Results 1 to 10 of about 28,557 (262)
HE4 as a Biomarker for Endometrial Cancer [PDF]
Cancers, 2021 There are currently no blood biomarkers in routine clinical use in endometrial carcinoma (EC). Human epididymis protein 4 (HE4) is a glycoprotein that is overexpressed in the serum of patients with EC, making it a good candidate for use as a diagnostic and/or prognostic biomarker.
Chloe E Barr, E J Crosbie
exaly +4 more sources
Overexpression of HE4/WFDC2 gene in mice leads to keratitis and corneal opacity [PDF]
Open Life SciencesHE4 is overexpressed in malignant lesions, and elevated serum HE4 levels have been applied as a biomarker for gynecologic cancers. While previous studies have demonstrated the HE4 activities in cancer biology, its role(s) in benign disease is unclear. In
Tuo Lingjin +6 more
doaj +2 more sources
HE4 (WFDC2) Promotes Tumor Growth in Endometrial Cancer Cell Lines [PDF]
International Journal of Molecular Sciences, 2013 HE4, also known as WFDC2, is a useful biomarker for ovarian cancer when either used alone or in combination with CA125. HE4 is also overexpressed in endometrial cancer (EC), but its function in cancer cells is not clear. In this study, we investigate the
Hai-Bin Chen +2 more
exaly +4 more sources
Human epididymis protein 4 (HE4) in benign and malignant diseases [PDF]
Clinical Chemistry and Laboratory Medicine, 2012 Background: Human epididymis protein 4 (HE4) is described as a useful new biomarker in ovarian cancer. As HE4 is neither tumor nor organ specific, we intensively investigated the occurrence of this protein in female and male patients with various benign ...
Linda Hertlein
exaly +3 more sources
HE4 in the differential diagnosis of ovarian masses [PDF]
Clinica Chimica Acta, 2015 Ovarian masses, a common finding among pre- and post-menopausal women, can be benign or malignant. Ovarian cancer is the leading cause of death from gynecologic malignancy among women living in industrialized countries.
ANASTASI, Emanuela +5 more
core +4 more sources
Expression and Diagnostic Value of HE4 in Pancreatic Adenocarcinoma [PDF]
International Journal of Molecular Sciences, 2015 Human epididymis protein 4 (HE4) is a recognized biomarker in ovarian and endometrial cancer and over-expressed in pancreatic adenocarcinoma. The diagnostic value of HE4 in pancreatic adenocarcinoma remains unknown. Here we elucidate mRNA, protein and serum level of HE4 in pancreatic adenocarcinoma.
Tianhe Huang +2 more
exaly +3 more sources
The NF-κB-HE4 axis: A novel regulator of HE4 secretion in ovarian cancer.
PLoS ONEOvarian cancer is the leading cause of death among gynecologic malignancies. Despite recent advancements in targeted therapies such as PARP inhibitors, recurrence is common and frequently resistant to existing therapies.
Kyukwang Kim +8 more
doaj +4 more sources
Evaluation of follow-up observation using human epididymis protein 4, a tumor marker, in patients with ovarian cancer [PDF]
Obstetrics & Gynecology Science, 2023 Objective We evaluated the usefulness of human epididymis protein 4 (HE4), a tumor marker, during and after treatment in patients with ovarian cancer (OC).
Masaya Uno +3 more
doaj +1 more source
Respiratory Research, 2022 Background Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by chronic inflammation and airway remodeling. Human epididymis protein 4 (HE4) plays a critical role in various inflammatory or fibrotic diseases.
Yuan Zhan +10 more
doaj +1 more source
Role of HE4 and ROMA Score in Diagnosis of Ovarian Cancer in Egyptian Women [PDF]
Middle East Journal of Cancer, 2021 Background: Risk of ovarian malignancy algorithm (ROMA) combining human epididymis secretory protein 4 (HE4) and CA125 is a novel score, specific for epithelial ovarian cancer (EOC).
Nahla El-Attar +6 more
doaj +1 more source