Establishment and Preliminary Applications of the Rotavirus Sucking Mouse Model
, 2014 A组轮状病毒是导致婴幼儿腹泻的主要病原体，每年全球因轮状病毒导致的死亡病例高达60万。目前轮状病毒感染没有特效的治疗药物，现有的疫苗在不同的地区保护效果差距较大，价格昂贵且存在发生潜在感染的安全隐患，因此更加安全可靠、高效廉价疫苗的研发就成为当务之急。有效的动物模型是疫苗研发过程十分重要的环节和保障，也是研究病毒感染进程和致病机理的主要手段。本研究的目标在于建立稳定的、可有效感染发病的轮状病毒乳鼠动物模型，并控制可能影响评价的各种因素，分析优化各项评价指标的使用；初步探索将模型用于保护性的评价 ...
林海军
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Zhongshan Daxue xuebao. Yixue kexue ban, 1991 建立人轮状病毒(HRV)电转印免疫印迹技术(electrotransfering immunoblotting,ETIB)分析了3个不同血清型别的HRV抗原与同型及异型豚鼠抗血清的ETIB反应。在此基础上,以HRV Wa,Yo,Hochi株为抗原,用ETIB法检测46例急性腹泻患儿,17例正常婴幼儿及30例脐带血血清中抗HRV各种多肽的抗体及其出现的动态。结果提示,不同血清型HRV每株的内外衣壳蛋白之间,分别具有共同的某些抗原决定簇。根据HRV ETIB反射扫描结果分析,HRV毒株之间其Vp3 ...
doaj
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