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脂噬是一种新型的脂质代谢,是细胞内脂滴选择性自噬降解的过程。脂噬与脂代谢相互作用,对维持机体能量平衡至关重要。生长因子、能量等多种信号参与了mTOR信号通路的调控并对脂噬产生影响。大量研究表明mTOR通路介导的脂噬对多种疾病的发生和发展起关键作用。本文综述了mTOR信号通路介导的脂噬在肝脏疾病、病毒感染疾病及神经系统疾病的调控机制,靶向脂噬可能成为未来治疗多种疾病的新策略。
吴璟玥, 包晓丹, 乔璐, 包丽丽
doaj
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[Overexpression of lncRNA SNHG12 promotes docetaxel resistance of prostate cancer cells by activating PI3K/AKT signaling <i>via</i> interacting with ELAVL1]. [PDF]
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