Results 41 to 50 of about 20,882 (170)
Claw growth rates in a subset of adult, indoor, domestic cats (Felis catus)
Veterinary Dermatology, Volume 36, Issue 3, Page 362-367, June 2025.Background – Keratinised tissues, such as nails and claws, accumulate hormones over time; the claws' hormone concentrations are being explored as potential biomarkers. Timelines for hormone deposition can be established if claw growth rates are known. Hormone concentration within cat claws has been recently evaluated, yet the growth rates of cat claws ...
Elena T. Contreras +3 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2021 的身心健康[1]。充足的睡眠对正常的生长发育、代谢和免疫等至关重要。实验和流行病学研究均表明,睡眠时间和（或）质量的下降,尤其是阻塞性睡眠呼吸暂停（OSA）等睡眠障碍是心血管代谢异常的危险因素[2-4]。以胰岛素抵抗、高血脂、肥胖、冠心病等为主的心血管代谢性疾病患病率不断上升;而睡眠新近被认为是心血管代谢风险的预测因子[5]。本文综述了睡眠与心血管代谢性疾病的相关研究进展。1睡眠对糖代谢的影响睡眠不足和（或）睡眠障碍增加糖尿病发病风险。一项报告[6]称,0 ...
曾繁杰, 杨宝霞, 黎萍
doaj
The scale-up fermentation of DAM and preliminary study of DAM-induced apoptosis in HeLa cells [PDF]
, 2015 丰富的海洋生物资源为天然产物提供了重要来源，红树内生真菌由于独特的生理和代谢系统，产生了一些新颖独特的次级代谢产物。去乙酰真菌环氧二烯（Deacetylmycoepoxydiene，DAM）是本课题组杨丽珊同学从红树植物秋茄内生拟茎点霉属真菌A-1-2-3次级代谢产物中分离得到，具有新颖的含氧桥结构骨架，前期实验表明，该化合物具有较强的抗肿瘤活性。 本论文通过对菌株发酵技术参数的优化，确立了DAM液体发酵放大的工艺控制流程并进行了规模制备，初步阐明了DAM的抗肿瘤作用及其诱导HeLa细胞凋亡的作用机制 ...
林鹏
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Functional Ecology, Volume 39, Issue 5, Page 1274-1287, May 2025.Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between plants and soil microorganisms in the rhizosphere are vital for maintaining the nutrient cycle and stability of terrestrial ecosystems. Nitrogen, closely related to carbon (C) cycling and ecosystem productivity, undergoes transformation by soil ...
Ru Wang +9 more
wiley +1 more source
Structure and function research of the nuclear receptor PPARγ and its novel selective regulator [PDF]
, 2016 过氧化物酶体增殖剂激活受体家族(PPARs)是一类配体依赖型的激活因子，它们是核受体超家族中的重要成员。PPARs是机体调节新陈代谢平衡的关键转录因子，因此PPARs也成为了研发治疗糖尿病，心血管疾病等代谢相关疾病药物的热门分子靶标。 糖尿病是困扰现代人健康的一组常见代谢性疾病，但是目前临床上仍然缺乏安全且有效的糖尿病治疗药物。噻唑烷二酮（Thiazolidinedione，TZD)类药物是经典的PPARγ完全激动剂，由于它能够改善由糖尿病引起的胰岛素耐受等症状，目前已经运用于临床治疗Ⅱ型糖尿病 ...
邱琳
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Integrative Conservation, Volume 3, Issue 3, Page 168-182, September 2024.Using long‐term field data, we examined the impact of severe droughts on the health, reproductive success, and behavior of the critically endangered Verreaux's sifaka (Propithecus verreauxi) in Madagascar's seasonally dry tropical forest. Despite reduced availability of high‐quality foods, sifaka exhibited stable body condition and reproductive success,
Carrie C. Veilleux +2 more
wiley +1 more source
Zhongguo cuzhong zazhi代谢性脑血管病是一个新近提出的概念，指由传统代谢危险因素和残余代谢危险因素引起的脑血管损害，通过干预代谢危险因素可有效改善其预后的一种临床综合征。代谢途径并非独立存在，脑、心脏、肝脏、肾脏和肠道等多个器官的各种代谢途径相互影响、共同作用、交织成网，构成了人体的代谢网络，而代谢网络的异常导致了代谢性脑血管病的发生。同时，代谢危险因素的存在可同时造成多个靶器官损害，且神经系统与心血管系统、内分泌系统、消化系统等可通过多种病理生理过程相互影响。因此 ...
许杰, 王拥军 XU Jie, WANG Yongjun
doaj +1 more source
The relationship between the levels of white blood cell and lipopolysaccharide binding protein and intrahepatic triglyceride content , metabolic abnormalities in obese adults [PDF]
, 2016 研究目的 非酒精性脂肪性肝病（NAFLD）常常伴随炎性因子的增多，且其发生发展与代谢综合征和胰岛素抵抗紧密相关。本研究针对中心性肥胖人群进行横断面数据分析，探讨白细胞（WBC）及脂多糖结合蛋白水平（LBP）与肝脏脂质含量（IHTC）及其相关代谢异常的关系。 研究方法 本研究纳入485名40-65岁中心性肥胖受试者，进行问卷调查包括病史、生活方式等；测定生化指标并进行胰岛功能评估；通过氢质子磁共振波谱（1H-MRS）技术定量分析肝内甘油三酯含量；进行内脏脂肪含量等测定 ...
孙倩
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Integrative Conservation, Volume 3, Issue 3, Page 257-270, September 2024.Natural training enclosure design schematic. We selected 12 sika deer including six adults and six sub‐adults. Key considerations in the design of the natural training were to divide the training spatial ground into two parts (30 × 30 m small areas for isolation of new individuals and large areas measuring 200 × 600 m for free walking), and the ...
Wentao Zhang +10 more
wiley +1 more source
Study on the mechanism of FBXW7 protects against insulin resistance via regulating FetuinA protein level [PDF]
, 2016 目的：FBXW7属于SCF类泛素连接酶E3，可调控脂质代谢关键转录因子和胰岛功能相关蛋白的泛素化降解。FetuinA是一类参与机体糖脂代谢调控的重要肝脏因子，与胰岛素抵抗发生密切相关，但在肥胖状态下肝脏中蛋白水平异常升高机制不得而知。本研究拟探究FBXW7在肥胖状态下对FetuinA蛋白水平调节机制，有助于进一步完善肥胖致胰岛素抵抗机制。 方法：本课题结合高脂饮食诱导的HFD肥胖小鼠模型和正常饮食诱导的ob/ob小鼠肥胖模型，检测小鼠糖脂代谢相关指标，采用Real-timePCR和ELISA ...
刘祺
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