Results 1 to 10 of about 21,935 (162)

The standardization of immunohistochemical detection and interpretation of CD30 expression in lymphomas [PDF]

open access: yes, 2023
CD30 can be expressed in a variety of lymphoma subtypes, among which classical Hodgkin lymphoma (CHL) and anaplastic large cell lymphoma (ALCL) are the most common ones.
CD-Positive Lymphoma Pathology Expert Group
core   +1 more source

兴奋性hiPSC源性类神经网络组织的构建

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2023
目的将人诱导多能干细胞源性神经前体细胞(hiPSC-NPCs)种植于去细胞视神经( DON)上,在体外构建一种具有突触传递功能的类神经网络组织,为神经组织损伤的修复提供一种有效途径。方法通过定向诱导和组织工程技术,联合应用hiPSCs和3D DON支架,构建一种新的类神经网络组织。定向诱导人诱导多能干细胞(hiPSCs)向人神经前体细胞( hNPCs)及神经元方向分化,使用免疫荧光染色鉴定细胞分化效率。制备3D DON支架,借助扫描电镜、Tunnel染色,鉴定支架形貌及细胞相容性。将诱导的hiPSC ...
苏琪淞   +7 more
doaj  

Detection of MTAP Protein and Gene Expression in Non-small Cell Lung Cancer [PDF]

open access: yes, 2011
Background and objective The abnormal expression of MTAP, a tumor suppressor gene, is found in a variety of tumor tissues. The aim of this study is to detect the expression of MTAP mRNA protein and the clinical significance for the therapy of non-small ...
Baoqing DING   +3 more
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Preparation and Characterization of Semaphorin3Fc Monoclonal Antibody and the Preliminary Application [PDF]

open access: yes, 2015
研究背景和目的 抑癌基因发生异常是癌症发生的机制之一。人类基因的很多区域发生改变时可导致细胞失控性生长。Sema3F作为肺癌19个候选抑癌基因之一,是Ⅲ型Semaphorin(即神经导向因子,最初作为Neuropilins的配体在神经系统中发挥排斥神经节轴突和调节神经系统发育的作用)家族的一个成员。目前有研究发现,与正常组织相比Sema3F蛋白在肿瘤细胞中的表达普遍存在下调的趋势,并在血管形成以及肿瘤增殖、凋亡、粘附和转移等中起着负向调节作用。此外,诸多体内或者体外实验已经证明 ...
李哲
core  

Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer [PDF]

open access: yes, 2011
Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer ...
Boshi WANG   +7 more
core  

Preparation and Characterization of Anti-Neuropilin2 Monoclonal Antibody and Its Preliminary Application [PDF]

open access: yes, 2016
研究背景和目的 Neuropilin2(NRP2)是一种多功能的新型受体,在神经系统发育、心血管系统、免疫系统及淋巴管生成等过程中发挥重要作用。最新研究表明,NRP2受体广泛表达于肿瘤细胞表面,与肿瘤血管形成以及肿瘤的发生发展、凋亡、粘附、侵袭和转移等生物学行为密切相关。多种肿瘤细胞均高表达NRP2,提示NRP2可能成为一种新型肿瘤标志物。NRP2通过多种机制调控肿瘤进展,NRP2-b1b2是其发挥作用的重要结构域,NRP2-b1b2结构域可以结合配体Ⅲ型Semaphorin和VEGF ...
杨芸
core  

免疫组化在临床诊断中的作用 附视频

open access: yesZhongguo shiyan zhenduanxue, 1998
免疫组化在临床诊断中的作用纪小龙王淑琴李红芬免疫组织化学(immunohistochemistry,免疫组化)虽然已出现50多年了,但广泛应用于病理常规诊断仅是近10余年的事。根据组织和细胞内化学成分的不同而建立的特殊染色法,以在大体及组织学水平上找...
纪小龙   +3 more
doaj  

Establishment and Application of Respiratory Syncytial Virus Animal Model [PDF]

open access: yes, 2016
人呼吸道合胞病毒(HumanRespiratorySyncytiaVirus,hRSV)是全球范围内引起下呼吸道感染主要病原体之一。其感染人群年龄分布广,新生儿与老年人是主要高危人群。据报道,几乎所有小于2周岁婴幼儿都有RSV感染经历,婴幼儿发病住院率高达2.5-4%。RSV引起大于65周岁的老年人感染率为3-4%,病死率约为2%。早产儿、先天性心脏病、先天性支气管及肺发育不良、免疫缺陷的婴幼儿RSV病死率率高达5%,造成严重的医疗负担。 RSV无安全、有效疫苗上市 ...
詹炉停
core  

Expression of CD63 in Lung Tissue of Guinea Pigs Dying of Anaphylactic Shock [PDF]

open access: yes, 2019
Objective To study the protein expression of cluster of differentiation 63 (CD63) in lung tissues of guinea pigs that died of anaphylactic shock and discuss the diagnostic value of CD63 for death from anaphylactic shock.
ZHANG Chu-nan, YU Hao, WANG Xiao-long,et al
core   +1 more source

免疫组化在临床诊断中的作用

open access: yesZhongguo shiyan zhenduanxue, 1998
免疫组化在临床诊断中的作用纪小龙王淑琴李红芬免疫组织化学(immunohistochemistry,免疫组化)虽然已出现50多年了,但广泛应用于病理常规诊断仅是近10余年的事。根据组织和细胞内化学成分的不同而建立的特殊染色法,以在大体及组织学水平上找...
纪小龙, 王淑琴, 李红芬
doaj  

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