Results 81 to 90 of about 143,222 (253)

Studies of the regulatory mechanism on myocardial related genes of Rbm24 [PDF]

open access: yes, 2015
实验目的 研究在心肌细胞分化和发育过程中,Rbm24蛋白发挥功能和产生的影响。寻找Rbm24结合的相关基因的不同水平的RNA,以及结合目的RNA后所发挥的功能,为降低Rbm24的表达导致扩张性心肌病等一系列心肌受损和功能紊乱相关疾病探究原因,寻找相关的信号通路,提供一定的实验及理论依据,为成功解决心脏疾病难题寻找重要的攻克点。 方法 通过Westernblot免疫印迹检测Rbm24和其他心肌相关蛋白在C2C12细胞分化中蛋白的表达情况 ...
杨康
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Geographic risks to functional groups of mammals and birds from habitat loss in Mexico

open access: yesConservation Biology, EarlyView.
Abstract There is a need to quantify the impact of habitat loss due to anthropogenic factors on different aspects of biodiversity, such as functional trait diversity represented by functional groups (FGs). We developed a metric to assess the weighted risk of loss of habitat for 33 FGs of mammals and 36 FGs of birds in Mexico based on potential ...
Fernando Mayani‐Parás   +4 more
wiley   +1 more source

Studies on the regulation of neural differentiation by multiple signals [PDF]

open access: yes, 2002
Thesis (Ph. D. in Agriculture)--University of Tsukuba, (A), no.
Hayashi Hisaki, 林 寿来
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An experimental approach to assess the combined effects of multiple stressors on a large vertebrate species

open access: yesConservation Biology, EarlyView.
Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta   +24 more
wiley   +1 more source

调节ALK5受体活化水平优化间充质干细胞的内皮分化及组织工程血管的应用

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2013
【目的】 目前干细胞分化内皮细胞(EC)用于血管治疗受限于分化率,既往研究提示转化生长因子β1(TGFβ1)参与内皮分化的调控,其作用因受体途径及分化阶段而不同?本实验即研究TGFβ1主要Ⅰ型受体ALK5活化水平与间充质干细胞(MSC)的内皮细胞分化效率间的关系及分化内皮细胞应用组织工程血管的研究?
doaj  

Constructed value of information with iterative scoring and parametric uncertainty to identify management‐relevant research priorities for a declining raptor species

open access: yesConservation Biology, EarlyView.
Abstract Constructed value of information (CVoI) is an expert elicitation decision‐analytic tool used to prioritize sources of uncertainty based on their potential to improve decision outcomes if resolved. Despite increased application of CVoI, the robustness of CVoI prioritization of sources of uncertainty relative to differences in expert elicitation
Kristin P. Davis   +7 more
wiley   +1 more source

NADPH氧化酶p22phox亚基基因His72Tyr与脂联素基因 启动子-11391G/A多态性的交互作用以及与大肠癌 及其分化程度的关系

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2016
摘 要: 【目的】 探讨烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶p22phox亚基基因His72Tyr与脂联素基因启动子-11391G/A多态性的交互作用以及与大肠癌及其分化程度的关系。 【方法】 选择我院2009年7月至2014年12月收治的大肠癌患者668例,分为高分化组、中分化组、低分化组、未分化组各162例,以162例健康体检者作为对照组,各组在年龄、性别、民族、籍贯和生活习惯方面无显著性差异,以上述各组患者的外周血白细胞为样本,利用聚合酶链反应-限制性片段长度多态性(PCR-RFLP ...
doaj  

Yin-Yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes [PDF]

open access: yes, 2005
Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no. 3804, 2005.3.25Offprint. Originally published in: Journal of Investigative Dermatology, v. 123, no. 6, pp.
許 雪珠
core  

Effects of landscape context on avian specialist response to increased surface temperature in protected areas

open access: yesConservation Biology, EarlyView.
Abstract Human development is a driver of global change and a major threat to biodiversity. Protected areas maintain and support biodiversity, but outside stressors, such as climate change and land use change, can negatively influence natural resources within protected areas.
Leah J. Rudge   +2 more
wiley   +1 more source

Identification of novel developmentally regulated genes in mouse central nervous system [PDF]

open access: yes, 1993
Thesis (Ph.D. in Science)--University of Tsukuba, (A), no.
Sazuka Takashi, 佐塚 隆志
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