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A quarter of a century since its discovery, circulating CA125 antigen is recommended for clinical use in the USA for ovarian cancer screening of high-risk women with ovaries, despite its limited sensitivity and specificity. Recent findings suggest that CA125 might also serve as a predictive marker for pre-invasive ovarian carcinoma. Methods to quantify
Nathalie Scholler, Nicole Urban
exaly +3 more sources
CA125 and Ovarian Cancer: A Comprehensive Review [PDF]
Ovarian cancer is the second most lethal gynecological malignancy. The tumour biomarker CA125 has been used as the primary ovarian cancer marker for the past four decades. The focus on diagnosing ovarian cancer in stages I and II using CA125 as a diagnostic biomarker has not improved patients’ survival.
Parsa Charkhchi +2 more
exaly +4 more sources
Exploring the Glycosylation of Serum CA125 [PDF]
Ovarian cancer is the most lethal gynaecologic cancer affecting women. The most widely used biomarker for ovarian cancer, CA125, lacks sensitivity and specificity. Here, we explored differences in glycosylation of CA125 between serum from patients with ovarian cancer and healthy controls.
Radka Saldova +2 more
exaly +3 more sources
Role of HE4 and ROMA Score in Diagnosis of Ovarian Cancer in Egyptian Women [PDF]
Background: Risk of ovarian malignancy algorithm (ROMA) combining human epididymis secretory protein 4 (HE4) and CA125 is a novel score, specific for epithelial ovarian cancer (EOC).
Nahla El-Attar +6 more
doaj +1 more source
Novel inflammatory markers and prognostic importance of platinum-sensitive ovarian carcinoma relapse [PDF]
Introduction/Objective. Ovarian carcinomas are the deadliest gynecological tumors. Despite advances in treatment options, survival rates are still not at the desired level.
Tay Fatih +2 more
doaj +1 more source
Correlation of Cytohistlogical Expression and Serum Level of Ca125 in Ovarian Neoplasm [PDF]
Context or Background: CA125 is a biomarker that has potential utility across the spectrum: risk assessment, early detection, diagnosis, prognosis, monitoring and therapy.
Chhanda Das +4 more
doaj +1 more source
Incidence of Endometriosis among Women Prepared for Laparoscopy in Unexplained Infertility and Chronic Pelvic Pain [PDF]
Background: Unexplained infertility continues to be a health challenge irrespective of revolution in medical care. Endometriosis could be associated with infertility.
Mohammed El-flahgy +2 more
doaj +1 more source
Objective To evaluate the value of PLT and its parameters combined with AFP, CA199, CA125 and CEA on the preoperative differential diagnosis of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).
ZHANG Haodong +3 more
doaj +1 more source
CA125 Immune Complexes in Ovarian Cancer Patients with Low CA125 Concentrations [PDF]
BACKGROUND About 20% of women with ovarian cancer have low concentrations of serum cancer antigen 125 (CA125), and this important tumor marker cannot be used to monitor their disease. The measured concentration for mucin 1 (MUC1), or CA15-3, another tumor marker, can be lowered in breast and ovarian cancer patients ...
Cramer, Daniel +7 more
openaire +4 more sources
CA125 Expression in Epithelioid Sarcoma [PDF]
There has been no report on useful immunohistological markers for epithelioid sarcoma (ES) so far. The purpose of this study is to evaluate the positivity and specificity of CA125 as a marker for the correct diagnosis of ES.This study was performed in 11 patients with ES (nine men and two women; distal type: 10 cases; proximal type: one case), 78 ...
Hiroshi, Kato +9 more
openaire +2 more sources

