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前列腺癌患者噬菌体抗体库的构建 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 2004
【目的】构建前列腺癌患者的噬菌体抗体库,为前列腺癌特异性的人源性抗体Fab片段的筛选及其应用奠定基础。【方法】由前列腺癌患者外周血分离得淋巴细胞,完整提取其总RNA,经RT-PCR及半套式扩增得到免疫球蛋白全部轻链和重链Fd段基因,然后经酶切、纯化、连接等步骤克隆进载体pComb3,并电转化大肠杆菌XL1-Blue,从而构建前列腺癌患者噬菌体抗体库。【结果】成功构建噬菌体抗体Fab片段库,其轻链及重链Fd段与载体DNA的重组率分别为87%、79%,库容为23.2×107,滴度为87×1012mL-1 ...
doaj   +1 more source

前列腺特异性膜抗原新型剪接变异体PSM-E 在外周血的定量表达

Zhongshan Daxue xuebao. Yixue kexue ban, 2009
【目的】 检测分析前列腺特异性膜抗原(PSMA)及其新型剪接变异体(PSM-E)在前列腺癌(PCA)及良性前列腺增生(BPH)患者外周血中的表达,探讨其意义65377; 【方法】 通过实时荧光定量PCR方法对PSM-E65380;PSMA在前列腺癌(53例)和前列腺增生(79例)两组患者外周血中定量表达,分析其差异65377; 【结果】 PSM-E相对表达量在PCA组(-8.22 ± 0.32)高于BPH组(-9.99 ± 0.41),P < 0.001;PSMA相对表达量在PCA组(-12.51 ...
doaj   +1 more source

PSA、PSAD、f/tPSA在早期前列腺癌诊断作用的研究

Zhongguo shiyan zhenduanxue, 2009
目的探讨前列腺特异性抗原（PSA）、PSA密度（PSAD）、游离PSA/总PSA比值（f/tPSA）在诊断早期前列腺癌（PCa）中的价值。方法对640例患者行前列腺穿刺活检,其中PSA0.15f ...
计国义, 王伟华, 赵微, 刘喜春, 赵雪俭   +4 more
doaj  

[Research progress on prostate-specific membrane antigen ligand positron emission tomography imaging of prostate cancer]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2022
Li Y, Liu B, Yuan Y, Qin W.
europepmc   +1 more source

[Recent advances in antibody-drug conjugates for metastatic castration-resistant prostate cancer]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Xu J, Ma Y, Hu P, Yao J, Chen H, Ma Q.
europepmc   +1 more source

[High expression of MYBL2 promotes progression and predicts a poor survival outcome of prostate cancer]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao, 2022
Yang M, Zhu X, Shen Y, He Q, Qin Y, Shao Y, Yuan L, Ye H.   +7 more
europepmc   +1 more source

Clinical application and progress of quantitative functional magnetic resonance imaging in prostate cancer. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021
Li M, Li W.
europepmc   +1 more source

[Design, Synthesis, and Efficacy Evaluation of a Novel BRD4/HDAC Dual-Target Small-Molecule Inhibitor in Prostate Cancer]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Feng S, Shao Y, Wu K, Yang W, Li X.
europepmc   +1 more source

[Multi-omics analysis of the relationship between oxidative stress-related gene and prostate cancer]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Ning J, Wang H, Luo S, Jing J, Wang J, Hou H, Liu M.   +6 more
europepmc   +1 more source

[EEFSEC knockdown inhibits proliferation, migration and invasion of prostate cancer cells in vitro]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao, 2021
Xu B, Hao J, Xie Q, Sa N, Wang S, DU X, Lu H, Gao P, Shi G, Dong X.   +9 more
europepmc   +1 more source