Results 71 to 80 of about 32,478 (167)
3.0T高分辨磁共振血管壁成像评估颈动脉斑块性质对脑梗死复发的预测价值
Zhongguo shiyan zhenduanxue目的分析3.0T高分辨磁共振血管壁成像（HR-MRI） 评估颈动脉斑块性质对脑梗死复发的预测价值。方法选取2019年1月至2024年8月在邯郸市中心医院诊治且行HR-MRI检查的脑梗死患者50例为研究对象，根据既往有无梗死病史将其分为复发组和初发组，分析比较两组患者的基本临床资料、脂质坏死核心、颈动脉斑块负荷参数、斑块稳定性、纤维帽破裂及斑块内出血发生情况。结果复发组不稳定性斑块检出率高于初发组（χ2=4.751，P=0.029）；复发组管壁标准化指数(NWI)水平高于初发组（P<0.05 ...
岳志领 +6 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2012 【目的】 利用microRNA芯片技术分析比较两组不同复发倾向肝癌患者的miRNA表达谱,并在更大样品的基础上进行实验验证?【方法】收集10例原发性肝癌组织标本根据术后复发情况分2组:早期复发组与非早期复发组,运用microRNA芯片技术筛选出差异表达显著的microRNAs?结合文献报道,选择mir-144?mir-502-3p作为其他82例肝癌组织标本qReal-time PCR验证的检测指标?并利用生物信息学方法预测其靶基因?【结果】本研究共筛选获得7个差异表达的microRNAs ...
区应亮, 侯宝华, 简志祥
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Study on the effects of down-regulating Annexin A3 expression on biological behaviors of lung adenocarcinoma and its molecular mechanism [PDF]
, 2015 肺癌是我国第一大癌症，其发病率和死亡率均居恶性肿瘤之首，严重危害人类健康。肺癌按组织学类型可分为鳞癌、腺癌、小细胞癌和大细胞癌。近年来，肺腺癌（lungadenocarcinoma，AdC）的发病率呈逐步上升趋势，且患者死亡率高、预后极差。癌细胞易转移是肺腺癌患者预后差的主要原因，因此，探寻肺腺癌转移的分子机制及其新的治疗靶标，对于提高肺腺癌患者预后意义重大。我们前期研究中，采用定量蛋白质组学技术鉴定出AnnexinA3（Anxa3）为一个新的肺腺癌转移相关分子 ...
刘青青
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Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT The inherent brittleness of hardmetals stems from the rigid covalent bond in the ceramic matrix and the sharp ceramic/metal interface, which restricts the nucleation and motion of dislocations. In this study, a novel strategy is proposed to activate significant dislocation behaviors in the WC matrix by employing a non‐equiatomic CoNiFeCr ...
Cheng Qian +9 more
wiley +1 more source
Design, Synthesis and Evaluation of Novel Benzamide Derivatives as Antitumor Agents [PDF]
, 2016 肿瘤作为威胁人类身体健康的一种重大疾病，其治疗一直被全世界所重视。随着研究的不断深入，研究发现肿瘤是复杂的疾病，其生长和存活不仅仅依赖于一种受体或一种信号通路。单一靶点药物不能阻断肿瘤的所有信号通路，而联合用药又有可能影响药物的吸收和代谢，甚至造成更加严重的药物不良反应。因此，多靶点抗肿瘤药物随之诞生，它能够同时作用于某一肿瘤的多个靶点从而产生多种药理活性。相较于单一靶点而言，具有避免药物相互影响、作用全面、不良反应少等优势。 本文以课题组前期研究中发现的化合物HJ-47和YSM-14为先导化合物 ...
黄志宁
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World Water Policy, Volume 12, Issue 2, May 2026.ABSTRACT Water governance has emerged as a critical analytical framework for addressing the complexity of socioecological water systems in contexts of increasing climate vulnerability and anthropogenic pressure. This study presents a systematic review and bibliometric analysis of 50 scientific articles indexed on water governance published between 2018
Roger Pichis‐García +1 more
wiley +1 more source
Functional Ecology, Volume 40, Issue 5, Page 1415-1427, May 2026.Read the free Plain Language Summary for this article on the Journal blog. Abstract Wildfires are disrupting and regenerating forces in nature that affect all ecosystem components. However, the impact of wildfires on soil multitrophic biodiversity and the resulting consequences for ecosystem multifunctionality (EMF) remain poorly understood.
Juan Zhou +6 more
wiley +1 more source
人乳头状瘤病毒感染与鼻内翻性乳头状瘤发病、复发及恶变关系的研究
Zhongguo shiyan zhenduanxue, 2019 目的探究人乳头状瘤病毒(HPV)与鼻内翻性乳头状瘤(SNIP)发病、复发及恶变间的关系。方法收集2004.09-2017.09于首都医科大学附属北京同仁医院入院接受手术治疗患者的石蜡标本(156例),按术后病理诊断分为正常黏膜组织组(简称正常组,共33例)及SNIP组(123例),随访截至2017.11.30(平均随访时间62.15月),按随访结果分为治愈组(至随访结束暂未见复发或恶变,57例)、复发组(至随访结束出现一次及以上复发但暂未出现恶变,30例)、恶变组(至随访结束已出现明确恶变、原位癌变或中-
王阳, 吴迪, 娄鸿飞, 王成硕
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Jellyfish blooms restructure plankton dynamics and trophic linkages in coastal waters
Functional Ecology, Volume 40, Issue 5, Page 1443-1460, May 2026.Read the free Plain Language Summary for this article on the Journal blog. Abstract Jellyfish blooms are increasing globally in frequency and intensity, introducing complex ecological interactions, yet the mechanisms by which they alter ecosystem structure remain poorly characterized due to a lack of sustained field observations.
Pengpeng Wang +4 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 1992 1980～1990年,作者收治原发性肝癌660例,手术切除124例(18.8％)。术后肝内复发者32例(肝内复发率25.8％),2 年以内复发者占93.8％。93.7％合并肝硬化,15.5％并发门脉高压症。复发肝癌中4例(3.2％,4/124)行再切除,术后生存平均26.8月;22例行B超引导肝癌复发灶无水酒精注射术,术后8例死亡,平均生存8.5月;10例行肝动脉栓塞化疗或肝动脉结扎及插管化疗,术后生存平均16.8月,对照组仅4.5月。复发癌再次外科治疗以再切除术为首选(术后生存26.8～42.6月 ...
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