Results 21 to 30 of about 14,256 (166)

Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells 2型糖尿病、细胞功能障碍和氧化还原信号的关系:人胰腺α‐和β‐细胞单细胞基因表达的meta分析

Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022
Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques, Emily Formato, Wenle Liang, Emily Leonard, Alicia R. Timme‐Laragy   +4 more
wiley   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, EarlyView.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

First report of indolent cutaneous T‐cell lymphoma in a fennec fox (Vulpes zerda)

Veterinary Dermatology, Volume 36, Issue 5, Page 707-711, October 2025.
A 10‐year‐old fennec fox (Vulpes zerda) was presented for multifocal regions of chronic alopecia and crusting. Cutaneous lymphocytosis was diagnosed through histopathological examination and immunohistochemical investigation. Clonal rearrangement of the T‐cell receptor gamma locus supports that lymphocytosis in this case is an indolent lymphoma ...
Kristen L. Shekelle, Alan R. Glassman, Kay A. Backues, Jennifer J. Kilburn, Desirae A. Foust‐Wheatcraft, Lauren Wood Stranahan   +5 more
wiley   +1 more source

Updated insights into the molecular pathogenesis of canine atopic dermatitis

Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley   +1 more source

Immunotherapy using pullulan‐conjugated Der f 2 allergen in canine atopic dermatitis: An anti‐inflammatory agent‐sparing approach

Veterinary Dermatology, Volume 36, Issue 4, Page 443-452, August 2025.
Background – Allergen immunotherapy is used as aetiological treatment for canine atopic dermatitis (cAD). Objective – To assess the anti‐inflammatory agent‐sparing effect over 1 year of immunotherapy using pullulan‐conjugated recombinant Der f 2 (rDf2‐P). Conclusions and Clinical Relevance – Der f 2‐P immunotherapy can lead to a rapid reduction in anti‐
Masahiko Nagata, Jin Kozakai, Aya Yoshida, Kana Kameyama, Hiromi Oboso, Hisanori Muto, Shoji Ogino, Toshihiro Tsukui   +7 more
wiley   +1 more source

Evaluation of filaggrin 2 expression in dogs with atopic dermatitis before and after oclacitinib maleate administration

Veterinary Dermatology, Volume 36, Issue 4, Page 453-461, August 2025.
Background – Canine atopic dermatitis (cAD) is a chronic, inflammatory, multifactorial and pruritic disease. The presence of skin barrier impairment (e.g. filaggrin alterations), along with abnormal immune responses, can negatively impact cutaneous barrier function.
Wendie Roldan Villalobos, Tássia Ferreira, Fernanda Borek, Domenico Santoro, Lluis Ferrer, Marconi Farias   +5 more
wiley   +1 more source

Long‐lasting otic solution containing mometasone furoate can influence intradermal testing in dogs with healthy ears and otitis externa

Veterinary Dermatology, Volume 35, Issue 6, Page 736-744, December 2024.
Background – Topical therapy is preferred for otitis externa (OE) in dogs, and otic products commonly contain glucocorticoids that can be systemically absorbed and possibly interfere with diagnostic tests such as intradermal testing (IDT). Hypothesis/Objectives – To determine the effect of a long‐lasting otic solution containing mometasone furoate (MF)
Jennifer L. Clegg, Clarissa P. Souza, William E. Sander   +2 more
wiley   +1 more source

Longitudinal evaluation of the cutaneous and rectal microbiota of German shepherd dogs with perianal fistulas undergoing therapy with ciclosporin and ketoconazole

Veterinary Dermatology, Volume 35, Issue 4, Page 375-385, August 2024.
Background – Perianal fistulas are painful ulcers or sinus tracts that disproportionately affect German shepherd dogs and are proposed as a spontaneous animal model of fistulising Crohn's disease. Objectives – To characterise the rectal and cutaneous microbiota in German shepherd dogs with perianal fistulas and to investigate longitudinal shifts with ...
Christine L. Cain, Ellen White, Lindsey E. Citron, Qi Zheng, Daniel O. Morris, Elizabeth A. Grice, Charles W. Bradley II   +6 more
wiley   +1 more source

Update on the skin barrier, cutaneous microbiome and host defence peptides in canine atopic dermatitis

Veterinary Dermatology, Volume 35, Issue 1, Page 5-14, February 2024.
Background – Canine atopic dermatitis (AD) is a complex inflammatory skin disease associated with cutaneous microbiome, immunological and skin barrier alterations. This review summarises the current evidence on skin barrier defects and on cutaneous microbiome dysfunction in canine AD.
Domenico Santoro, Manolis Saridomichelakis, Melissa Eisenschenk, Chie Tamamoto‐Mochizuki, Patrick Hensel, Cherie Pucheu‐Haston, for the International Committee on Allergic Diseases of Animals (ICADA), Frane Banovic, Emmanuel Bensignor, Douglas DeBoer, Graig Griffin, Ralf Mueller, Tim Nuttall, Christine Prost   +13 more
wiley   +1 more source

免疫组化在临床诊断中的作用 附视频

Zhongguo shiyan zhenduanxue, 1998
免疫组化在临床诊断中的作用纪小龙王淑琴李红芬免疫组织化学（ｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｓｔｒｙ，免疫组化）虽然已出现５０多年了，但广泛应用于病理常规诊断仅是近１０余年的事。根据组织和细胞内化学成分的不同而建立的特殊染色法，以在大体及组织学水平上找...
纪小龙, 王淑琴, 李红芬, 解放军总医院病理科   +3 more
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