Results 41 to 50 of about 37,370 (230)

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Diagnostic Value of Preoperative CA125, LDH and HE4 for Leiomyosarcoma of the Female Reproductive System

, 2021
Fenfen Zhang,1 Yao Liu,2 Quan Quan,1 Yu Meng,1 Xiaoling Mu1 1Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Obstetrics and Gynecology, Chengdu First ...
Zhang F, Liu Y, Mu X, Quan Q, Meng Y
core  

Exploratory Analysis of CA125-MGL and –STn Glycoforms in the Differential Diagnostics of Pelvic Masses [PDF]

, 2022
BackgroundThe cancer antigen 125 (CA125) immunoassay (IA) does not distinguish epithelial ovarian cancer (EOC) from benign disease with the sensitivity needed in clinical practice. In recent studies, glycoforms of CA125 have shown potential as biomarkers
Seija Grènman, Taija Heinosalo, Anne Lone Rolfsen, Kim Pettersson, Liina Salminen, Matti Poutanen, Kaisa Huhtinen, Urpo Lamminmäki, Antti Perheentupa, Kamlesh Gidwani, Anne Dørum, Olli Carpén, Nimrah Nadeem, Sakari Hietanen, Teemu D Laajala, Nils Bolstad, Johanna Hynninen   +16 more
core   +1 more source

Experience and Lessons Learned in the Treatment of Transforming Small Cell Neuroendocrine Carcinoma of the Prostate: A Case Report and Literature Review

Case Reports in Oncology
Introduction: Small cell neuroendocrine carcinoma of the prostate (SCNECP) is a rare and highly malignant tumor that commonly transforms into conventional prostate adenocarcinoma (CPAC).
Binbin Song, Yan Luo, Qing Li, Hong Pan, Dong Li   +4 more
doaj   +1 more source

A real-world comparison of the clinical and economic utility of OVA1 and CA125 in assessing ovarian tumor malignancy risk

Journal of Comparative Effectiveness Research, 2023
Aim: This largest-of-its-kind study evaluated the clinical utility of CA125 and OVA1, commonly used as ovarian tumor markers for assessing the risk of malignancy.
Gerard P Reilly, David A Gregory, Dennis J Scotti, Samuel Lederman, Wade A Neiman, Steven Sussman, Lisa M Bean, Mercedes M Ekono   +7 more
doaj   +1 more source

A Binding Domain on Mesothelin for CA125/MUC16 [PDF]

Journal of Biological Chemistry, 2009
Ovarian cancer and malignant mesothelioma frequently express both mesothelin and CA125 (also known as MUC16) at high levels on the cell surface. The interaction between mesothelin and CA125 may facilitate the implantation and peritoneal spread of tumors by cell adhesion, whereas the detailed nature of this interaction is still unknown.
Osamu, Kaneko, Lucy, Gong, Jingli, Zhang, Johanna K, Hansen, Raffit, Hassan, Byungkook, Lee, Mitchell, Ho   +6 more
openaire   +2 more sources

Clinically Informed Intelligent Classification of Ovarian Cancer Cells by Label‐Free Holographic Imaging Flow Cytometry

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Quantitative phase maps of single cells recorded in flow cytometry modality feed a hierarchical architecture of machine learning models for the label‐free identification of subtypes of ovarian cancer. The employment of a priori clinical information improves the classification performance, thus emulating the clinical application of liquid biopsy during ...
Daniele Pirone, Beatrice Cavina, Daniele Gaetano Sirico, Martina Mugnano, Vittorio Bianco, Lisa Miccio, Anna Myriam Perrone, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac, Pasquale Memmolo, Pietro Ferraro   +11 more
wiley   +1 more source

Analysis of serum level of HE4 and CA125 considering selected risk factors among patients with endometrioid endometrial cancer

, 2017
The aim of the study : To assess the difference of serum level of HE4 and CA125 among patients with endometrioid endometrial cancer, considering the presence or absence of selected risk factors.
Malgorzata Kania, Krzysztof Cendrowski, Anna Slomka, Robert Piorkowski, Wlodzimierz Sawicki, Nabil Abdalla   +5 more
core   +1 more source

Co-expression of mesothelin and CA125/MUC16 is a prognostic factor for breast cancer, especially in luminal-type breast cancer patients

Biomarker Research, 2021
The expression of mesothelin correlates with a poor prognosis in patients with breast cancer. Since mesothelin plays a role in cancer metastasis in association with CA125, we herein examined the expression of mesothelin and CA125, and the ...
Takahiro Einama, Yoji Yamagishi, Yasuhiro Takihata, Takafumi Suzuki, Tamio Yamasaki, Yuichi Hirose, Kazuki Kobayashi, Naoto Yonamine, Ibuki Fujinuma, Takazumi Tsunenari, Makiko Koga, Yusuke Ishibashi, Ken Nagata, Takehiro Shiraishi, Akiko Nakazawa, Toshimitsu Iwasaki, Eiji Shinto, Kimi Kato, Kimiya Sato, Hideki Ueno, Yoji Kishi, Hitoshi Tsuda   +21 more
doaj   +1 more source

Effects of GnRH Agonist and Dienogest in Combination on HE4 and CA125 Levels in Patients with Adenomyosis and Adenomyoma: A Prospective Cohort Study

Clinical and Experimental Obstetrics & Gynecology, 2023
Background: The traditional pathology of adenomyosis (AM) suggests that this is a common benign uterine disease. Hysterectomy is the gold standard of care and is viewed as a decisive treatment for AM; however, more conservative treatment approaches are ...
DongGe Wang, LiMei Ji, CenLin Jia, MingJun Shao   +3 more
doaj   +1 more source