Results 21 to 30 of about 13,244 (215)

Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells 2型糖尿病、细胞功能障碍和氧化还原信号的关系:人胰腺α‐和β‐细胞单细胞基因表达的meta分析

Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022
Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques, Emily Formato, Wenle Liang, Emily Leonard, Alicia R. Timme‐Laragy   +4 more
wiley   +1 more source

Immune‐checkpoint inhibitor‐associated diabetes compared to other diabetes types ‐ A prospective, matched control study 免疫检查点抑制剂相关糖尿病与其他糖尿病类型的比较‐‐一项前瞻性配对对照研究

Journal of Diabetes, Volume 13, Issue 12, Page 1007-1014, December 2021., 2021
Highlights This prospective study compares 15 patients with immune‐checkpoint induced diabetes mellitus (CPI‐DM) with a propensity score matched cohort of patients with other diabetes types. Diabetic ketoacidosis at onset and autoimmune comorbidity is more frequent in CPI‐DM patients. This can be avoided by regular glucose measurements and education on
Sascha R. Tittel, Katharina Laubner, Sebastian M. Schmid, Stefan Kress, Sigrun Merger, Wolfram Karges, Frank J. Wosch, Marcus Altmeier, Marianne Pavel, Reinhard W. Holl, DPV Initiative   +10 more
wiley   +1 more source

Immunopathogenesis and immunotherapy of Culicoides hypersensitivity in horses: an update

Veterinary Dermatology, Volume 32, Issue 6, Page 579-e156, December 2021., 2021
Culicoides hypersensitivity (CH) is a strongly pruritic dermatitis of horses, characterised histologically by mixed perivascular to diffuse cellular infiltrates of mononuclear cells and eosinophils, and caused by helper T cell (Th)2, immunoglobulin (Ig)E‐mediated reactions to antigens present in the saliva of biting Culicoides midges.
Eliane Marti, Ella N. Novotny, Iva Cvitas, Anja Ziegler, A. Douglas Wilson, Sigurbjörg Torsteinsdottir, Antonia Fettelschoss‐Gabriel, Sigridur Jonsdottir   +7 more
wiley   +1 more source

Updated insights into the molecular pathogenesis of canine atopic dermatitis

Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley   +1 more source

Immunotherapy using pullulan‐conjugated Der f 2 allergen in canine atopic dermatitis: An anti‐inflammatory agent‐sparing approach

Veterinary Dermatology, Volume 36, Issue 4, Page 443-452, August 2025.
Background – Allergen immunotherapy is used as aetiological treatment for canine atopic dermatitis (cAD). Objective – To assess the anti‐inflammatory agent‐sparing effect over 1 year of immunotherapy using pullulan‐conjugated recombinant Der f 2 (rDf2‐P). Conclusions and Clinical Relevance – Der f 2‐P immunotherapy can lead to a rapid reduction in anti‐
Masahiko Nagata, Jin Kozakai, Aya Yoshida, Kana Kameyama, Hiromi Oboso, Hisanori Muto, Shoji Ogino, Toshihiro Tsukui   +7 more
wiley   +1 more source

Evaluation of filaggrin 2 expression in dogs with atopic dermatitis before and after oclacitinib maleate administration

Veterinary Dermatology, Volume 36, Issue 4, Page 453-461, August 2025.
Background – Canine atopic dermatitis (cAD) is a chronic, inflammatory, multifactorial and pruritic disease. The presence of skin barrier impairment (e.g. filaggrin alterations), along with abnormal immune responses, can negatively impact cutaneous barrier function.
Wendie Roldan Villalobos, Tássia Ferreira, Fernanda Borek, Domenico Santoro, Lluis Ferrer, Marconi Farias   +5 more
wiley   +1 more source

Long‐lasting otic solution containing mometasone furoate can influence intradermal testing in dogs with healthy ears and otitis externa

Veterinary Dermatology, Volume 35, Issue 6, Page 736-744, December 2024.
Background – Topical therapy is preferred for otitis externa (OE) in dogs, and otic products commonly contain glucocorticoids that can be systemically absorbed and possibly interfere with diagnostic tests such as intradermal testing (IDT). Hypothesis/Objectives – To determine the effect of a long‐lasting otic solution containing mometasone furoate (MF)
Jennifer L. Clegg, Clarissa P. Souza, William E. Sander   +2 more
wiley   +1 more source

Longitudinal evaluation of the cutaneous and rectal microbiota of German shepherd dogs with perianal fistulas undergoing therapy with ciclosporin and ketoconazole

Veterinary Dermatology, Volume 35, Issue 4, Page 375-385, August 2024.
Background – Perianal fistulas are painful ulcers or sinus tracts that disproportionately affect German shepherd dogs and are proposed as a spontaneous animal model of fistulising Crohn's disease. Objectives – To characterise the rectal and cutaneous microbiota in German shepherd dogs with perianal fistulas and to investigate longitudinal shifts with ...
Christine L. Cain, Ellen White, Lindsey E. Citron, Qi Zheng, Daniel O. Morris, Elizabeth A. Grice, Charles W. Bradley II   +6 more
wiley   +1 more source

Update on the skin barrier, cutaneous microbiome and host defence peptides in canine atopic dermatitis

Veterinary Dermatology, Volume 35, Issue 1, Page 5-14, February 2024.
Background – Canine atopic dermatitis (AD) is a complex inflammatory skin disease associated with cutaneous microbiome, immunological and skin barrier alterations. This review summarises the current evidence on skin barrier defects and on cutaneous microbiome dysfunction in canine AD.
Domenico Santoro, Manolis Saridomichelakis, Melissa Eisenschenk, Chie Tamamoto‐Mochizuki, Patrick Hensel, Cherie Pucheu‐Haston, for the International Committee on Allergic Diseases of Animals (ICADA), Frane Banovic, Emmanuel Bensignor, Douglas DeBoer, Graig Griffin, Ralf Mueller, Tim Nuttall, Christine Prost   +13 more
wiley   +1 more source

Study of regulation of OVOL2 in colorectal cancer metastasis and invasion [PDF]

, 2016
OVOL2是进化上相当保守的一种转录因子，它与胚胎发育之间的关系已经被很多研究所报道，但是OVOL2与肿瘤的发生发展关系还知之甚少。本文主要从OVOL2是如何调控结直肠癌的转移与侵袭方面做了详细的研究。 首先我们从结直肠癌病人样本的组织芯片中发现肿瘤中OVOL2含量低的病人预后生存期更短。然后我们通过体外细胞增殖实验、裸鼠皮下成瘤实验、小鼠免疫组化实验、HE染色实验证实了OVOL2不能够抑制结直肠癌的增殖。于是我们猜测OVOL2可能是通过抑制结直肠癌转移和侵袭过程，延长患者的寿命 ...
孙广斌
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