。并由国际 ...
Jing Hua   +6 more
wiley   +1 more source

论财务管理人才培养 [PDF]

open access: yes, 2004
由厦门大学会计发展研究中心提供的第四届会计与财务问题国际研讨会——会计教育改革与发展论文集中的第一部分:会计教育一般09财务管理人才培养需要高校和社会的共同努力。本文从财务管理人才的培养目标,素质要求,培养要求等方面,对财务管理人才培养的相关问题进行探讨,并对财务管理人员的管理及后续教育问题提出自己的看法,以引起社会各界对财务管理人才培养的重视 ...
王艳茹(中国青年政治学院经济系)
core  

Integrating sensor fusion with machine learning for comprehensive assessment of phenotypic traits and drought response in poplar species

open access: yesPlant Biotechnology Journal, Volume 23, Issue 7, Page 2464-2481, July 2025.
Summary Increased drought frequency and severity in a warming climate threaten the health and stability of forest ecosystems, influencing the structure and functioning of forests while having far‐reaching implications for global carbon storage and climate regulation.
Ziyang Zhou   +4 more
wiley   +1 more source

Optimization of training program of nursing undergraduate professional talents in research universities

open access: yesHuli yanjiu, 2015
为探讨研究型大学护理本科专业人才培养方案的完善和优化,通过比较国内外研究型大学护理本科专业人才培养方案,认为研究型大学现有的护理本科专业人才培养方案存在不足,一定程度上不利于高素质护理人才的培养。提出研究型大学护理本科专业的教学目标追求高层次、应用性和人文关怀,课程体系的构建体现专业化、实践性和人文性,教学和学习制度的建设倡导弹性化、个性化与自主性。
代桃莉
doaj  

Establishment and practice of Traditional Chinese Medicine Nursing Inheritance Studio (中医护理传承工作室的建立与实践)

open access: yes中西医结合护理, 2023
The establishment of the Traditional Chinese Medicine Nursing Inheritance Studio had enriched the training mode of Traditional Chinese Medicine nursing talents and promoted the innovation and promotion of Traditional Chinese medicine nursing technology ...
ZHAO Nan (赵楠)   +4 more
doaj   +1 more source

Discovery of Novel Pain Regulators Through Integration of Cross‐Species High‐Throughput Data

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.
Cross‐species analysis was used to identify novel pain mediators based on human DRG expression profiles and RNA‐seq data from a mouse model of neuropathic pain injury. ABSTRACT Aims Chronic pain is an impeding condition that affects day‐to‐day life and poses a substantial economic burden, surpassing many other health conditions.
Ying Chen   +9 more
wiley   +1 more source

对突破人才培养模式的若干思考 [PDF]

open access: yes, 2006
高校人才培养模式是教育观念、培养目标、培养规格和培养方式多层面有机结合的产物,涉及专业设置、课程设计、教学管理和质量控制等多个过程环节,其基本问题就是“培养什么样的人”和“怎么样培养人”。这两个基本问题已经被学术界讨论多年,从培养高级人才到培养创新人才的一系列大讨论中,人才培养模式的理论、政策和实践一直处在变革和充实之中 ...
史秋衡
core  

新形势下拔尖创新人才培养模式研究

open access: yes, 2022
拔尖创新人才是一个国家发展过程中,重要领域的领军人物或重要参与者,是推动国家科技进步,文明前进的重要力量。 本文主要站在中学教育的视角,对比分析研究“新加坡高才教育计划”和国内的清华、北大英才班、新领军人才项目以及中科大、西安交大等少年班、创新班等拔尖创新人才的选拔与培养方式及实施效果。学习新加坡高才教育的先进制度与教育理念。通过对比分析,找到我们的培养模式在拔尖创新人才的选拔、教学、心理健康建设、综合能力等方面的不足,深入研究这些问题的根源在哪里,从而提供拔尖创新人才培养机制有效运行的各种保障 ...
Liu, Yingcheng
core  

Demands for fostering of high nursing persons with ability in knowledge economy era

open access: yesHuli yanjiu, 2005
在知识经济时代 ,高等护理教育如何培养适应经济发展、社会进步的高等护理人才是护理教育工作者面临的一项重要课题。高等护理教育要抓住知识经济时代所带来的契机 ,更新教育理念 ,明确培养目标 ,改革旧的教育模式、课程设置、培养方法 ,从素质教育和培养创造性人才入手 ,实现教育的全面创新 ,培养现代化护理人才。
古宏文, 尤黎明
doaj  

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