Results 21 to 30 of about 18,866 (201)
The pathophysiology of meibomian gland dysfunction related ocular surface diseases and the molecular mechanism [PDF]
, 2016 第一部分：睑板腺功能障碍诱导的小鼠干眼动物模型的建立 目的：睑板腺功能障碍（MGD）是引起蒸发过强型干眼最常见的病因，但是MGD引起的眼表面病变的病理生理过程目前还知之甚少。本研究的主要目的是建立蒸发过强型干眼的动物模型，并观察该类型干眼的眼表病理变化过程。 方法：用裂隙灯显微镜观察外异蛋白基因（EctodysplasinA，EDA)突变鼠（Tabby鼠）的眼表病变过程，用荧光素钠染色方法检测Tabby鼠的角膜上皮缺损状况，用酚红棉线检测小鼠的水性泪液分泌，对角膜和眼睑进行H&E染色和油红染色 ...
李三明
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Wildlife Letters, EarlyView.Asiatic black bears in Russia face conservation threats such as habitat destruction and fragmentation, which exacerbate food shortages caused by crop failures. This study explores an innovative approach to rehabilitating bears that abandon hibernation in mid‐winter due to extreme exhaustion by providing supplemental food near their den sites.
Sergey A. Kolchin +2 more
wiley +1 more source
Extraction and identification of urine derived stem cells and its effect on adriamycin induced nephropathy in mice [PDF]
, 2016 中文摘要 目的1、提取分离和培养尿源性干细胞(USCs urine-derivedstemcells)，并鉴定其相关生物学特性。 2、通过静脉注射盐酸阿霉素建立阿霉素肾病小鼠模型。 3、通过肾组织病理观察，检测生化，应用Westernblot技术观察USCs移植和胚胎干细胞治疗保护小鼠阿霉素肾病的效果，并对尿源性干细胞在阿霉素肾病小鼠中保护作用及相关机制进行探讨。 方法1、小鼠尿源性干细胞(USCs）的提取、分离、培养与鉴定:通过收集人尿液分离出尿源性干细胞，利用离心沉淀方法分离培养，体外纯化、传代 ...
孟昕
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Wildlife Letters, EarlyView.In this study we analyze the role of phylogeny, environment, and community structure on sociality. Using structural equation modeling (SEM) we aim to quantify the direct and indirect impacts of variables on behaviors including social grouping, reproduction, and space use among Carnivora species.
Jessica Ward +3 more
wiley +1 more source
MRI study of the effect of Sialic acid supplementation on piglets working memory [PDF]
, 2015 唾液酸（Sialicacid，Sia）是自然界中一系列酰基化形式神经氨酸衍生物的统称。唾液酸具有多种生物学功能，如：促进细胞的增殖、分化和参与识别；与病原微生物相互作用，参与机体免疫反应；促进神经系统发育，易化记忆形成，提高学习能力；且在大脑发育的关键时期，进行干预可以对大脑造成远期的不可逆的影响。许多动物实验表明唾液酸对大脑发育、学习和记忆能力产生重要影响，仔猪因大脑发育阶段和解剖结构与新生婴儿相似，适合用做研究婴儿脑区变化的动物模型。磁共振成像技术因其对软组织空间分辨率高 ...
吕春龙
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Wildlife Letters, EarlyView.Climate change drives shifts in suitable habitats for Eurasian lynx and its prey (hare, roe deer) in Mohe, Daxing'anling Mountains. Under RCP scenarios, moderate warming (RCP4.5) promotes substantial habitat expansion, while high‐emission conditions (RCP8.5) lead to strong expansion in the 2050s but slower gains and partial contraction by the 2070s ...
Binglian Liu +5 more
wiley +1 more source
Prenatal Exposure to Airborne Particulate Matter on the Development of Heart in Rat Fetus [PDF]
, 2015 大气颗粒物（ParticulateMatter，PM）是指悬浮在大气中的固体、液体颗粒物的总称。不同来源的颗粒物形成条件不同，其粒径分布、化学组成也不同。目前国际公认的对人类健康危害较大且研究较多的大气颗粒污染物是PM2.5（FineParticulateMatter）和PM10（InhalableParticulateMatter）[1]。越来越多的证据表明，PM严重威胁着人体的健康，更对孕妇及胎儿的发育产生不良影响，导致出生缺陷儿增多，使出生人口质量下降，增加死亡率。因此 ...
龙燕
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Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Plant phenology is crucial for understanding plant growth and climate feedback. It affects canopy structure, surface albedo, and carbon and water fluxes. While the influence of environmental factors on phenology is well‐documented, the role of plant intrinsic factors ...
Yunpeng Luo +8 more
wiley +1 more source
Metabolomic Study on the Advanced Pancreatic Cancer Model in Nude Mouse [PDF]
, 2016 胰腺癌是一种恶性程度极高的消化道类恶性肿瘤，早期无显著病征，病人在确诊时病情基本已处于中晚期，而研究显示，直径小于2cm和1cm的胰腺癌术后5年生存率分别可达30%-60%和超过75%，远高于中晚期术后5年生存率。 本文为课题“基于核磁共振的代谢组学技术发现胰腺癌的生物标志物及早期诊断应用”的一部分。整个课题目的在于通过系统分析动物和人类胰腺癌中晚期模型代谢通道的异同点，然后通过构建动物早期胰腺癌模型，并结合中晚期动物与人类胰腺癌代谢通路的共同点 ...
李志水
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Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Decomposition is the transformation of dead organic matter into its inorganic constituents. In most biomes, decomposition rates can be accurately predicted with simple mathematical models, but these models have long under‐predicted decomposition in globally extensive ...
Heather L. Throop +8 more
wiley +1 more source