Results 91 to 100 of about 4,058 (195)
Functional analysis of osteopontin protein in the progression of ovarian cancer cells [PDF]
, 2005 OPN是一种重要的多功能细胞外基质蛋白。较早的研究发现OPN在骨组织细胞、巨噬细胞、平滑肌细胞、内皮细胞及上皮细胞等多种细胞表达，在介导细胞的趋化、聚积、血管生成与骨细胞的重建以及机体免疫调节等方面均有着重要作用。近几年还发现，OPN在许多肿瘤包括乳腺癌、前列腺癌、肝癌、结肠癌、食管癌、神经胶质瘤、肺癌以及胃癌等组织中的表达量较正常组织高，与肿瘤细胞的存活、侵袭转移及血管生成密切相关。我们利用免疫组织化学染色方法发现，OPN在卵巢癌组织中的表达高于正常卵巢组织，提示OPN与卵巢癌的发展密切相关。随后 ...
蔡秋凤
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Research advances in platinum resistance and its treatment in ovarian cancer [PDF]
Ovarian cancer is one of the most malignant gynecological tumors. Platinum-based chemotherapy is an important part of ovarian cancer treatment, with platinum resistance as a difficult problem in ovarian cancer treatment. Platinum resis-tance is a complex
LIU Yan, HUANG Li
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Zhongguo shiyan zhenduanxue, 2012 目的探讨巨噬细胞集落刺激因子（M-CSF）和肿瘤相关糖蛋白抗原72（TAG-72）在卵巢癌组织中的表达及意义。方法采用免疫组织化学法检测53例卵巢癌及15例正常卵巢组织中M-CSF、TAG-72的表达,并结合临床病理因素进行分析。结果 M-CSF和TAG-72在卵巢癌组织中的表达率（66%、26.4%）明显高于正常组织（33.3%、0）,差异均有显著性。同时,M-CSF及TAG-72在卵巢癌组织中的表达与手术病理分期、组织分级有关（χ2=5.428-8.256,P0.05）。结论 M-CSF及TAG ...
唐治蓉, 林雪梅, 赵涌
doaj
Study on the mechanisms and functions of lncRNAs in regulating carboplatin resistance in ovarian cancer cells [PDF]
Objective To screen for differentially expressed long non-coding RNAs (lncRNAs) in carboplatinresistant ovarian cancer (OC) based on expression profiling microarrays and conduct functional enrichment analysis to comprehensively understand the signaling ...
CHEN Cuilan +3 more
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Zhongguo shiyan zhenduanxue, 2013 卵巢癌是常见的妇科恶性肿瘤之一,也是死亡率最高的癌症之一,我国每年每10万人中就有5个被诊断为新发卵巢癌,被称为"隐形杀手"[1]。卵巢癌的早期症状不显著,超过70%-75%的卵巢癌患者确诊时已处于癌症晚期,5年生存率徘徊于30%-40%[2]。卵巢癌早期诊断并及时治疗,患者的存活率可提高到90%[3]。目前美国临床生化科学院（NACB）专家组建议将糖类抗原CA125作为卵巢癌鉴别诊断、疗效监测及判断复发上的唯一标志物,但其对疾病初期诊断的灵敏度和特异度较低。人附睾分泌蛋白4（human ...
王莹, 续薇
doaj
[Identification of key molecules in miRNA-mRNA regulatory network associated with high-grade serous ovarian cancer recurrence using bioinformatic analysis]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Zhang P, He M, Zeng Y, Cai X.
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BAG Family Gene and Its Relationship with Lung Adenocarcinoma Susceptibility [PDF]
, 2010 Background and objective BAG genes (Bcl-2-associated athanogene) belong to a recently discovered multifunctional anti-apoptosis gene family that regulate various physiological processes which include apoptosis, tumorigenesis, neural differentiation ...
Heng WU +9 more
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Zhongguo shiyan zhenduanxue, 2013 目的探讨肿瘤干细胞标记物Lgr5和CD133在卵巢癌中的表达和意义。方法利用免疫组织化学方法,观察33例卵巢浆液性乳头状腺癌、6例正常卵巢组织和6例卵巢浆液性囊腺瘤中Lgr5和CD133的表达情况。结果Lgr5在卵巢癌组织中阳性表达率为78.7%,与正常卵巢组织和浆液性囊腺瘤相比有显著性差异 ...
翟颖仙, 张丽红, 周莉, 王医术
doaj
The Expression and Biological Significance of PD-L1 on Lung Cancer Cell Lines [PDF]
, 2009 Background and objective Tumor-associated PD-L1 expression was recently shown to promote T-cell apoptosis and proposed as a potential mechanism of immune evasion by tumors. On the basis of the ability of tumor-associated PD-L1 to mediate activated T-cell
Cheng CHEN +6 more
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