Results 21 to 30 of about 14,785 (141)

Glomerular cell cross talk in diabetic kidney diseases 糖尿病肾病中肾小球细胞间的相互作用

Journal of Diabetes, Volume 14, Issue 8, Page 514-523, August 2022., 2022
Highlights Glomerular cell cross talk is essential for maintaining the glomerular filtration barrier. In‐depth exploration of intraglomerular signaling pathway changes during diabetic kidney disease may help discover new therapeutic targets. Abstract Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus.
Ruixue Dong, Youhua Xu
wiley   +1 more source

Health utilities in Chinese patients with coronary heart disease and impaired glucose tolerance (ACE): A longitudinal analysis of a randomized, double‐blind, placebo‐controlled trial 中国冠心病合并糖耐量异常患者的健康相关生活质量:一项随机、双盲、安慰剂对照试验的纵向分析

Journal of Diabetes, Volume 14, Issue 7, Page 455-464, July 2022., 2022
Highlights The Acarbose Cardiovascular Evaluation (ACE) trial assessed the effects of acarbose in patients with coronary heart disease (CHD) and impaired glucose tolerance (IGT) in China. Acarbose treatment did not impact on health‐related quality of life in ACE trial participants with CHD and IGT. Myocardial infarction (MI), stroke, heart failure, and
José Leal, Frauke Becker, Lee‐Ling Lim, Rury R. Holman, Alastair M. Gray   +4 more
wiley   +1 more source

Lipid variability and risk of microvascular complications in Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: A post hoc analysis 控制糖尿病心血管风险的行动(ACCORD)试验中的血脂变异性和微血管并发症风险:一项事后分析

Journal of Diabetes, Volume 14, Issue 6, Page 365-376, June 2022., 2022
HighlightsAssociation of lipid variability with diabetic microvascular complications. Abstract Background Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of lipid variability on the risk of diabetic microvascular outcomes among type 2 diabetes mellitus patients.
Daniel Nyarko Hukportie, Fu‐Rong Li, Rui Zhou, Jia‐Zhen Zheng, Xiao‐Xiang Wu, Meng‐Chen Zou, Xian‐Bo Wu   +6 more
wiley   +1 more source

Time‐limited diets and the gut microbiota in cardiometabolic disease 限时进食及肠道菌群在心脏代谢性疾病中的作用

Journal of Diabetes, Volume 14, Issue 6, Page 377-393, June 2022., 2022
Highlights Time‐specific diet is a novel nutritional approach to prevent and treat cardiometabolic disease. Feeding‐fasting cycles shape gut microbial composition and metabolite production. These alterations may play a causative role in driving the cardiometabolic benefits of intermittent fasting.
Karina Ratiner, Hagit Shapiro, Kim Goldenberg, Eran Elinav   +3 more
wiley   +1 more source

Placental biomarker and fetoplacental Doppler abnormalities are strongly associated with placental pathology in pregnancies with small‐for‐gestational‐age fetus: prospective study

Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 6, Page 749-760, June 2025.
ABSTRACT Objective Placental dysfunction can result in small‐for‐gestational age (SGA) or fetal growth restriction (FGR). The aim of this prospective cohort study was to assess the association of the cerebroplacental ratio (CPR) and other more conventional fetoplacental Doppler indices, circulating placental growth factor (PlGF) levels and soluble fms ...
J. Hong, K. Crawford, E. Cavanagh, V. Clifton, F. da Silva Costa, A. V. Perkins, S. Kumar   +6 more
wiley   +1 more source

糖尿病酮症酸中毒合并心衰及糖尿病大疱病1例

Zhongguo shiyan zhenduanxue, 2021
糖尿病大疱病是一种少见的糖尿病并发症,发病率为0.16%-0.5%[1-2],发病时皮肤水疱突然形成,可自行消退,一般在2-5周愈合,不遗留疤痕或萎缩,常有反复发作病史,多合并有糖尿病周围神经病变[3-4]、大血管病变[5]、微血管病和血糖控制不佳[6],以及钙,镁代谢紊乱等。目前糖尿病酮症酸中毒合并心衰是否能够诱发糖尿病大疱病,或是该状态下快速补液能否诱发糖尿病大疱病尚不明确。本文报道1例糖尿病酮症酸中毒(DKA)合并心衰及糖尿病大疱病的患者,探讨该状态下诱发糖尿病大疱病的可能因素。
乔月, 李阳阳, 程妍, 王丽娟, 杨茂光, 刘琳, 蔡寒青, 张秀娟   +7 more
doaj  

The effect of pentosan polysulfate on diabetic nephropathy renal tubular epithelial cells injury through regulating p38 MAPK signaling pathway [PDF]

, 2016
目的：观察戊糖多硫酸钠是否通过调控P38MAPK干预糖尿病肾病肾小管上皮细胞的损伤。方法：利用不同浓度（10mmol/L～50mmol/L）葡萄糖刺激肾小管上皮细胞（HK-2）48h，应用CCK-8比色法检测肾小管上皮细胞增殖的改变。利用不同时间段（0h～48h）葡萄糖刺激细胞，用Westernblot法检测P38MAPK蛋白的表达水平。分为正常对照组（control组）、高糖组（HG组，葡萄糖30mmol/L)、戊糖多硫酸钠（PPS）组（PPS200µg/mL)、高糖＋戊糖多硫酸钠组（HG＋
张天英
core  

A blinded randomised split‐body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis

Veterinary Dermatology, Volume 36, Issue 3, Page 291-301, June 2025.
Background – Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics. Hypothesis/Objectives – This split‐body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE ...
A. Lange, U. Mayer, E. Bensignor, L. Cornegliani, D. Ferreira, I. Matricoti, M. Mosca, L. Ordeix, D. Pin, F. Scarampella, E. Videmont, A. Yu, O. Fantini   +12 more
wiley   +1 more source

The Protective Effect and Mechanism of Puerarin on Vascular Endothelial Cells Injury [PDF]

, 2013
葛根素是从传统中药葛根中提取的一种异黄酮，具有抗炎、抗动脉粥样硬化、抗氧化、降血糖、降血压、降血脂等多种药理活性，广泛用于糖尿病及心血管病的预防和治疗。表观遗传学相关的组蛋白甲基化作为基因表达的调控者，直接参与了糖尿病血管内皮细胞炎性损伤的过程，成为糖尿病血管病发生的一个基本的机制和防治的新途径。 本文采用高糖体外培养人血管内皮细胞模拟糖尿病时血管内皮细胞所处的高血糖环境，加入葛根素进行干预，利用RT-PCR技术检测细胞中与血管功能和血管炎症相关基因的表达 ...
韩鹏
core  

Progress of olfactory changes in metabolic diseases and the mechanisms [PDF]

Metabolic disorders, characterized by a complex pathogenesis, are experiencing a rising prevalence globally and a trend toward younger populations, making them a significant public health concern.
LI Huating, WU Qian
core   +1 more source