Results 21 to 30 of about 13,210 (203)
The Role and Mechanism of RARα in the Development of Gastric Carcinoma [PDF]
, 2016 尽管胃癌的发病率在下降，但其死亡率仍位于全球第二位。由于缺乏有效的早期诊断方法，大多数胃癌病人在确诊时已到了晚期阶段。因此亟需寻找新的胃癌诊断与治疗的分子靶点。许多研究表明视黄酸受体在肿瘤的进程中起着重要的作用，然而，RARα与肿瘤的关系尚不清楚。本论文以胃癌为研究对象，阐明RARα在胃癌发生发展中的作用及其分子机制。 本论文主要通过Q-PCR、Westernblot、IHC/ICC等方法研究胃癌组织和细胞中RARα的表达情况及其临床意义。利用MTT、细胞集落形成、裸鼠皮下异种成瘤、流式细胞术 ...
任红岳
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Risk, Hazards &Crisis in Public Policy, Volume 16, Issue 3, September 2025.ABSTRACT When war refugees arrive in a host country, they may find themselves in a vulnerable condition and struggle to cope in a foreign setting. This article presents a systematic approach to identifying important communication‐related challenges that should be addressed by policymakers at the national level of the host country to reduce the ...
Kristi Aav +3 more
wiley +1 more source
Clinical Research on “Gui” Acupuncture Method for Chronic Non-specific Low Back Pain [PDF]
, 2016 目的：比较“龟刺”与常规针刺方法治疗慢性非特异性腰痛的疗效差异，为临床上治疗本病提供新的治疗思路和方法。 方法：本研究采用随机分组单盲对照法对所选病例进行前瞻性研究，受试者来源于厦门大学附属中山医院演武分院六楼针灸科门诊，收集符合纳入标准的60例慢性非特异性腰痛患者，随机分为治疗组与对照组，每组30例。治疗组按照周然宓教授所创“龟刺”法的选穴与操作标准，对照组按照石学敏主编《针灸学》中治疗腰痛的选穴与操作标准分别进行治疗。两组均以治疗10次为一个疗程，隔两天治疗1次，每周治疗2次，共治疗1个疗程 ...
张文龙
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Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 2, Page 200-209, August 2025.Abstract Objectives Neonates with critical congenital heart disease (CCHD) are at risk for adverse early brain development and long‐term neurodevelopmental sequelae. Insulin‐like growth factor‐1 (IGF‐1) and insulin‐like growth factor binding protein‐3 (IGFBP‐3) are essential contributors to brain growth and maturation.
M. Nijman +33 more
wiley +1 more source
The Relationship between Nano-quartz Oxidative Damage and the High Expression of Nuclear Factor NF-κB of Lung Cancer in Xuanwei, Yunnan [PDF]
, 2009 Background and objective To research the effect and practicalbility of lobectomy with bronchoplasty and reconstruction of pulmonary artery by minitrauma-technique for lung cancer.
Mengjiao QIAN, Yunchao HUANG
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Integrative Conservation, Volume 4, Issue 2, Page 143-153, June 2025.This study provided information on the abundance, population demography and activity pattern of an endangered species of Gekko badenii at the type locality of Ba Den Mountain, southern Vietnam. Local and international use and trade in Gekko badenii for food consumption and as pet were investigated and conservation recommendations highlighted.
Hai Ngoc Ngo +8 more
wiley +1 more source
Insulin enhances proliferation of hepatoma carcinoma cells by regulating the ubiquitination of glycolytic enzyme pyruvate kinase M2 [PDF]
, 2016 流行病学调查显示，胰岛素增加某些癌症的发病风险。胰岛素可作为一种生长因子促进细胞分裂；当体内有肿瘤细胞或突变细胞存在时，胰岛素可放大癌症的风险。但胰岛素对肿瘤细胞增殖调控的具体机制尚未明确。现有研究表明，丙酮酸激酶PKM2，在肿瘤中呈高表达，不仅是糖酵解限速酶，而且还具有转录因子活性，调控肿瘤细胞的增殖、迁移和侵袭过程，进而促进恶性肿瘤的发生发展。此外，核孤儿受体TR3能通过基因转录、蛋白质相互作用等参与细胞生长、自噬、增殖、凋亡、分化等生理过程，并且其功能发挥与亚细胞定位密切相关 ...
支蔷
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Risk, Hazards &Crisis in Public Policy, Volume 16, Issue 1, March 2025.Abstract At a time when disasters, pandemics, pollution, and other crises gain prominence, local governments bear a crucial responsibility for effective risk communication. Yet, there remains a gap in our understanding of how municipalities approach risk communication before a crisis occurs.
Hogne L. Sataøen +3 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2017 目的主要是为了评估高风险子痫前期妊娠期高血压患者的临床危险因素,另外还评估了子痫前期与妊娠期高血压的发病率以及复发率。方法采用队列研究获得相关数据进行分析,实验选取的孕妇包括至少含有以下一种子痫前期高风险因素:具有子痫前期的病史、临床上妊娠综合症病史、慢性高血压、糖尿病、多胎妊娠、肥胖或自身免疫性疾病。用多变量和单变量逻辑回归分析来评价高血压疾病发展过程中的临床特点和风险因素。结果 32.7%（36/110）的人患有高血压疾病,单变量分析得出子痫前期在怀孕之前是一个重要的高风险因素（OR 2.75,95%
朱君花, 雷侠
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CDK5 promotes HCC genesis and promotes cell migration by TPX2 [PDF]
, 2016 我国是世界上肝癌最高发的国家之一，由于其较高的发病率和致死率，严重威胁人民的健康，但目前大多数肝癌患者仍难以获得早期诊断及有效的治疗。细胞周期蛋白依赖性激酶5(cyclin-dependentkinase5，CDK5)是周期素依赖蛋白激酶家族的特殊成员，近年来发现其在肿瘤发生发展中起着关键的作用。CDK5通过与激活因子p35或p39结合后活化并磷酸化一系列下游分子，参与肿瘤细胞增殖、迁移、粘附、凋亡、细胞周期调控等。但CDK5对肝癌细胞功能的影响及其在肝癌中的调控机制还不清楚 ...
王付强
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