Results 11 to 20 of about 9,570 (165)

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

open access: yesJournal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang   +6 more
wiley   +1 more source

The influence of posttraumatic stress disorder treatment on anxiety sensitivity: Impact of prolonged exposure, sertraline, and their combination

open access: yesJournal of Traumatic Stress, Volume 36, Issue 1, Page 157-166, February 2023., 2023
Abstract Trauma‐informed beliefs often decrease during posttraumatic stress disorder (PTSD) treatment. This may also extend to anxiety sensitivity (AS), defined as a fear of anxiety‐related sensations and beliefs that anxiety is dangerous and/or intolerable.
Matthew T. Luciano   +11 more
wiley   +1 more source

Exploring metapopulation‐scale suppression alternatives for a global invader in a river network experiencing climate change

open access: yesConservation Biology, Volume 37, Issue 1, February 2023., 2023
Abstract Invasive species can dramatically alter ecosystems, but eradication is difficult, and suppression is expensive once they are established. Uncertainties in the potential for expansion and impacts by an invader can lead to delayed and inadequate suppression, allowing for establishment.
Brian D. Healy   +5 more
wiley   +1 more source

Effect of an ear cleaner instillation containing lipacids in a model of re‐acidification of the external auditory canal in dogs

open access: yesVeterinary Dermatology, Volume 33, Issue 5, Page 402-406, October 2022., 2022
Abstract Background In humans, the acidic pH of the ear canal plays a protective role against infection and a change towards alkalinity of the external auditory canal (EAC) is a local factor in the progression of acute to chronic otitis externa (OE).
Pauline Panzuti   +5 more
wiley   +1 more source

The effect of a mixed cannabidiol and cannabidiolic acid based oil on client‐owned dogs with atopic dermatitis

open access: yesVeterinary Dermatology, Volume 33, Issue 4, Page 329-e77, August 2022., 2022
Background– Cannabidiol (CBD) and cannabidiolic acid (CBDA) are reported to have antinociceptive, immunomodulatory and anti‐inflammatory actions. Objectives – To determine if CBD/CBDA is an effective therapy for canine atopic dermatitis (cAD). Conclusions and clinical relevance – Cannabidiol/CBDA as an adjunct therapy decreased pruritus, and not skin ...
Melissa Loewinger   +4 more
wiley   +1 more source

Health utilities in Chinese patients with coronary heart disease and impaired glucose tolerance (ACE): A longitudinal analysis of a randomized, double‐blind, placebo‐controlled trial 中国冠心病合并糖耐量异常患者的健康相关生活质量:一项随机、双盲、安慰剂对照试验的纵向分析

open access: yesJournal of Diabetes, Volume 14, Issue 7, Page 455-464, July 2022., 2022
Highlights The Acarbose Cardiovascular Evaluation (ACE) trial assessed the effects of acarbose in patients with coronary heart disease (CHD) and impaired glucose tolerance (IGT) in China. Acarbose treatment did not impact on health‐related quality of life in ACE trial participants with CHD and IGT. Myocardial infarction (MI), stroke, heart failure, and
José Leal   +4 more
wiley   +1 more source

Plant diversity ameliorates the evolutionary development of fungicide resistance in an agricultural ecosystem

open access: yesJournal of Applied Ecology, Volume 58, Issue 11, Page 2566-2578, November 2021., 2021
The development of fungicide resistance greatly threatens food security and ecological sustainability, and it is urgent need to develop agricultural practices which can ameliorate this problem. Our results show that potato crop with a genetic diversity is associated with a late blight pathogen of higher fungicide sensitivity and lower potential of ...
Li‐Na Yang   +8 more
wiley   +1 more source

A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client‐owned dogs with allergic dermatitis

open access: yesVeterinary Dermatology, Volume 32, Issue 5, Page 477-e131, October 2021., 2021
Background – Interleukin (IL)‐31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases. Hypothesis/Objectives – To demonstrate the efficacy and safety of lokivetmab (canine anti‐IL‐31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.
Leen Van Brussel   +4 more
wiley   +1 more source

Construction and Mechanism of Action of Gelatin/Sodium Hexametaphosphate/Glutamine Aminotransferase Based Composite Hydrogel System [PDF]

open access: yes, 2023
In this study, a composite hydrogel system was constructed by cross-linking of primary network hydrogels of gelatin (GE) and sodium hexametaphosphate (SHMP) by transglutaminase (TGase) after addition of Lactobacillus plantarum in order to improve its ...
LIU Zhiqin, CHEN Junliang, REN Guangyue, DUAN Xu, CAO Weiwei, LI Linlin, ZHAO Mengyue, JIN Xin
core   +1 more source

连续失水-复水中不同粒径保水剂对土壤结构和水分特性的影响

open access: yesShuitu Baochi Xuebao, 2021
为明确土壤干湿交替环境下保水剂与土壤颗粒之间的作用方式及保水剂对土壤结构和水分有效性的影响。通过土柱模拟试验,研究连续失水—复水条件下,不同粒径(>0.85,0.6~0.85,0.30~0.45 mm)保水剂对土壤水分特性、土壤团聚体分布和结构稳定性的作用,以及保水剂—土壤混合体价键结构的微观变化特征。结果表明:第1次(T1)和第2次(T2)失水取样阶段,除T2阶段的最小粒径处理外,其余各粒径保水剂促使土壤相对含水量较对照显著增加72.9%以上 ...
纪冰祎   +5 more
doaj  

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