Altered plasma cytokines in dogs with atopic dermatitis
Background – Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, Regulatory T (Treg) cells, eosinophils, mast cells and other immune components.
Hamutal Mazrier +3 more
wiley +1 more source
Narrative plots for regulatory, distributive, and redistributive policies
Abstract The Narrative Policy Framework (NPF) has ignited a remarkably active research community, one of its main contributions being distinct narrative elements—including settings, characters, and plots. Yet, while the plot constitutes a core element of narrativity, it has received less attention vis‐à‐vis other narrative components.
Johanna Kuhlmann, Sonja Blum
wiley +1 more source
Political Trust and Aspirations to Influence Social Media During a Crisis: A Longitudinal Study
ABSTRACT This study investigated how political trust shaped citizens' aspirations to influence others on social media during a COVID‐19 pandemic. Using four‐wave longitudinal survey data (2017–2021; N = 2172) collected from 543 citizens in Finland, we first analysed how political trust moderated the temporal development of individuals' aspirations to ...
Aki Koivula +2 more
wiley +1 more source
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source
New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu +8 more
wiley +1 more source
Partisan Emotions and Government Trust: Taiwan's COVID‐19 Experience
ABSTRACT This study investigates how political partisanship and emotional responses influenced Taiwanese public trust in government during COVID‐19. Drawing on crisis management and partisan motivated reasoning theories, we conducted a two‐phase survey (N = 2136) examining attitudes toward six significant pandemic events.
Chun‐Chieh Wang +2 more
wiley +1 more source
The Th cell subsets analysis of syphilis patients and mechanism of Treponema pallidum infection [PDF]
梅毒是由梅毒螺旋体引起的性传播疾病。梅毒螺旋体可侵入人体各个组织器官,引起各种临床表现。目前机体对梅毒螺旋体的免疫机制尚不清楚。本课题分别从体内和体外实验分析梅毒螺旋体引起的初始Th细胞分化,初步探讨梅毒螺旋体细胞免疫机制。我们分析32例梅毒患者外周血辅助性T细胞(Th)亚群含量变化;通过兔皮内接种模型,分析梅毒螺旋体感染后局部炎症反应中IFN-γ和IL-4mRNA的表达随时间变化情况。体内研究发现梅毒螺旋体感染后细胞免疫应答在人外周血和兔皮损中IFN-γ含量明显升高,Th1型细胞增多 ...
张巧
core
Effects of the Xitongxiao prescription on apoptosis and proliferation of chondrocytes in knee [PDF]
目的:探讨膝痛消方对促进软骨细胞增殖和抑制IL-1β诱导的软骨细胞凋亡的作用。方法:体外培养膝关节软骨细胞,用阿利新蓝染色方法检测软骨细胞蛋白多糖,用Ⅱ型胶原免疫荧光染色检测软骨细胞Ⅱ型胶原的表达,以鉴定软骨细胞;用MTS检测软骨细胞的增殖;用IL-1β诱导软骨细胞凋亡,AnnexinV/PI双染检测细胞凋亡。结果:膝关节剥离得到的细胞形态为多角形或梭形,阿利新蓝与Ⅱ型胶原免疫荧光染色均呈阳性,证明分离培养的细胞为软骨细胞 ...
刘志坤 +5 more
core +1 more source
Problems and Addressing Strategies in Community-based Management of Osteoarthritis: a Systematic Review [PDF]
Background Osteoarthritis is a common chronic disease in middle-aged and elderly people, which seriously affects their quality of life. Carrying out community-based management of osteoarthritis is conducive to the optimization of healthcare resource ...
Qian LIU, Hanzhi ZHANG, Mengsi QIU, Dehua YU
core +1 more source
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source

