Results 11 to 20 of about 1,201 (112)
International Journal of Cancer, EarlyView.Primary central nervous system diffuse large B‐cell lymphoma (PCNS‐DLBCL) lacks an optimal first‐line induction strategy, particularly for older patients and those ineligible for intensive consolidation. In this retrospective cohort of 36 newly diagnosed patients, the rituximab + methotrexate + thiotepa (RMT) regimen as first‐line induction achieved ...
Haotian Wang +10 more
wiley +1 more source
Wildlife Letters, EarlyView.In the winter of 2021/2022, a winter track survey revealed 43–46 tigers (without cubs) in 5.4 thousand km2 of suitable habitats in the Southwest Primorsky Province of Russia. In the same period, a network of camera traps registered 54 adult/subadult tigers here.
Yury Darman, Dina Matiukhina
wiley +1 more source
Cancer Science, EarlyView.KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui +4 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2021 目的探讨吉林省鼠伤寒沙门菌多位点可变数目串联重复序列(MLVA)分型的流行特征,为食源性腹泻感染的预防控制提供依据。方法根据国际Pulse Net公布的鼠伤寒沙门菌MLVA分型方法对吉林省2014-2016年间食源性感染腹泻病例分离的71株鼠伤寒沙门菌进行流行特征分析。结果 71株菌中46株分离自男性,25株分离自女性;以0-8岁儿童居多(59.2%);夏季为流行高峰期。聚类分析显示,71株菌被分为5大基因群(A-E群)37个基因型,B基因群(78.9%)为吉林省近年主要的流行菌群。吉林省6个地区(长春、
王岙 +6 more
doaj
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Through Mendelian randomization analysis of the quantitative trait locus data, we identified that four drug targets, namely CASP1, FST, IL10RA, and SUCNR1, have significant genetic associations with the risk of focal epilepsy. This analysis provides preliminary genetic evidence for the causal mechanism by which these targets are involved in the onset ...
Huaiyu Sun +4 more
wiley +1 more source
源荷储多类型灵活性资源协调的高比例可再生能源电源规划 [PDF]
全球能源互联网, 2019 未来高比例可再生能源电力系统愿景下，具有波动性和不确定性的风/光等可再生能源作为主要能源供应者，给电力系统带来了巨大的灵活性需求，考虑单一类型灵活性资源提供调节能力的规划模型和以净负荷包络线为基础的电源规划方法将不再适用。引入灵活性指标量化评估源荷储多类型灵活性资源的调节潜力并作为优化决策变量纳入到规划模型中，从而建立以全周期投资成本最小化为目标的高比例可再生能源电源规划模型。通过电源投资决策、生产模拟和灵活性评估3个流程模块，实现单位投资改善灵活性指标最优的电源规划方案求解。最后 ...
徐唐海, 鲁宗相, 乔颖, 安军
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eFood, Volume 7, Issue 3, June 2026.Purified ginseng adventitious root polysaccharides (GARP) improve insulin resistance by enhancing glucose and lipid metabolism and reducing oxidative stress. These beneficial effects are mediated, at least in part, through activation of the Nrf2/Keap1 signaling pathway in cellular and animal models.
Tian‐fu Yang +5 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Schisandra chinensis peptides (SCP) exhibited potent in vitro antioxidant activity and repaired UVB‐induced oxidative damage in HaCaT cells, while demonstrating excellent stability and biosafety. SCP also activated the Keap1/Nrf2 pathway, with IFSPWL identified as the key bioactive peptide that forms the most stable Keap1 complex via integrated ...
Shuo Zheng +7 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.Proposed signaling pathway by which TY modulates NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis. ABSTRACT This research focuses on exploring the modulation of pyroptosis and its underlying mechanisms via the “Tianyu” formulation (TY), a traditional Chinese medicine, in human rheumatoid arthritis fibroblast‐like synovial cells (RA‐HFLS) and a collagen ...
Yueya Zhu +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing +14 more
wiley +1 more source