Results 11 to 20 of about 1,047,800 (166)

免疫组化方法在检测肾淀粉样变中的应用

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2014
摘 要: 【目的】 探讨应用甲基紫染色?刚果红染色和免疫组化3种方法检测38例不同类型的肾淀粉样变的效果? 【方法】 将38例肾标本常规处理后,分别用甲基紫?刚果红染色和免疫组化3种方法进行检测,统计检测结果并分析?【结果】 甲基紫染色能够准确检测肾淀粉样变,但不能进行分型,且需及时观察;刚果红染色能够准确检测肾淀粉样变,联合氧化后的刚果红染色能够区分AA型与AL型淀粉样变;免疫组化检测能够准确检测肾淀粉样变,并对其进行分型,AA型SAA蛋白阳性,AL型kappa和lambda蛋白阳性?【结论 ...
doaj   +1 more source

SARS‐CoV‐2 infection as cause of in‐utero fetal death: regional multicenter cohort study

open access: yesUltrasound in Obstetrics &Gynecology, Volume 62, Issue 6, Page 867-874, December 2023., 2023
ABSTRACT Objective Placental infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can lead to placental insufficiency and in‐utero fetal death (IUFD). The objective of this study was to confirm and quantify the extent to which fetoplacental infection with SARS‐CoV‐2 is a cause of fetal death.
M. Nkobetchou   +9 more
wiley   +1 more source

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

open access: yesJournal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang   +6 more
wiley   +1 more source

Successful surgical removal of a pheochromocytoma in a mare via trans‐costal approach

open access: yesEquine Veterinary Journal, Volume 55, Issue 6, Page 1012-1020, November 2023., 2023
Abstract Background Pheochromocytomas have been previously reported in horses, but successful antemortem diagnosis and surgical removal without recurrence of clinical signs have not been described. Objective To report the clinical presentation, diagnostic evaluation, surgical technique, anaesthetic management and post‐operative care of a mare diagnosed
Thomas J. O'Brien   +6 more
wiley   +1 more source

Glycosylated fibronectin improves first‐trimester prediction of pre‐eclampsia

open access: yesUltrasound in Obstetrics &Gynecology, Volume 62, Issue 4, Page 512-521, October 2023., 2023
ABSTRACT Objective To determine whether maternal serum glycosylated fibronectin (GlyFn) level in the first trimester increases the sensitivity of the Fetal Medicine Foundation (FMF) triple test, which incorporates mean arterial pressure, uterine artery pulsatility index and placental growth factor, when screening for pre‐eclampsia (PE) in an Asian ...
S. Moungmaithong   +7 more
wiley   +1 more source

Histopathological characterisation of trunk‐dominant canine pemphigus foliaceus, and comparison with classic facial and insecticide‐triggered forms

open access: yesVeterinary Dermatology, Volume 34, Issue 5, Page 425-440, October 2023., 2023
Background – While the clinical features were described recently, the histopathological characterisation of trunk‐dominant canine pemphigus foliaceus (PF) is lacking, and whether it differs from classic facial or insecticide‐triggered PF is unknown. Hypothesis/Objectives – This study describes the histopathological findings of trunk‐dominant PF, and ...
Natalie Katharina Yvonne Gedon   +6 more
wiley   +1 more source

Association between follicle‐stimulating hormone and nonalcoholic fatty liver disease in postmenopausal women with type 2 diabetes mellitus 绝经后2型糖尿病女性中卵泡刺激素与非酒精性脂肪性肝病的相关性

open access: yesJournal of Diabetes, Volume 15, Issue 8, Page 640-648, August 2023., 2023
Highlights In Chinese postmenopausal women with type 2 diabetes mellitus, serum follicle‐stimulating hormone levels were negatively and independently associated with the prevalence of nonalcoholic fatty liver disease. Metabolic conditions, including overweight/obesity, central obesity, hyperuricemia, hypertension, and dyslipidemia did not interact with
Shengjie Ge   +10 more
wiley   +1 more source

エネルギー代謝を介したT細胞分化と長期免疫の誘導

open access: yes, 2021
T細胞は,抗原提示を受けた後に活性化および増殖し,その多くはエフェクターT細胞へと分化して様々な病原体や腫瘍細胞の排除に働くが,寿命が短く,その大半は短期間で死滅してしまう。一方,一部のT細胞は,メモリーT細胞へと分化して長期間体内で維持され,再び同じ抗原に出会うと,初回よりも強い免疫が誘導される。この現象は,ワクチン有効性の原理ともなっているが,このようなT細胞分化がどのように制御されているか不明な点も多く,現在の免疫学における重要な研究課題となっている。近年の研究から ...
田野, ゆづき   +11 more
core   +1 more source

Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy

open access: yesRare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang   +6 more
wiley   +1 more source

Titanium Implant Abutments With Polydopamine‐Mesoporous Cerium Dioxide Coatings for Enhanced Antibacterial, Anti‐Inflammatory, and Soft Tissue Integration Properties

open access: yesRare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT The poor soft tissue integration around titanium implants creates a microgap that serves as a pathway for pathogen invasion, resulting in infection, inflammation, and the progression of peri‐implantitis. As the implant’s transmucosal component, the abutment determines the degree of peri‐implant soft tissue attachment.
Xuan Li   +7 more
wiley   +1 more source

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