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野生动物学报, 2012 多年来动物园虽然严格按照国家强制要求对园内饲养的野生鸟类进行禽流感疫苗的免疫接种工作,但是对于接种后各种鸟类免疫效果的问题仍未有研究。本次研究主要目的为探究圈养鸟类免疫商品化禽流感疫苗后的免疫效果如何,以及各个物种对疫苗的免疫应答水平是否相同。实验中选取动物园几种圈养小型鹦鹉科鸟类为实验对象,对其进行禽流感H5N1亚型疫苗免疫接种后,利用血凝（HA）及血凝抑制（HI）实验监测禽流感抗体水平变化规律,评估免疫效果。从初步的实验结果发现,鹦鹉科鸟类仅接种一次商品化禽流感疫苗,其免疫应答水平普遍偏低 ...
李莹, 吴秀山, 张成林, 张金国
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野生动物学报, 2013 为研究动物园圈养野生禽类高致病性禽流感疫苗免疫后的抗体水平,本文以雉鸡、缅甸鹦鹉、原鸡、蓝孔雀、白鸽为研究对象,接种H5亚型禽流感灭活油乳剂疫苗,利用禽流感血凝及血凝抑制试验,分别在首免日、免疫后21 d、30 d、60 d、120 d和180 d监测禽流感免疫抗体变化。结果表明5组禽类均在疫苗接种后产生禽流感抗体,当30 d加强免疫后,第60 d抗体达到峰值,120 d后抗体开始下降。通过研究,证实商品化疫苗对动物园圈养野生禽类有效,同时提出圈养野生禽类的高致病性禽流感免疫程序 ...
马萍 +6 more
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The safety of rush immunotherapy in the management of canine atopic dermatitis—230 cases
Veterinary Dermatology, Volume 34, Issue 5, Page 385-392, October 2023., 2023 Background – The duration of the induction phase of allergen‐specific immunotherapy conventionally is a period of several weeks, during which the volume of an allergen solution, administered by injection, is gradually increased until the maintenance dose is reached.
Tamara Weitzer, Ralf Mueller
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Journal of Advanced Nursing, Volume 76, Issue 8, Page 2191-2197, August 2020., 2020 Abstract Aim To determine the effectiveness of a hydrophobic dressing (Cutimed Sorbact®) against a silver dressing (Aquacel® Ag Extra) in the level of colonization of chronic venous leg ulcers. The secondary endpoints are health‐related quality of life, level of pain, and time to complete healing.
Juan C. Morilla‐Herrera +9 more
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Current Status of PD-1/PD-L1 Anti-tumor Therapy and Exploration of the Mechanism of Immune-related Adverse Events [PDF]
, 2022 Programmed cell death protein-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors are a group of immune checkpoint inhibitors. Since May 2006, there have been 10 immune checkpoint inhibitors targeting PD-1 and PD-L1 for tumor treatment. Although PD-
YANG Leiyi, LIN Sang, XIE Qibing, YIN Geng
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Epidemiological Analysis of 7 280 Rabies Exposure Cases in a Hospital [PDF]
, 2017 目的 分析某院2014—2016年狂犬病暴露患者的流行病学特征及暴露后处置情况,为加强本市城乡结合地区狂犬病防治工作提供科学依据。方法 根据医院HIS系统的资料,对伤人动物类别及就诊患者的性别、年龄、暴露级别、就诊时间、疫苗接种情况等相关因素进行统计分析。结果 2014—2016年某院共有7 280例患者接种了狂犬病疫苗,其中被犬咬（抓）伤者占87.18%;青年期和中年期两个年龄段的构成比占了62.34%。不同月份被动物咬（抓）伤者构成比比较,差异有统计学意义（P〈0.05）。狂犬病疫苗接种率为100 ...
杨丽雄, 蔡丽秋
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The Oncologist, Volume 24, Issue 11, Page e1055-e1069, November 2019., 2019 Abstract In the light of recent advances in the immunotherapy field for breast cancer (BC) treatment, especially in the triple‐negative subtype, the identification of reliable biomarkers capable of improving patient selection is paramount, because only a portion of patients seem to derive benefit from this appealing treatment strategy. In this context,
Federica Miglietta +3 more
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Preparation and Application of Soluble Human Squamous Cell Carcinoma Antigen Expressed by Escherichia coli [PDF]
, 2017 旨在建立基于大肠杆菌表达系统的高效可溶性表达人鳞状上皮细胞癌抗原(SCCAg)方法,获得具有较好活性的重组SCCAg抗原并应用于建立抗原检测方法; 。基于pGEX-6P-l载体和大肠杆菌E. coli; ER2566菌株开展重组SCCAg抗原可溶性表达纯化方法研究,评价纯化抗原活性,筛选特异性单克隆抗体,初步建立并评价SCCAg抗原检测方法。结果; 显示,pGEX-6P-l载体和E coli; ER2566菌株可用于建立较高效的可溶性表达和纯化SCCAg抗原的方法 ...
刘剑 +9 more
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Zhejiang Daxue xuebao. Lixue ban, 2005 构建ltB-ureB融合基因原核表达系统并对其表达产物的免疫性和佐剂活性进行鉴定.采用PCR和T-A克隆法从幽门螺杆菌(Helicobacter pylori,Hp）临床菌株Y06和大肠杆菌44851株DNA中获得了ureB和ltB全长基因扩增片段及其克隆，并构建了ltB-ureB融合基因及其原核表达系统pET32a-ltB-ureB-E. coli BL21DE3.在E.
WANGYuan(王媛), YANJie(严杰)
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Zhongguo shiyan zhenduanxue, 2020 近年来出现的免疫检查点抑制剂,彻底颠覆了癌症的诊断及治疗策略。免疫检查点抑制剂通过阻断免疫内在的负性因子如细胞毒性T淋巴细胞相关抗原4 (cytotoxic T lymphocyte-associated antigen 4,CTLA-4),程序性死亡受体-1(programmed death receptor-1,PD-1)/程序性死亡配体-1(pro-
陈康, 孙步彤
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