基因芯片 - Open Access .click

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Zhongshan Daxue xuebao. Yixue kexue ban, 2009
【目的】建立并优化利用微阵列-比较基因组杂交技术检测单细胞非整倍体的实验方案65377; 【方法】纤维母细胞系GM02732(47, XY, +18)和GM00343[46, XY, 4(del) (qter > p14)]被用于实验65377;阳性对照组为上述细胞系的基因组DNA(gDNA)(A组与B组,n = 6);实验组为单细胞模板的多重置换扩增(MDA)产物(C组与D组,n = 10);阴性对照组为空白对照的MDA产物(E组,n = 6)65377;以上样本与10 k 2 ...
doaj

[Analysis and clinical characteristics of SLC26A4 gene mutations in 72 cases of large vestibular aqueduct syndrome]. [PDF]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Liu Y +13 more
europepmc +1 more source

[Prediction of hearing change in children with enlarged vestibular aqueduct with different genotypes by linear mixed-effects model]. [PDF]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Deng L +7 more
europepmc +1 more source

基于表观基因组学数据分析阿尔茨海默病中差异基因表达的研究

Zhongguo shiyan zhenduanxue
目的利用表观基因组学数据探究阿尔茨海默病(Alzheimer’s disease, AD)中差异基因的表达。方法从GEO(gene expression omnibus, GEO)数据库中下载mRNA表达微阵列数据集GSE1297和GSE4757,以及DNA甲基化450 K芯片数据集GSE125895,利用Bioconductor包进行数据预处理，使用R中的limma包筛选出差异表达基因(differentially expressed genes, DEGs)和差异甲基化基因 ...
于倩 +6 more
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[circ_EPHB4 synergizes with YTHDF3 to promote glioma progression via m6A-dependent stabilization of Wnt3]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Jin C, Liu J, Liu B, Fei X, Liao Y.
europepmc +1 more source

[Fufang Changtai Decoction Inhibites Colorectal Cancer Through Ferroptosis: Investigation of the Underlying Mechanism]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Gu J +6 more
europepmc +1 more source

三个石骨症致病基因内的新突变及其基因型－表型

Zhongshan Daxue xuebao. Yixue kexue ban, 2016
【目的】对２例恶性石骨症以及１例ＡＤＯⅡ型石骨症患者的致病基因ＴＣＩＲＧ１及ＣＬＣＮ７进行致病性突变的研究，以扩展突变谱，为开发针对突变类型的产前诊断性芯片的设计提供数据支持。【方法】收集３名石骨症患者及其父母的外周血，提取ＤＮＡ，ＰＣＲ扩增ＴＣＩＲＧ１及ＣＬＣＮ７基因的所有外显子及剪切位点序列，对ＰＣＲ产物进行Ｓａｎｇｅｒ测序并进行生物信息学分析，同时对新发现的突变在５０名正常对照中进行测序，以排除良性多态性。【结果】在患者１的ＴＣＩＲＧ１基因第４外显子发现缺失突变ｃ．２４２ｄｅｌＣ（ｐ ...
doaj

[Effect of dephosphorylation of tumor metastasis suppressor gene LASS2 on vacuolar ATPase activity and invasiveness of prostate cancer]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Liu Y +8 more
europepmc +1 more source

[Correlations of immune cell infiltration characteristics with clinicopathological parameters in patients with clear cell renal cell carcinoma]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhao H +6 more
europepmc +1 more source

[Public Database-based Study to Explore the Expression and Role of DDB1  in Lung Adenocarcinoma]. [PDF]

Zhongguo Fei Ai Za Zhi
Zou X, He Z, Zhang Y, Hu Y, Wang X, Wu Z. +5 more
europepmc +1 more source

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