68Ga-PSMA-11 PET/CT双时相SUVmax与前列腺癌临床病理特征的相关性
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探讨 68Ga-PSMA-11 PET/CT双时相前列腺癌原发病灶最大标准摄取值（SUVmax）与初诊前列腺癌患者各项临床病理特征的相关性。方法回顾性收集我院2017年11月至2020年9月期间初次确诊为前列腺癌的患者，共19例，年龄（69.0±7.4）岁。所有患者均行68Ga-PSMA-11 PET/CT双时相检查，检查后两周内均行前列腺癌根治术。通过阈值自动分割法，计算出前列腺癌原发病灶在标准相SUVmax1、延迟相SUVmax2、双时相SUVmax差值SUVmax3。收集所有病人的临床 ...
李建芳 +7 more
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Correlation analysis of PSMA PET/CT-derived parameters and circulating tumor DNA features in patients with hormone-sensitive prostate cancer [PDF]
Background and purpose: Both prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) and circulating tumor DNA (ctDNA) sequencing outcomes serve as references for therapeutic decision-making in hormone ...
PAN Jian, YE Dingwei, ZHU Yao, WANG Beihe
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Expert consensus of 177Lu-labeled PSMA radioligand therapy for clinical practice of prostate cancer (2024 edition) [PDF]
177Lu-labeled prostate-specific membrane antigen radioligand therapy (177Lu-PSMA-RLT) is an innovative treatment approach that precisely delivers β radiation emitted by 177Lu to prostate cancer cells, causing radiation damage to the tumor cells’ DNA and ...
Cancer Nuclear Medicine Committee of China Anti-Cancer Association, Chinese Association of Nuclear Medicine Physicians
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The unique value and controversy of nuclear medicine molecular imaging in the evaluation of radioiodine-refractory differentiated thyroid cancer [PDF]
Nuclear medicine molecular imaging has the characteristics of non-invasiveness, high sensitivity, spatiotemporal dynamic visualization, qualitative and quantitative analysis, and by virtue of the advantages of fusion imaging technology, it combines the ...
WANG Renfei, LU Gaixia
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Progress and prospect on treatment for radioiodine-refractory thyroid cancer [PDF]
Most patients with differentiated thyroid cancer benefit from surgery, radioactive iodine-131 therapy and TSH suppression therapy, resulting in a favorable prognosis.
GENG Qianqian, YANG Aimin
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Advances in novel imaging agents targeting fibroblast activation proteins [PDF]
Based on the high target-to-background ratio（TBR），new imaging agents targeting fibroblast activation protein（FAP）have shown better imaging effects in a variety of tumors.
WANG Ning, SHI Yizhen
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鉴定AP-4是在非激素依赖型前列腺癌中上调L-plastin表达的转录因子 [PDF]
, 2006 【目的】鉴定AP-4是在非激素依赖型前列腺癌中调控L-plastin表达的转录因子，进一步阐明非激素依赖型前列腺癌的发病机制。【方法】在鉴定L-plastin启动子近3’端-216到1序列片段存在明显的转录活性的基础上，利用TFSEARCH软件分析该片段的序列，寻找可能调控L-plastin表达的非甾体激素类转录因子，并用凝胶滞后实验和超滞后实验证实结合于该片段的转录因子，利用PCR定点突变法构建删除该转录因子结合位点的重组子，并检测切除该片段序列后荧光素酶活性 ...
尹心宝 +7 more
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Innovations and Challenges in Molecular Probe-Based Precision Theranostics for Genitourinary System Tumors [PDF]
Genitourinary system tumors, as a major clinical challenge posing a serious threat to human health, urgently require breakthroughs in the construction of a precision diagnosis and treatment system.
Mingwei SUN, Pengyu GUO, Wanhai XU
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Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】构建 99m Tc标记前列腺癌特异性膜抗原（PSMA）适配体（A10-3.2），并探讨其在体内外的生物特点。【方 法】通过双功能螯合剂6-肼基烟酸琥珀酰亚胺酯盐酸盐（SHNH）对适配体A10-3.2进行 99m Tc标记（ 99m Tc- SHNH-A10-3.2）， 并检测其在体外的稳定性，被前列腺癌LNCaP细胞（PSMA+）摄取的特异性，在移植瘤小鼠体内SPECT/CT成像及生物分布 的特点。【结果】所构建 99m Tc-SHNH-A10-3.2的标记率和放化纯分别为（71 ...
吕殷婷, 曹素娥, 江淑琴
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