Results 41 to 50 of about 822 (100)
Detection of complex hemoglobinopathies: recommendations on screening and DNA testing
Thalassemia Reports, 2011 The following recommendations should be taken into account during the evaluation and elucidation of the complex hemoglobinopathies: a) in complex hemoglobinopathies performing DNA studies on all family members might be essential; b) complex gene-gene ...
E. Baysal
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红细胞参数的运算公式对缺铁性贫血与β-地中海贫血鉴别诊断价值探讨
Zhongguo shiyan zhenduanxue, 2012 目的探讨红细胞参数的运算公式对缺铁性贫血与β-地中海贫血鉴别诊断的实用价值。方法使用全自动血细胞分析仪对160例缺铁性贫血和172例β-地中海贫血患者的红细胞相关参数进行检测,以文献报道的5个红细胞参数的运算公式作为缺铁性贫血与β-地中海贫血的鉴别指标,分析它们的灵敏度、特异度、假阳性率、假阴性率、阳性预测值、阴性预测值、约登指数、阳性似然比、阴性似然比、对应的ROC曲线以及曲线下面积。结果在诊断IDA时,MI、S&BI、SI、和EI灵敏度在72.5%-81.88%,但特异度较低,在22.09%-26 ...
陶义丰 +4 more
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Fertility assessment in thalassemic men
Thalassemia Reports, 2017 Male infertility in β-thalassemia patients is typically considered to be the consequence of iron deposition in the endocrine glands. Adult male patients with β-thalassemia, on regular blood transfusions, are prone to developing acquired hypogonadism. The
Shahla Ansari +5 more
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红细胞参数及计算公式对缺铁性贫血与地中海贫血鉴别诊断效能比较
Zhongguo shiyan zhenduanxue, 2018 目的比较8种红细胞参数及计算公式对缺铁性贫血与地中海贫血鉴别诊断的实际效能。方法用全自动血球仪对本院产检接收的110例缺铁性贫血和211例地中海贫血患者的红细胞参数进行检测,以文献报导的8种红细胞参数及计算公式(依次标记为F1-F8)为鉴别指标,分析它们的灵敏度、特异度、阳性预测值、阴性预测值、约登指数、阳性似然比、阴性似然比、对应的ROC曲线以及曲线下面积(AUC)。结果发现公式F7、F8和F5的鉴别效能明显高于其余5个公式,3个公式的AUC分别为0.978、0.953and 0.925 ...
贺海林 +6 more
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Two rare hemoglobin variants with α thalassemia in Eastern Indian population
Thalassemia Reports, 2013 The current work focuses on two rare hemoglobin (Hb) variants - Hb Grange-Blanche and Hb Hofu - found for the first time in association with α-thalassemia in Eastern India. The unusual case of Hb Grange-Blanche and FS 41/42(-CTTT) mutations in cis throws
Dipanwita Das +6 more
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[Risk factors for hemorrhagic cystitis in children with β-thalassemia major after allogeneic hematopoietic stem cell transplantation]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2023 Chen XL +6 more
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Zhongguo shiyan zhenduanxue目的 探讨平均红细胞体积(MCV)、平均红细胞血红蛋白(MCH)、平均红细胞血红蛋白浓度(MCHC)和血红蛋白A2(HbA2)在α-地中海贫血(简称α-地贫)筛查中的价值。方法 选取2019年1月至2020年12月在桂林医学院第二附属医院进行地中海贫血基因检测，确诊为α-地贫患者223例，以及地中海贫血基因诊断阴性的健康对照者689例为研究对象，分析其血常规检查和血红蛋白电泳检测结果，并运用受试者工作曲线(ROC曲线)评估各指标对α-地中海贫血的筛查性能。结果 223例α-地贫患者中，标准型α ...
谢思燕, 莫丽军, 蒋惟, 韦传东
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Genotypes of thalassemia in children: an analysis of 30 417 cases. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2021 Li DM, He S.
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β-地中海贫血症患者血清铁调素hepcidin、GDF15表达及与预后的关系
Zhongguo shiyan zhenduanxue, 2022 目的 观察β-地中海贫血症患者血清铁调素hepcidin、生长分化因子15(GDF15)表达水平变化，并分析其与预后的关系。方法 选取汉川市人民医院106例β-地中海贫血症患者（研究组），并选取同期50例体检健康者纳入对照组，检测其血清hepcidin、GDF15水平，随访2年，记录患者生存情况，采用Logistic回归模型分析其预后影响因素。结果 轻型组、重型组与中间型组血清hepcidin水平明显低于对照组（P0.05）;GDF15水平为：重型组>中间型组>轻型组>对照组（P0.05）；死亡组Hb ...
李秀, 谢玉文, 陈会荣
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Thalassemia Reports, 2014 Thalassemia major is a genetic disorder and blood transfusion is critical for survival in these patients. Over the course of the past three decades, hyper transfusion therapy in these patients has shown has dramatically extended life expectancy and ...
Kritanjali Singh +2 more
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