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转移性去势抵抗性前列腺癌(mCRPC)患者因肿瘤异质性和耐药性预后不佳,抗体药物偶联物(ADC)治疗mCRPC部分临床试验中已展现出抗肿瘤活性及较好的安全性。在靶向前列腺特异性膜抗原(PSMA)的ADC中,相较于早期ADC如MLN2704、PSMA-ADC、MEDI3726,ARX517安全性更优,前列腺特异性抗原下降更显著。在靶向B7-H3的ADC中,MGC018和DB-1311也展现出抗肿瘤活性。靶向前列腺六跨膜上皮抗原(STEAP)1的DSTP3086S、靶向滋养层细胞表面抗原(TROP ...
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[High expression of MPP6 predicts poor patient prognosis and promotes malignant biological behaviors of hepatocellular carcinoma cells]. [PDF]
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[A Case of Refractory Pulmonary Enteric Adenocarcinoma with EGFR Sensitive Mutation]. [PDF]
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[Chinese guidelines for diagnosis and treatment of myelodysplastic neoplasms (2026)]. [PDF]
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[Targeting Regulatory T Cells to Remodel Peripheral Immune Tolerance: Research Advances and Future Directions]. [PDF]
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