Results 31 to 40 of about 11,366 (167)
Long‐term use of lokivetmab in dogs with atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 6, Page 683-693, December 2024.Background – Lokivetmab, a caninised monoclonal antibody against interleukin (IL)‐31, is an effective treatment for the pruritus associated with canine atopic dermatitis (cAD). Objectives – To investigate the efficacy and safety of lokivetmab during long‐term treatment defined as at least three consecutive lokivetmab injections in atopic dogs under ...
Bettina Kasper +2 more
wiley +1 more source
A Novel Method for Detecting p53 Autoantibodies in Sera of Patients with NSCLC [PDF]
, 2009 Background and objective Serum autoantibody detection is useful means for the early diagnosis and prognosis of cancer. So our objective was to synthesize peptide array to analyse p53 autoantibodies in the sera of patients with non small cell lung cancer (
Kai TANG +4 more
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A multicentric intermediate‐size B‐cell lymphoma with epitheliotropism in a Freiberger mare
Veterinary Dermatology, Volume 35, Issue 5, Page 573-577, October 2024.This report describes a multicentric intermediate‐size B‐cell lymphoma with epitheliotropism in a Freiberger mare affecting multiple mucous membranes, skin and internal organs. The clonal neoplastic B‐cell population was accompanied by numerous reactive polyclonal small T cells. Differential diagnoses for these unusual findings are discussed.
Inês Berenguer Veiga +6 more
wiley +1 more source
Construction and preliminary application of human naïve phage antibody library [PDF]
, 2004 治疗性抗体在临床的应用已从30年代的抗血清时代经由80年代后的单克隆抗体时代进入到今天的基因工程抗体时代。目前处于各期临床的生物新药中，基因工程抗体是最多的一类，显示出治疗性抗体具有广阔的临床应用前景，而人源抗体是治疗性抗体的发展趋势。人源性噬菌体抗体库技术解决了人源性单抗来源困难、人体杂交瘤系统低效及鼠单抗的动物源性难题，是分子生物学和免疫学领域中一个强有力的研究手段。本研究从20例未经免疫的健康人的外周血中分离出淋巴细胞，提取总RNA并纯化出mRNA，然后反转录成cDNA ...
李利峰
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Ultrasound in Obstetrics &Gynecology, Volume 63, Issue 2, Page 263-270, February 2024.ABSTRACT Objective To determine the diagnostic test accuracy of transvaginal ultrasound (TVS) using a standardized technique for the diagnosis of deep endometriosis (DE) of the uterosacral ligaments (USLs) and adjacent torus uterinus (TU). Methods This was a prospective diagnostic test accuracy study conducted at the McMaster University Medical Center ...
S. M. Freger +3 more
wiley +1 more source
The establishment of arsenite-transformed cells (TLECs) and the study on methylation of non-CpG island promoter repressing NQO1 expression in TLECs [PDF]
, 2016 摘 要 砷及其衍生物广泛分布自然环境并对人类健康构成危害。虽然流行病学研究已经证实长期的砷暴露能诱发多种癌症，但对砷致癌的确切机制目前远未被阐明，需要进一步深入地探索。砷诱导肿瘤形成是一个长期和复杂的过程，相关研究工作首先需要一个合适的细胞模型。为此，我们以低浓度亚砷酸钠长时间处理正常的大鼠肺上皮细胞系（LECs）诱导其转化，再通过一系列的指标实验验证，成功地建立砷转化细胞模型TLECs（Arsenite-transformedLECs），从而为下一步的研究奠定基础 ...
黄宁宇
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, 2012 中国水产养殖的成就已被认为是中国对当今世界发展的一个重大贡献.近20年来,基因组学和其他遗传技术的进步显著推动着水产动物分子生物学和遗传育种学基础研究的发展.进入21世纪后,一些主要水产动物的全基因组测序已经完成或接近完成.本文综述了包括基因组技术、体细胞核移植和干细胞技术在内的水产遗传改良技术的一些重要突破性进展,概述了包括生殖、性别、生长、抗病、耐寒和耐低氧这些重要经济性状的分子基础,列出了一系列与这些经济性状相关的候选基因.最后,介绍了几个特别是中国水产动物遗传改良在水产养殖中的应用事例 ...
朱作言, 桂建芳
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Cloning and Stress Response of the Cold-Regulated Genes of Adenine Nucleotide Translocase 2, the Chaperonin Containing Tailless Complex Polypeptide α and Stearoyl-CoA Desaturase in the Mud Crab, Scylla paramamosain [PDF]
, 2015 腺苷酸转移酶(adeninenucleotidetranslocase,ANT)，属于线粒体转运蛋白超家族，是线粒体中最丰富的蛋白质之一，主要作用是介导ADP/ATP在细胞质和线粒体基质之间的运输。伴侣素包含T型复合体(thechaperonincontainingtaillesscomplexpolypeptideα,CCTα)是几乎存在所有生物体中的一类分子伴侣，负责细胞内蛋白的组装和折叠。内质网内的硬脂酰去饱和酶(stearoyl-CoAdesaturase,SCD)，是一类含铁离子的限速酶 ...
于坤
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赤点石斑鱼促甲状腺激素TSHβ启动子的克隆及其在斑马鱼胚胎原始性腺和垂体中定位表达 [PDF]
, 2010 促甲状腺激素(Thyroid-stimulating hormone,TSH)具有调节生长,发育,代谢和生殖的功能,但是在低等脊椎动物中的功能研究较少。斜带石斑鱼(Epinephelus coioides)促甲状腺激素TSHβ除在垂体中表达外还在性腺中表达,进一步发现TSHβ也在赤点石斑鱼(Epinephelus akaara)性腺中表达。且在人工诱导的赤点石斑鱼中,随着雄性化的转变,TSHβ转录水平升高。为研究石斑鱼TSHβ特殊表达方式的调控机制,采用基因组步移技术扩增获得赤点石斑鱼TSHβ5 ...
周莉, 李辰昱, 桂建芳, 汪洋
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乌鳢免疫球蛋白M重链和免疫球蛋白轻链的克隆与特征分析 [PDF]
, 2010 应用RACE-PCR方法克隆并鉴定了乌鳢免疫球蛋白M(i mmunoglobulin M,Ig M)重链(H)和免疫球蛋白轻链(L)全长cDNA。乌鳢IgH cDNA全长1 912个核苷酸(nt),包含1 797 nt的开放阅读框,编码598个氨基酸(aa)。IgH恒定区(CH)均包含1对保守的半胱氨酸残基形成链内二硫键,其中CH1区氨基末端存在保守的半胱氨酸残基与轻链形成链间二硫键,4个推测的N-糖基化位点(NXT和NXS)则分别位于CH1、CH2和CH4 ...
周秀霞, 贾伟章
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