Results 21 to 30 of about 1,047,800 (166)
Biomimetic Metallopeptidases for Biomedical Applications: From Modular Design to Disease Treatment
Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT Biomimetic metallopeptidases, as an emerging class of artificial enzyme systems, have demonstrated tremendous application potential in the biomedical field in recent years. Their core design principle is to rationally control amino acid composition and three‐dimensional conformation so that programmable peptide sequences can efficiently ...
Ke Ma, Ke‐Zheng Chen, Sheng‐Lin Qiao
wiley +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 4, Page 455-460, April 2026.ABSTRACT Objective To estimate the residual risk of maternal–fetal transmission after primary cytomegalovirus (CMV) infection in the periconceptional period or the first trimester in women treated with valacyclovir, and to assess whether the presence of glycoprotein B2 (gB2)‐specific immunoglobulin (Ig)‐G antibodies on immunoblot analysis refines fetal
K. O. Kagan +6 more
wiley +1 more source
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的探讨胃肠道间质瘤（gastrointestinal stromal tumor,GIST）的临床病理、免疫组化特点。方法观察67例胃肠道间质瘤形态学特征及免疫组化染色。结果61.2%胃肠道间质瘤发生在小肠,瘤细胞为梭形或上皮样,或两者混合存在,胞浆嗜酸性较弱,免疫组化表型为CD34+,CD117+。结论胃肠道间质瘤有较独特的免疫组化表型,免疫组化可协助鉴别诊断。
李潮, 宋丁
doaj
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2019 目的探讨乳腺癌中精确计算Ki-67增殖指数的方法。方法应用Ki-67与CK（广）免疫组化双重染色法与免疫组化单染法进行对比。结果乳腺癌细胞免疫组化双重染色结构清晰,易于观察,与常规免疫组化染色相比,Ki-67比值"1+"增高,"3+"减少,经χ2检验具有统计学意义。结论免疫组化双重染色法对于Ki-67比值的判断优于单染法,为乳腺癌预后评估和指导辅助治疗的选择提供依据。
李悦, 于秀文
doaj
First report of indolent cutaneous T‐cell lymphoma in a fennec fox (Vulpes zerda)
Veterinary Dermatology, Volume 36, Issue 5, Page 707-711, October 2025.A 10‐year‐old fennec fox (Vulpes zerda) was presented for multifocal regions of chronic alopecia and crusting. Cutaneous lymphocytosis was diagnosed through histopathological examination and immunohistochemical investigation. Clonal rearrangement of the T‐cell receptor gamma locus supports that lymphocytosis in this case is an indolent lymphoma ...
Kristen L. Shekelle +5 more
wiley +1 more source
CD40、HLA-DR在自身免疫性肝病Kupffer细胞的表达变化
Zhongguo shiyan zhenduanxue, 2017 目的研究自身免疫性肝病Kupffer细胞抗原呈递分子的表达变化。方法按照自身免疫性肝炎、原发性胆汁性胆管炎的诊断标准进行分组,脂肪肝作为对照组。入选患者的肝穿石蜡切片进行CD40、HLA-DR免疫组化染色,随机选取10个显微镜高倍视野（×400倍）,观察染色情况,并统计CD40+、HLA-DR+细胞数目。结果20CD40在自身免疫性肝病组的阳性细胞数低于对照组。CD40免疫组化阳性产物呈棕褐色或棕黄色颗粒状着色,主要位于细胞膜,少部分位于细胞质。分别计算自身免疫性肝炎 ...
李虹霞, 郭丽萍, 张君, 周璐
doaj
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
, 1990 应用6种抗体(CEA、MAK-6、EMA、S-100、GFAP、HHF-35)对55例涎腺肿瘤和9例肿瘤旁涎腺组织进行免疫组化研究,结果表明:肿瘤旁涎腺组织的免疫光谱,以腺管上皮细胞为一端,肌上皮细胞为另一端,润管细胞和腺泡细胞位于光谱中间段,多形性腺瘤起源于同一类细胞,而不是混合性起源。简略介绍HHF-35的性质和应用价值,在识别肌上皮细胞方面,HHF ...
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