Results 11 to 20 of about 28,557 (262)

Elevation of serum human epididymis protein 4 (HE4) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) as predicting factors for the occurrence of acute kidney injury on chronic kidney disease: a single-center retrospective self-control study

Frontiers in Pharmacology, 2023
Objectives: To evaluate whether novel biomarkers of renal injury, serum HE4 and NT-proBNP could predict acute kidney injury (AKI) on chronic kidney disease (CKD) (A on C) and assess the specificity and efficiency of serum creatinine (SCr), HE4 and NT ...
Jinye Song, Ling Chen, Zheping Yuan, Xuezhong Gong   +3 more
doaj   +2 more sources

HE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Cardiac fibrosis plays a crucial role in the pathogenesis of dilated cardiomyopathy (DCM). HE4 (human epididymis protein 4) is a secretory protein expressed in activated fibroblasts that exacerbates tissue fibrosis.
Masahiro Yamamoto, Shinsuke Hanatani, Satoshi Araki, Yasuhiro Izumiya, Toshihiro Yamada, Nobuhiro Nakanishi, Toshifumi Ishida, Satoru Yamamura, Yuichi Kimura, Yuichiro Arima, Taishi Nakamura, Seiji Takashio, Eiichiro Yamamoto, Kenji Sakamoto, Koichi Kaikita, Kenichi Matsushita, Sachio Morimoto, Takaaki Ito, Kenichi Tsujita   +18 more
doaj   +2 more sources

Elevated level of serum human epididymis protein 4 (HE4) predicts disease severity and mortality in COVID-19 pneumonia

BMC Pulmonary Medicine, 2023
Background We retrospectively analyzed serum level of human epididymis protein 4 (HE4) as a pulmonary inflammatory biomarker in patients with COVID-19 pneumonia in association with disease severity and outcome.
Renáta Sütő, Marianna Pócsi, Zsolt Szabó, Zsolt Fejes, Gergely Ivády, György Kerekes, Miklós Fagyas, Attila Nagy, Zoltán Szentkereszty, János Kappelmayer, Béla Nagy   +10 more
doaj   +2 more sources

HE4 and CA-125 kinetics to predict outcome in patients with recurrent epithelial ovarian carcinoma: the META4 clinical trial

Frontiers in Oncology
HE4 and CA-125 are used for epithelial ovarian cancer (EOC) screening, diagnosis, and follow-up. Our objective was to study HE4 and CA-125 kinetics in patients treated for recurrent EOC.
Michel Fabbro, Pierre-Jean Lamy, Pierre-Jean Lamy, Célia Touraine, Anne Floquet, Isabelle Ray-Coquard, Caroline Mollevi   +6 more
doaj   +2 more sources

MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension

Cardiovascular Therapeutics, 2022
Background. Pulmonary arterial hypertension (PAH) usually causes right ventricular dysfunction, which is closely related to cardiac fibrosis. But cardiac fibrosis mechanism remains unclear.
Yi Tang, Xiaowei Huo, Junyu Liu, Yijin Tang, Min Zhang, Wenlin Xie, Zhaofen Zheng, Jin He, Jiayan Lian   +8 more
doaj   +1 more source

Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis

RMD Open, 2022
Objectives IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder with heterogeneous manifestations. This study aimed to investigate the utility of human epididymis protein 4 (HE4) as a potential clinical biomarker of fibrosis in
Wen Zhang, Yongzhe Li, Yuan Huang, Songxin Yan, Yu Peng, Hui Lu, Ziyan Wu, Shengwei Mo, Xianlong Chen, Xiaomeng Li   +9 more
doaj   +1 more source

Serum Human Epididymis Protein 4 as a Novel Biomarker in Identifying Patients With Interstitial Lung Disease in Rheumatoid Arthritis

Frontiers in Medicine, 2021
Objective: Human epididymis protein 4 (HE4) have been implicated in the pulmonary involvements. We aimed to investigate the clinical utility of HE4 in clinical stratification in patients with rheumatoid arthritis (RA).Methods: This study included a ...
Liu Liang, Liu Liang, Jiali Chen, Chun Di, Minghua Zhan, Huizhang Bao, Changsheng Xia, Chunhong Fan, Yudong Liu   +8 more
doaj   +1 more source

A Dual Biomarker TK1 Protein and CA125 or HE4-Based Algorithm as a Better Diagnostic Tool than ROMA Index in Early Detection of Ovarian Cancer

Cancers, 2023
Simple Summary Ovarian cancer is one of the most difficult tumors to detect and manage. Usually, it is diagnosed in late stage of the disease which is associated with poor prognosis. Therefore, it is important to detect this cancer in the early stages to
Diana Cviič, K. Jagarlamudi, L. Meglič, E. Škof, A. Zore, David Lukanović, S. Eriksson, J. Osredkar   +7 more
semanticscholar   +1 more source

Performance of IOTA Simple Rules Risks, ADNEX Model, Subjective Assessment Compared to CA125 and HE4 with ROMA Algorithm in Discriminating between Benign, Borderline and Stage I Malignant Adnexal Lesions

Diagnostics, 2023
BACKGROUND: Borderline ovarian tumors (BOTs) and early clinical stage malignant adnexal masses can make sonographic diagnosis challenging, while the clinical utility of tumor markers, e.g., CA125 and HE4, or the ROMA algorithm, remains controversial in ...
A. Czekierdowski, N. Stachowicz, A. Smoleń, Tomasz Łoziński, Paweł Guzik, T. Kluz   +5 more
semanticscholar   +1 more source

The Establishment of an HE4‐CLIA Method and the Combined Analysis of HE4 and CA125 in Ovarian Cancer [PDF]

Journal of Clinical Laboratory Analysis, 2016
BackgroundThe human epididymal secretory protein 4 (HE4) is a novel, verified biomarker for the early diagnosis of ovarian cancer.MethodsMagnetic beads were coated with capture antibodies and were used with acridinium ester labeled detection antibodies in a sandwich‐type immunoassay.
Qiong, Zhang, Cong-Rong, Wang, Juan-Ping, Yu, Qiang, Ma, Wei-Wen, Xu   +4 more
openaire   +2 more sources