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浙江大学学报. 医学版皮肤纤维化主要是指成纤维细胞过度增殖和细胞外基质过度沉积这一过程，会导致增生性瘢痕、瘢痕疙瘩、系统性硬化病等疾病。皮肤纤维化是一个动态变化的复杂过程，各种皮肤常驻细胞以及炎症细胞互相作用，最终导致细胞外基质沉积，甚至呈现侵袭性生长特征。细胞的表型及其功能的实现依赖于动态的细胞代谢反应，而细胞信号转导又与细胞代谢密切偶联。由于皮肤纤维化微环境中的细胞代谢-信号偶联对于炎症反应和纤维化活化至关重要，调节这些代谢途径可以为抑制甚至逆转皮肤纤维化进展的治疗提供新视角。本文系统回顾了皮肤纤维化中各类细胞的代谢特征，
钱 姝桐 +3 more
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Zhongguo shiyan zhenduanxue, 2013 系列"组学"技术的发展推动了基础研究水平的提高和深入。代谢组学作为一门新兴学科,着重研究的是生物整体、器官或组织的内源性代谢物质的代谢途径及其所受内在或外在因素影响下代谢整体的变化轨迹来反映某种病理生物过程。目前,代谢组学已广泛应用于生物学和医学相关的很多领域,在肝脏、心脏、肿瘤、肾脏等疾病中也有较深入的研究。本文就代谢组学的研究进展进行综述 ...
陆荣华, 杜玉君
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Zhongguo shiyan zhenduanxue抑郁症在全球范围内严重威胁着人类的身心健康，其发生发展与体内脂质和氨基酸等代谢异常有密切联系。犬尿氨酸及其下游代谢物如犬尿酸、3-羟基犬尿氨酸和犬尿喹啉酸等已证明影响抑郁症的发病过程，表明犬尿氨酸及其代谢物具有作为抑郁症诊断生物标志物的潜力。本文对抑郁症与犬尿氨酸及其代谢物之间的联系进行综述，可能为抑郁症的诊断与治疗提供新思路。
刘爱江, 李广泉, 崔然吉
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中西医结合护理, 2022 Objective To investigate the effect of multidisciplinary team management by using the PDCA approach in blood glucose control of elderly patients with type 2 diabetes in the non-endocrinology department.
FAN Meihong (樊美红) +1 more
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Progress of clinical observation and nursing of patients with pituitary apoplexy (垂体危象患者的临床观察与护理进展)
中西医结合护理, 2022 Given the complex of clinical classification in pituitary apoplexy, it is required to carry out detailed observation, timely treatment and comprehensive nursing for patients with pituitary apoplexy. This paper reviewed studies of clinical observation and
LIANG Qian (梁倩) +1 more
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Journal of Diabetes, Volume 15, Issue 12, Page 1070-1080, December 2023., 2023 Highlights Lipid profiles of small extracellular vesicles (sEVs) in patients with diabetes or diabetic cardiovascular disease are rarely reported. n‐3 docosahexaenoic acid (DHA)‐enriched triacylglycerol (TG) was found to decrease in sEVs from serum of patients with diabetic cardiovascular disease (DM‐CAD).
Wei Ding +3 more
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Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023 Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan +5 more
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Journal of Diabetes, Volume 15, Issue 11, Page 968-977, November 2023., 2023 Highlights Among 301 studies, diabetes mellitus was the most studied cardiometabolic risk factor. In the network meta‐analysis, cerebrovascular disease had the highest impact (relative risk [RR] 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors.
Alina Binbin Li +9 more
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Journal of Diabetes, Volume 15, Issue 11, Page 987-993, November 2023., 2023 Highlights We used data from the genome‐wide association studies database and two‐sample mendelian randomization method, we found that genetic evidence supporting that knee osteoarthritis is a potential risk factor for type 2 diabetes. Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D).
Xing Xing +3 more
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Journal of Diabetes, Volume 15, Issue 10, Page 900-910, October 2023., 2023 Highlights Mild acquired impaired thyroid hormone sensitivity was widespread among the general populations. Reduced thyroid hormone sensitivity was related with metabolic syndrome and its components. Impaired thyroid hormone sensitivity might affect the distribution of adipose tissue and muscle.
Fang Lv +6 more
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