Results 11 to 20 of about 10,764 (168)

Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Improve Crohn’s Disease via Altered T Cell Differentiation [PDF]

, 2015
背景&目的：目前，有许多研究表明，无论是脂肪来源还是骨髓来源的的间充质干细胞都对克罗恩病和溃疡性结肠病实验室模型有益。甚至有些临床的一期实验，已经证明了间充质干细胞可以缓解炎症性肠病的临床症状和组织病理学损伤。然而，限制间充质干细胞临床研究与应用的最主要原因就是间充质干细胞在组织中的含量有限，很难得到充足的干细胞，满足临床研究和应用的需求，并且提取细胞的过程也会给病人或者细胞捐献者带来极大的痛苦。在此，我们的研究目的主要是探讨另一种新型来源的间充质干细胞即诱导多能干细胞来源的间充质干细胞（iPSC ...
芦方娜
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Providing regular and frequent maps of losses and gains of farmland birds based on European monitoring data

Conservation Biology, EarlyView.
Abstract Knowledge of species distributions is essential for informing policies on nature conservation and restoration. However, updating them on a regular basis and doing so in a harmonized manner at the international level is difficult. The European Bird Census Council integrated national monitoring data covering 5 years to update farmland bird ...
Sergi Herrando, Guillem Pocull, Sara Fraixedas, Anna Gamero, David Martí, Oriol Solà, Dani Villero, Verena Keller, Petr Voříšek, Alena Klvaňová, Gabriel Gargallo, Vitalie Ajder, Marc Anton, Ainars Aunins, Dawn Balmer, Mattia Brambilla, Tomasz Chodkiewicz, Przemysław Chylarecki, Cristi Domșa, Vlatka Dumbović Mazal, Virginia Escandell, Néstor Fernández, Ruud Foppen, Juan Gallego‐Zamorano, Carlos Godinho, Irene Guerrero, Christina Ieronymidou, Frédéric Jiguet, Aleksi Lehikoinen, Primož Kmecl, Peter Knaus, Lechosław Kuczyński, Åke Lindström, Qenan Maxhuni, Blas Molina, Jean‐Yves Paquet, Maria Luisa Paracchini, Danae Portolou, Draženko Z. Rajković, Dimitrije Radišić, Jiří Reif, Paul Shimmings, Henk Sierdsema, Jovica Sjeničić, Karel Šťastný, Bård G. Stokke, Nicolas Strebel, Zoltán D. Szabó, Tibor Szép, Norbert Teufelbauer, Nicolas Titeux, Sven Trautmann, Judit Veres‐Szászkac, Thomas Vikstrøm, Lluís Brotons   +54 more
wiley   +1 more source

Amniotic membrane with live stromal cells facilitates preservation and expansion of corneal epithelial stem cells [PDF]

, 2012
角膜上皮干细胞存在于角膜缘基底部，严重眼表面疾病常导致角膜上皮干细胞缺乏，造成患者严重视功能障碍甚至失明。角膜上皮干细胞体外扩增和移植是目前治疗严重角膜上皮干细胞缺乏的有效方法。理想的角膜上皮干细胞体外扩增技术是在体外模拟角膜上皮干细胞所处的微环境，以保持干细胞的特性并促进干细胞的增殖。迄今已有不同技术用于体外扩增角膜上皮干细胞，包括采用不同的载体，经过不同处理的供体细胞，以及不同的培养基等。到目前为止还没有建立一个标准化的角膜上皮干细胞体外扩增技术。 目的：羊膜作为一种载体 ...
杨洁
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Bimetallic NiCo Loaded on the Nitrogen‐Rich Modified Lignin‐Derived Carbon Coordination Network for Accelerated Oxygen Reduction Kinetics

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT The development of novel oxygen electrocatalysts with cost‐effectiveness, scalability, high catalytic activity, and stability presents a significant challenge for zinc–air batteries (ZABs). The nitrogen‐rich lignin coordination network structure is synthesized through amine modification of lignin.
Ping‐Xian Feng, Xuan‐Zhen Zhang, Hui Luo, Zhi‐Yi Huang, Ya‐Ru Luo, Yun‐Hui Feng, Wei Liu, Guo‐Bin Yi, Huan Wang   +8 more
wiley   +1 more source

The Expression and Biological Significance of PD-L1 on Lung Cancer Cell Lines [PDF]

, 2009
Background and objective Tumor-associated PD-L1 expression was recently shown to promote T-cell apoptosis and proposed as a potential mechanism of immune evasion by tumors. On the basis of the ability of tumor-associated PD-L1 to mediate activated T-cell
Cheng CHEN, Chuanyong MU, Jian’an HUANG, Jing SUN, Qiuxia QU, Xueguang ZHANG, Yibei ZHU   +6 more
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Using miniaturized laboratory equipment and DNA barcoding to improve conservation genetics training and identify illegally traded species

Conservation Biology, Volume 40, Issue 2, April 2026.
Abstract Illegal wildlife trade (IWT) is one of the largest global illegal activities, and it negatively affects biodiversity and sustainable development worldwide. DNA barcoding coupled with high‐throughput sequencing (i.e., metabarcoding) is useful in identifying taxa affected by IWT and has been used routinely for decades.
Maria Joana Ferreira da Silva, Ivo Colmonero‐Costeira, Saidil Lamine Djaló, Tomás Camará, Rui M. Sá, Tania Minhós, Angelika Kiebler, Martin Grethlein, Netta Pikkarainen, Stefan Prost   +9 more
wiley   +1 more source

Screening and application of aptamers to Staphylococcus aureus Toxic Shock Syndrome Toxin-1 [PDF]

, 2016
摘要 目的：金黄色葡萄球菌(Staphylococcusaureus)分泌的毒性休克综合征毒素-1(ToxicShockSyndromeToxin-1，TSST-1)引发中毒性休克综合征(ToxicShockSyndrome，TSS)，通过激活T淋巴细胞使其活化、增殖，引起强烈的免疫应答。目前针对TSST-1本身的治疗手段不多，合成寡核苷酸文库和亲和力筛选作为获得高亲和力、高特异性适配体(Aptamer)的一种方便、快捷、有效的方法。本研究利用指数富集的配体系统进化技术 ...
陈弘炜
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In vitro culture, cryopreservation, and field reintroduction of the endangered Mingan thistle

Conservation Biology, Volume 40, Issue 2, April 2026.
Abstract Current plant conservation efforts are hindered by, for example, poor seed germination, low viability, and insufficient propagation and preservation technologies. To address these problems, we devised an approach to plant conservation that integrates conservation, preservation, and restoration (CPR), which uses advanced in vitro techniques. We
Mukund R. Shukla, Wenlu Bi, Marie‐Claude Roy, Dénommée Nancy, Praveen K. Saxena   +4 more
wiley   +1 more source

Ex vivo expansion and differentiation of rat Meibomian gland progenitor cells [PDF]

, 2017
目的：睑板腺功能障碍（Meibomianglanddysfunction，MGD）尚无有效的药物治疗方法，通过优化大鼠睑板腺祖细胞（ProgenitorcellsofMeibomiangland）的培养方法，研究睑板腺祖细胞体外克隆培养、扩增、分化的特点及表型，可提供一种有效的体外药物筛选工具。 方法：从8周龄大鼠的眼睑中分离出睑板腺，通过酶消化法将其消化成为睑板腺单个细胞，与丝裂霉素处理过的3T3-L1细胞混合均匀后接种，用含激素的上皮培养基 ...
左程友
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Impacts of Human Development on Wildlife Use of Corridors in Botswana 人类开发对博茨瓦纳野生动物廊道利用的影响

Integrative Conservation, Volume 5, Issue 1, Page 164-171, March 2026.
This study examined the effect of landscape‐scale human impact on wildlife in Botswana. We examined how species use wildlife corridors in two different human‐dominated landscapes. We identified differences in temporal overlap between wildlife and humans across both landscapes, which is fundamental to consider in both current and future conservation ...
Tempe S. F. Adams, Keith Leggett, Michael J. Chase, Marlee A. Tucker   +3 more
wiley   +1 more source