摘 要: 【目的】 探讨IL-17基因缺失对小鼠重症哮喘肺部炎性反应的影响?【方法】 通过鼻腔给予纯化尘螨提取物对野生型(WT)和IL-17基因敲除(IL-17KO)小鼠建立重症哮喘模型,造模结束后,收集支气管肺泡盥洗液(BALF)及肺组织?通过免疫组化染色观察IL-17在WT小鼠肺组织中的表达情况?检测BALF中细胞数量?分型(包括巨噬细胞?中性粒细胞?淋巴细胞?嗜酸性粒细胞和上皮细胞)?通过ELISA测定BALF中IL-17?IL-4?IL-5?IL-13?TNF-?琢?IFN-γ ...
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[Effect of the number of sensitizing allergens on the efficacy of subcutaneous immunotherapy and quality of life in children with asthma]. [PDF]
Xu MY +6 more
europepmc +1 more source
[Review of and Reflections on the Current Status of Childhood Asthma Diagnosis and Treatment in China]. [PDF]
Hong JG.
europepmc +1 more source
[Research advances in non-pharmacological interventions in pediatric asthma]. [PDF]
Wang WR, Peng W, Zheng XR.
europepmc +1 more source
[VDAC1 participates in house dust mite-induced asthmatic airway inflammation in mice by inducing ferroptosis of airway epithelial cells]. [PDF]
Huang Y, Lin L, Huang H, Dong H.
europepmc +1 more source
雷公藤甲素对哮喘小鼠气道重塑及 转化生长因子-β1表达的影响
【目的】 探讨雷公藤甲素对支气管哮喘(简称哮喘)小鼠气道重塑的影响。【方法】 40只雌性SPF级BABL/c小鼠,随机数字表法分为4组,每组10只、A组为生理盐水对照组;B组为卵蛋白(OVA)哮喘组;C组为雷公藤甲素治疗组;D组为地塞米松治疗组。在末次激发24 h后所有小鼠取左肺组织行苏木精-伊红(HE)染色,过碘酸-雪夫(PAS)染色,Masson三色染色以及抗转化生长因子β1(TGF-β1)抗体免疫组化染色。测定支气管管壁厚度(WAt/Pbm),支气管平滑肌厚度(WAm/Pbm)?取右肺组织行RT ...
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[Pathological roles of lipid metabolism disorders in asthma and related intervention strategies]. [PDF]
Chen Q, Niu C, Guo Z, Xiang Y.
europepmc +1 more source
Association between ADRB2 regulatory region polymorphisms and susceptibility to childhood asthma. [PDF]
Cai MX +5 more
europepmc +1 more source
Type 2 inflammation accelerates CD4<sup>+</sup> T-cell senescence in asthma. [PDF]
Liu H, Li Z, Sun Y, Aili A, Chang C.
europepmc +1 more source
Efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children: a real-world study. [PDF]
Wang HM +25 more
europepmc +1 more source

